ES8105728A1 - Procedimiento para la preparacion de derivados dibenzo(b,f) tiepin-3-carboxilico. - Google Patents

Procedimiento para la preparacion de derivados dibenzo(b,f) tiepin-3-carboxilico.

Info

Publication number
ES8105728A1
ES8105728A1 ES491886A ES491886A ES8105728A1 ES 8105728 A1 ES8105728 A1 ES 8105728A1 ES 491886 A ES491886 A ES 491886A ES 491886 A ES491886 A ES 491886A ES 8105728 A1 ES8105728 A1 ES 8105728A1
Authority
ES
Spain
Prior art keywords
thiepin
carboxylic acid
pharmaceutical compositions
preparation
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491886A
Other languages
English (en)
Other versions
ES491886A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8105728A1 publication Critical patent/ES8105728A1/es
Publication of ES491886A0 publication Critical patent/ES491886A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C205/52—Nitro-acetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DIBENZO (B, F)-TIEPIN-3-CARBOXILICO DE FORMULA (I), DONDE Z ES TIO, SULFINILO O SULFONILO Y X ES FLUOR O HIDROXI. CONSISTE EN SOMETER A HIDROLISIS ACIDA O BASICA UN COMPUESTO DE FORMULA (II), DONDE W ES -CN, -COOR3, -COOR1R2, -COR4 O COOM, SIENDO R1, R2 Y R3 DIFERENTES COMPUESTOS R4 HALURO O ANHIDRIDO Y M ION METALICO O ION AMONIO. CUANDO Z ES SULFINILO, EL PRODUCTO OBTENIDO DE LA ETAPA ANTERIOR SE RESUELVE CROMATOGRAFIANDO UNA MEZCLA DE DIASTEREOMEROS DE UNA AMIDA PROCEDENTE DE UNA AMINA OPTICAMENTE ACTIVA Y RECUPERANDO EL COMPUESTO DESEADO POR HIDROLISIS DE LA CORRESPONDIENTE AMINA. LOS DERIVADOS OBTENIDOS TIENEN APLICACION EN EL TRATAMIENTO DE ASMA ALERGICO. *FORMULA*
ES491886A 1979-06-01 1980-05-27 Procedimiento para la preparacion de derivados dibenzo(b,f) tiepin-3-carboxilico. Granted ES491886A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4444479A 1979-06-01 1979-06-01
US4444579A 1979-06-01 1979-06-01

Publications (2)

Publication Number Publication Date
ES8105728A1 true ES8105728A1 (es) 1981-06-16
ES491886A0 ES491886A0 (es) 1981-06-16

Family

ID=26721570

Family Applications (4)

Application Number Title Priority Date Filing Date
ES491886A Granted ES491886A0 (es) 1979-06-01 1980-05-27 Procedimiento para la preparacion de derivados dibenzo(b,f) tiepin-3-carboxilico.
ES499341A Expired ES8201999A1 (es) 1979-06-01 1981-02-11 Un procedimiento para la preparacion del 5-oxido del acido 8-fluordibenzo (b,f) tiepin-3-carboxilico
ES499339A Expired ES8201997A1 (es) 1979-06-01 1981-02-11 Un procedimiento para la preparacion del 5-oxido del acido 8-fluordibenzo (b,f) tiepin-3-carboxilico
ES499340A Expired ES8201998A1 (es) 1979-06-01 1981-02-11 Un procedimiento para la preparacion del 5-oxido del acido 8-fluordibenzo (b,f) tiepin-3-carboxilico

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES499341A Expired ES8201999A1 (es) 1979-06-01 1981-02-11 Un procedimiento para la preparacion del 5-oxido del acido 8-fluordibenzo (b,f) tiepin-3-carboxilico
ES499339A Expired ES8201997A1 (es) 1979-06-01 1981-02-11 Un procedimiento para la preparacion del 5-oxido del acido 8-fluordibenzo (b,f) tiepin-3-carboxilico
ES499340A Expired ES8201998A1 (es) 1979-06-01 1981-02-11 Un procedimiento para la preparacion del 5-oxido del acido 8-fluordibenzo (b,f) tiepin-3-carboxilico

Country Status (13)

Country Link
EP (1) EP0023078B1 (es)
AU (1) AU534849B2 (es)
DD (1) DD152559A5 (es)
DE (1) DE3067522D1 (es)
DK (1) DK233180A (es)
ES (4) ES491886A0 (es)
FI (1) FI801638A (es)
GR (1) GR68550B (es)
IE (1) IE49833B1 (es)
NO (1) NO801625L (es)
NZ (1) NZ193765A (es)
PL (1) PL121395B1 (es)
PT (1) PT71280B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO811187L (no) * 1980-11-24 1982-05-25 Merck & Co Inc Fremgangsmaate ved fremstilling av 7-fluor-dibenzo-(b,f)-thiepinderivater
US4472586A (en) * 1982-09-30 1984-09-18 Merck Frosst Canada, Inc. 6H-Dibenz[b,e][1,4]oxathiepin derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT68303A (en) * 1977-07-26 1978-08-01 Merck & Co Inc Process for the preparation of dibenzo/b,f/thiepin
IT7850376A0 (it) * 1977-07-26 1978-07-19 Merck & Co Inc Composizioni di dibenzo(b.f)tiepina e procedimento per la loro preparazione

Also Published As

Publication number Publication date
EP0023078B1 (en) 1984-04-18
PT71280B (en) 1981-09-17
DE3067522D1 (en) 1984-05-24
ES499340A0 (es) 1982-01-16
EP0023078A1 (en) 1981-01-28
AU534849B2 (en) 1984-02-16
ES499341A0 (es) 1982-01-16
GR68550B (es) 1982-01-18
IE49833B1 (en) 1985-12-25
DD152559A5 (de) 1981-12-02
ES499339A0 (es) 1982-01-16
ES8201999A1 (es) 1982-01-16
PT71280A (en) 1980-06-01
DK233180A (da) 1980-12-02
AU5891580A (en) 1980-12-04
NZ193765A (en) 1984-07-31
IE801139L (en) 1980-12-01
ES8201998A1 (es) 1982-01-16
NO801625L (no) 1980-12-02
FI801638A (fi) 1980-12-02
PL121395B1 (en) 1982-04-30
ES8201997A1 (es) 1982-01-16
ES491886A0 (es) 1981-06-16
PL224662A1 (es) 1981-02-13

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