ES8104202A1 - Procedimiento para la preparacion de un derivado insulinico - Google Patents
Procedimiento para la preparacion de un derivado insulinicoInfo
- Publication number
- ES8104202A1 ES8104202A1 ES493550A ES493550A ES8104202A1 ES 8104202 A1 ES8104202 A1 ES 8104202A1 ES 493550 A ES493550 A ES 493550A ES 493550 A ES493550 A ES 493550A ES 8104202 A1 ES8104202 A1 ES 8104202A1
- Authority
- ES
- Spain
- Prior art keywords
- insulin
- preparation
- derivative
- monoalkylpolyethyleneglycol
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO INSULINICO, EN EL QUE EL GRUPO ALFA-AMINO DE LA CADENA B DE LA INSULINA ESTA UNIDO CON MONOALCOHILPOLIETILENGLICOL A TRAVES DE UN MIEMBRO ADECUADO. SE CARACERIZA PORQUE UNA INSULINA PROVISTA CON GRUPOS PROTECTORES EN LAS POSICIONES N ALFA A1 Y N EPSILON B29 SE HACE REACCIONAR CON UN DERIVADO DE ALCOHILPOLIETILENGLICOL, Y POSTERIORMENTE SE SEPARAN LOS GRUPOS PROTECTORES. ESTE COMPUESTO PRESENTA INTERES FARACOLOGICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19792930542 DE2930542A1 (de) | 1979-07-27 | 1979-07-27 | Neue insulinderivate und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8104202A1 true ES8104202A1 (es) | 1981-04-16 |
ES493550A0 ES493550A0 (es) | 1981-04-16 |
Family
ID=6076963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES493550A Granted ES493550A0 (es) | 1979-07-27 | 1980-07-21 | Procedimiento para la preparacion de un derivado insulinico |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0027161B1 (es) |
JP (1) | JPS5622326A (es) |
AT (1) | ATE3145T1 (es) |
CA (1) | CA1156217A (es) |
DE (2) | DE2930542A1 (es) |
DK (1) | DK324380A (es) |
ES (1) | ES493550A0 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985003934A1 (en) * | 1984-03-06 | 1985-09-12 | Takeda Chemical Industries, Ltd. | Chemically modified protein and process for its preparation |
DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
US5286637A (en) * | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6323311B1 (en) * | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
DK2599502T3 (en) | 2003-04-11 | 2017-04-18 | Antriabio Inc | Process for Preparation of Site-Specific Protein Conjugates |
JP4919384B2 (ja) * | 2005-12-14 | 2012-04-18 | 株式会社フジタ | 既存鋼製構造物の補強方法 |
CN101511391B (zh) | 2006-07-25 | 2013-03-13 | 利普生技术有限公司 | N末端聚唾液酸化 |
JP4859118B2 (ja) * | 2006-08-01 | 2012-01-25 | 株式会社フジタ | 既存鋼構造部材の補強工法 |
JP4895284B2 (ja) * | 2006-11-10 | 2012-03-14 | 株式会社フジタ | 既存鋼構造部材の補強構造 |
US10188739B2 (en) | 2014-02-27 | 2019-01-29 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
CN107446038A (zh) * | 2016-06-01 | 2017-12-08 | 湖南华腾制药有限公司 | 聚乙二醇修饰的重组人胰岛素及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2038121A1 (de) * | 1970-07-31 | 1972-02-03 | Hoechst Ag | Acylderivate des Insulins und Verfahren zu ihrer Herstellung |
DE2047413C3 (de) * | 1970-09-26 | 1980-05-29 | F. Hoffmann-La Roche & Co Ag, Basel (Schweiz) | Verfahren zur Herstellung von Peptiden in homogener Phase |
DE2433883C2 (de) * | 1973-07-20 | 1986-03-27 | Research Corp., New York, N.Y. | Verwendung von physiologisch aktiven Polypeptiden |
DE2360794C2 (de) * | 1973-12-06 | 1984-12-06 | Hoechst Ag, 6230 Frankfurt | Verfahren zur Herstellung von Peptiden |
-
1979
- 1979-07-27 DE DE19792930542 patent/DE2930542A1/de not_active Withdrawn
-
1980
- 1980-07-19 EP EP80104267A patent/EP0027161B1/de not_active Expired
- 1980-07-19 AT AT80104267T patent/ATE3145T1/de not_active IP Right Cessation
- 1980-07-19 DE DE8080104267T patent/DE3062890D1/de not_active Expired
- 1980-07-21 ES ES493550A patent/ES493550A0/es active Granted
- 1980-07-25 DK DK324380A patent/DK324380A/da not_active Application Discontinuation
- 1980-07-25 JP JP10137080A patent/JPS5622326A/ja active Pending
- 1980-07-25 CA CA000357096A patent/CA1156217A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3062890D1 (en) | 1983-06-01 |
ATE3145T1 (de) | 1983-05-15 |
EP0027161B1 (de) | 1983-04-27 |
CA1156217A (en) | 1983-11-01 |
ES493550A0 (es) | 1981-04-16 |
DK324380A (da) | 1981-01-28 |
DE2930542A1 (de) | 1981-02-12 |
EP0027161A1 (de) | 1981-04-22 |
JPS5622326A (en) | 1981-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971001 |