ES8306140A1 - Un procedimiento para la preparacion de derivados de la 3-sustituido-7-fluor-dibenzo-b,f, tiepina. - Google Patents

Un procedimiento para la preparacion de derivados de la 3-sustituido-7-fluor-dibenzo-b,f, tiepina.

Info

Publication number
ES8306140A1
ES8306140A1 ES501935A ES501935A ES8306140A1 ES 8306140 A1 ES8306140 A1 ES 8306140A1 ES 501935 A ES501935 A ES 501935A ES 501935 A ES501935 A ES 501935A ES 8306140 A1 ES8306140 A1 ES 8306140A1
Authority
ES
Spain
Prior art keywords
dibenzo
fluoro
hydroxy
thiepin
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501935A
Other languages
English (en)
Other versions
ES501935A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8306140A1 publication Critical patent/ES8306140A1/es
Publication of ES501935A0 publication Critical patent/ES501935A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Paints Or Removers (AREA)
  • Organic Insulating Materials (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE LA 3-SUSTITUIDO-7-FLUOR-DIBENZO B,F TIEPINA Y DE SUS FORMAS ENANTIOMERAS PURAS, DE FORMULA (I), EN LA QUE N VALE DE 0 A 4; Z ES TIO, SULFINILO O SULFONILO; LA LINEA DE PUNTOS INDICA UN ENLACE OLEFINICO O SATURACION EN POSICION 10, 11; Y R PUEDE SER VARIOS RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION DE HIDROLISIS SE LLEVA A CABO EN UNA DISOLUCION ACUOSA DE UN ACIDO O UNA BASE FUERTE. EL COMPUESTO OBTENIDO SE PUEDE TRANSFORMAR EN OTRO EN EL QUE R ES DISTINTO DE HIDROXI. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL ASMA ALERGICO.
ES501935A 1980-11-24 1981-05-06 Un procedimiento para la preparacion de derivados de la 3-sustituido-7-fluor-dibenzo-b,f, tiepina. Granted ES501935A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20943480A 1980-11-24 1980-11-24

Publications (2)

Publication Number Publication Date
ES8306140A1 true ES8306140A1 (es) 1982-08-16
ES501935A0 ES501935A0 (es) 1982-08-16

Family

ID=22778742

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501935A Granted ES501935A0 (es) 1980-11-24 1981-05-06 Un procedimiento para la preparacion de derivados de la 3-sustituido-7-fluor-dibenzo-b,f, tiepina.

Country Status (14)

Country Link
EP (1) EP0052912B1 (es)
JP (1) JPS5788176A (es)
AT (1) ATE11670T1 (es)
CA (1) CA1175846A (es)
DE (1) DE3168733D1 (es)
DK (1) DK168881A (es)
ES (1) ES501935A0 (es)
FI (1) FI811305L (es)
GR (1) GR75218B (es)
IE (1) IE51136B1 (es)
NO (1) NO811187L (es)
NZ (1) NZ196805A (es)
PT (1) PT73000B (es)
ZA (1) ZA812665B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535171A (en) * 1982-11-18 1985-08-13 Merck Frosst Canada, Inc. Dibenzo[b,f]thiepin-3-carboxaldehydes as prostaglandin antagonists
US4622403A (en) * 1983-10-11 1986-11-11 Merck Frosst Canada, Inc. 6-H dibenz[b,f]thiepin compounds
CA1240699A (en) * 1984-05-14 1988-08-16 Thomas R. Verhoeven Preparation of dibenzo(b,f)thiepin compounds
US4558037A (en) * 1984-06-04 1985-12-10 Merck & Co., Inc. Cardiovascular composition
KR100769084B1 (ko) 2005-02-17 2007-10-22 동우신테크 주식회사 디벤조티에핀 유도체의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108082A (en) * 1975-03-15 1976-09-25 Nippon Chemiphar Co 99 karubokishi 10*111 jihidorojibenzo * b*f * chepinjudotainoseiho
US4101667A (en) * 1975-05-30 1978-07-18 Nippon Chemiphar Co., Ltd. Benzo[b,f]thiepin derivatives
GB1487280A (en) * 1975-11-06 1977-09-28 Nippon Chemiphar Co 10,11-dihydrodibenzo-(b,f)-thiepin-1-carboxylic acid derivatives and a process for producing the same
JPS5346990A (en) * 1976-10-06 1978-04-27 Nippon Chemiphar Co Ltd Dibenzo(d,f)thiepin derivatives and their preparation
JPS5346989A (en) * 1976-10-06 1978-04-27 Nippon Chemiphar Co Ltd Novel dibenzo(b,f)thiepin derivatives and their preparation
PT68303A (en) * 1977-07-26 1978-08-01 Merck & Co Inc Process for the preparation of dibenzo/b,f/thiepin
FI801638A (fi) * 1979-06-01 1980-12-02 Merck & Co Inc Prostaglandinantagonister

Also Published As

Publication number Publication date
CA1175846A (en) 1984-10-09
NO811187L (no) 1982-05-25
ZA812665B (en) 1982-04-28
EP0052912A1 (en) 1982-06-02
IE51136B1 (en) 1986-10-15
ATE11670T1 (de) 1985-02-15
PT73000A (en) 1981-06-01
FI811305L (fi) 1982-05-25
IE810798L (en) 1982-05-24
GR75218B (es) 1984-07-13
JPS5788176A (en) 1982-06-01
NZ196805A (en) 1983-07-15
DE3168733D1 (en) 1985-03-21
PT73000B (en) 1983-02-08
ES501935A0 (es) 1982-08-16
EP0052912B1 (en) 1985-02-06
DK168881A (da) 1982-05-25

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