ES8306388A1 - Procedimiento para preparar antibioticos y antitumorigenos de la familia de bleomicina-fleomicina, designados ll-b01208 y ll-b01208 y las sales de adicion de acido farmaceuticamente aceptables de los mismos. - Google Patents

Procedimiento para preparar antibioticos y antitumorigenos de la familia de bleomicina-fleomicina, designados ll-b01208 y ll-b01208 y las sales de adicion de acido farmaceuticamente aceptables de los mismos.

Info

Publication number
ES8306388A1
ES8306388A1 ES509802A ES509802A ES8306388A1 ES 8306388 A1 ES8306388 A1 ES 8306388A1 ES 509802 A ES509802 A ES 509802A ES 509802 A ES509802 A ES 509802A ES 8306388 A1 ES8306388 A1 ES 8306388A1
Authority
ES
Spain
Prior art keywords
alpha
beta
antibiotic
stramineum
mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509802A
Other languages
English (en)
Other versions
ES509802A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES509802A0 publication Critical patent/ES509802A0/es
Publication of ES8306388A1 publication Critical patent/ES8306388A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/625—Streptoverticillium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic

Abstract

PROCEDIMIENTO PARA PREPARAR ANTIBIOTICOS Y ANTITUMORIGENOS DE LA FAMILA DE BLEOMICINA/FLEOMICINA. CONSISTE EN FERMENTAR AEROBICAMENTE EL ORGANISMO STREPTOVENTICILLIUM STRAMINEUM O MUTANTES DEL MISMO EN UN MEDIO LIQUIDO QUE CONTIENE FUENTES ASIMILABLES DE CARBONO, NITROGENO Y SALES INORGANICAS, HASTA QUE EL MEDIO QUEDE CON ACTIVIDAD ANTIBIOTICA Y DEL QUE SE RECUPERA EL ANTIBIOTICO. EL CULTIVO ES CAPAZ DE PRODUCIR LOS ANTIBIOTICOS LL-B01208~C Y LL-301208~J EN CANTIDADES RECUPERABLES POR FERMENTACION DE UN MEDIO NUTRITIVO ACUOSO QUE CONTIENE FUENTES ASIMILABLES DE CARBONO, NITROGENO Y SUSTANCIAS INORGANICAS. LOS COMPUESTOS TIENEN LA ESTRUCTURA DE FORMA GENERAL (I).
ES509802A 1981-02-23 1982-02-22 Procedimiento para preparar antibioticos y antitumorigenos de la familia de bleomicina-fleomicina, designados ll-b01208 y ll-b01208 y las sales de adicion de acido farmaceuticamente aceptables de los mismos. Expired ES8306388A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23719781A 1981-02-23 1981-02-23

Publications (2)

Publication Number Publication Date
ES509802A0 ES509802A0 (es) 1983-06-01
ES8306388A1 true ES8306388A1 (es) 1983-06-01

Family

ID=22892721

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509802A Expired ES8306388A1 (es) 1981-02-23 1982-02-22 Procedimiento para preparar antibioticos y antitumorigenos de la familia de bleomicina-fleomicina, designados ll-b01208 y ll-b01208 y las sales de adicion de acido farmaceuticamente aceptables de los mismos.

Country Status (10)

Country Link
US (1) US4552867A (es)
EP (1) EP0058838A1 (es)
JP (1) JPS57155993A (es)
AR (1) AR227962A1 (es)
AU (1) AU8065682A (es)
DK (1) DK76482A (es)
ES (1) ES8306388A1 (es)
FI (1) FI820575L (es)
GR (1) GR75176B (es)
ZA (1) ZA821146B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970198A (en) * 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5037651A (en) * 1987-01-30 1991-08-06 American Cyanamid Company Dihydro derivatives of LL-E33288 antibiotics
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
US5053394A (en) * 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1038242A (en) * 1963-03-05 1966-08-10 Zaidan Hojin Biseibutsu Bleomycin and processes for preparation thereof
FR2087990A1 (en) * 1970-05-05 1972-01-07 American Cyanamid Co Antifungal antibiotic bk 217
US3922262A (en) * 1971-04-28 1975-11-25 Nippon Kayaku Kk N-Substituted derivatives of bleomycins
JPS5739751B2 (es) * 1972-03-03 1982-08-23
US4246400A (en) * 1979-07-13 1981-01-20 Bristol-Myers Company Tallysomycin compounds
JPS5625197A (en) * 1979-07-19 1981-03-10 Microbial Chem Res Found Cleomycin and its preparation

Also Published As

Publication number Publication date
AR227962A1 (es) 1982-12-30
AU8065682A (en) 1982-09-02
EP0058838A1 (en) 1982-09-01
ES509802A0 (es) 1983-06-01
JPS57155993A (en) 1982-09-27
GR75176B (es) 1984-07-13
ZA821146B (en) 1983-01-26
FI820575L (fi) 1982-08-24
US4552867A (en) 1985-11-12
DK76482A (da) 1982-08-24

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