ES8306140A1 - Un procedimiento para la preparacion de derivados de la 3-sustituido-7-fluor-dibenzo-b,f, tiepina. - Google Patents
Un procedimiento para la preparacion de derivados de la 3-sustituido-7-fluor-dibenzo-b,f, tiepina.Info
- Publication number
- ES8306140A1 ES8306140A1 ES501935A ES501935A ES8306140A1 ES 8306140 A1 ES8306140 A1 ES 8306140A1 ES 501935 A ES501935 A ES 501935A ES 501935 A ES501935 A ES 501935A ES 8306140 A1 ES8306140 A1 ES 8306140A1
- Authority
- ES
- Spain
- Prior art keywords
- dibenzo
- fluoro
- hydroxy
- thiepin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Paints Or Removers (AREA)
- Organic Insulating Materials (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE LA 3-SUSTITUIDO-7-FLUOR-DIBENZO B,F TIEPINA Y DE SUS FORMAS ENANTIOMERAS PURAS, DE FORMULA (I), EN LA QUE N VALE DE 0 A 4; Z ES TIO, SULFINILO O SULFONILO; LA LINEA DE PUNTOS INDICA UN ENLACE OLEFINICO O SATURACION EN POSICION 10, 11; Y R PUEDE SER VARIOS RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION DE HIDROLISIS SE LLEVA A CABO EN UNA DISOLUCION ACUOSA DE UN ACIDO O UNA BASE FUERTE. EL COMPUESTO OBTENIDO SE PUEDE TRANSFORMAR EN OTRO EN EL QUE R ES DISTINTO DE HIDROXI. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL ASMA ALERGICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20943480A | 1980-11-24 | 1980-11-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8306140A1 true ES8306140A1 (es) | 1982-08-16 |
ES501935A0 ES501935A0 (es) | 1982-08-16 |
Family
ID=22778742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES501935A Granted ES501935A0 (es) | 1980-11-24 | 1981-05-06 | Un procedimiento para la preparacion de derivados de la 3-sustituido-7-fluor-dibenzo-b,f, tiepina. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0052912B1 (es) |
JP (1) | JPS5788176A (es) |
AT (1) | ATE11670T1 (es) |
CA (1) | CA1175846A (es) |
DE (1) | DE3168733D1 (es) |
DK (1) | DK168881A (es) |
ES (1) | ES501935A0 (es) |
FI (1) | FI811305L (es) |
GR (1) | GR75218B (es) |
IE (1) | IE51136B1 (es) |
NO (1) | NO811187L (es) |
NZ (1) | NZ196805A (es) |
PT (1) | PT73000B (es) |
ZA (1) | ZA812665B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4535171A (en) * | 1982-11-18 | 1985-08-13 | Merck Frosst Canada, Inc. | Dibenzo[b,f]thiepin-3-carboxaldehydes as prostaglandin antagonists |
US4622403A (en) * | 1983-10-11 | 1986-11-11 | Merck Frosst Canada, Inc. | 6-H dibenz[b,f]thiepin compounds |
CA1240699A (en) * | 1984-05-14 | 1988-08-16 | Thomas R. Verhoeven | Preparation of dibenzo(b,f)thiepin compounds |
US4558037A (en) * | 1984-06-04 | 1985-12-10 | Merck & Co., Inc. | Cardiovascular composition |
KR100769084B1 (ko) | 2005-02-17 | 2007-10-22 | 동우신테크 주식회사 | 디벤조티에핀 유도체의 제조 방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51108082A (en) * | 1975-03-15 | 1976-09-25 | Nippon Chemiphar Co | 99 karubokishi 10*111 jihidorojibenzo * b*f * chepinjudotainoseiho |
US4101667A (en) * | 1975-05-30 | 1978-07-18 | Nippon Chemiphar Co., Ltd. | Benzo[b,f]thiepin derivatives |
GB1487280A (en) * | 1975-11-06 | 1977-09-28 | Nippon Chemiphar Co | 10,11-dihydrodibenzo-(b,f)-thiepin-1-carboxylic acid derivatives and a process for producing the same |
JPS5346990A (en) * | 1976-10-06 | 1978-04-27 | Nippon Chemiphar Co Ltd | Dibenzo(d,f)thiepin derivatives and their preparation |
JPS5346989A (en) * | 1976-10-06 | 1978-04-27 | Nippon Chemiphar Co Ltd | Novel dibenzo(b,f)thiepin derivatives and their preparation |
PT68303A (en) * | 1977-07-26 | 1978-08-01 | Merck & Co Inc | Process for the preparation of dibenzo/b,f/thiepin |
FI801638A (fi) * | 1979-06-01 | 1980-12-02 | Merck & Co Inc | Prostaglandinantagonister |
-
1981
- 1981-04-07 NO NO811187A patent/NO811187L/no unknown
- 1981-04-08 IE IE798/81A patent/IE51136B1/en unknown
- 1981-04-13 NZ NZ196805A patent/NZ196805A/xx unknown
- 1981-04-13 GR GR64677A patent/GR75218B/el unknown
- 1981-04-13 CA CA000375371A patent/CA1175846A/en not_active Expired
- 1981-04-14 EP EP81301640A patent/EP0052912B1/en not_active Expired
- 1981-04-14 AT AT81301640T patent/ATE11670T1/de not_active IP Right Cessation
- 1981-04-14 DE DE8181301640T patent/DE3168733D1/de not_active Expired
- 1981-04-14 DK DK168881A patent/DK168881A/da not_active IP Right Cessation
- 1981-04-23 ZA ZA00812665A patent/ZA812665B/xx unknown
- 1981-04-27 FI FI811305A patent/FI811305L/fi not_active Application Discontinuation
- 1981-05-06 ES ES501935A patent/ES501935A0/es active Granted
- 1981-05-08 PT PT73000A patent/PT73000B/pt unknown
- 1981-05-14 JP JP56071560A patent/JPS5788176A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA1175846A (en) | 1984-10-09 |
NO811187L (no) | 1982-05-25 |
ZA812665B (en) | 1982-04-28 |
EP0052912A1 (en) | 1982-06-02 |
IE51136B1 (en) | 1986-10-15 |
ATE11670T1 (de) | 1985-02-15 |
PT73000A (en) | 1981-06-01 |
FI811305L (fi) | 1982-05-25 |
IE810798L (en) | 1982-05-24 |
GR75218B (es) | 1984-07-13 |
JPS5788176A (en) | 1982-06-01 |
NZ196805A (en) | 1983-07-15 |
DE3168733D1 (en) | 1985-03-21 |
PT73000B (en) | 1983-02-08 |
ES501935A0 (es) | 1982-08-16 |
EP0052912B1 (en) | 1985-02-06 |
DK168881A (da) | 1982-05-25 |
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