ES8104202A1 - Procedimiento para la preparacion de un derivado insulinico - Google Patents

Procedimiento para la preparacion de un derivado insulinico

Info

Publication number
ES8104202A1
ES8104202A1 ES493550A ES493550A ES8104202A1 ES 8104202 A1 ES8104202 A1 ES 8104202A1 ES 493550 A ES493550 A ES 493550A ES 493550 A ES493550 A ES 493550A ES 8104202 A1 ES8104202 A1 ES 8104202A1
Authority
ES
Spain
Prior art keywords
insulin
preparation
derivative
monoalkylpolyethyleneglycol
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493550A
Other languages
English (en)
Other versions
ES493550A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8104202A1 publication Critical patent/ES8104202A1/es
Publication of ES493550A0 publication Critical patent/ES493550A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO INSULINICO, EN EL QUE EL GRUPO ALFA-AMINO DE LA CADENA B DE LA INSULINA ESTA UNIDO CON MONOALCOHILPOLIETILENGLICOL A TRAVES DE UN MIEMBRO ADECUADO. SE CARACERIZA PORQUE UNA INSULINA PROVISTA CON GRUPOS PROTECTORES EN LAS POSICIONES N ALFA A1 Y N EPSILON B29 SE HACE REACCIONAR CON UN DERIVADO DE ALCOHILPOLIETILENGLICOL, Y POSTERIORMENTE SE SEPARAN LOS GRUPOS PROTECTORES. ESTE COMPUESTO PRESENTA INTERES FARACOLOGICO.
ES493550A 1979-07-27 1980-07-21 Procedimiento para la preparacion de un derivado insulinico Granted ES493550A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792930542 DE2930542A1 (de) 1979-07-27 1979-07-27 Neue insulinderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8104202A1 true ES8104202A1 (es) 1981-04-16
ES493550A0 ES493550A0 (es) 1981-04-16

Family

ID=6076963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493550A Granted ES493550A0 (es) 1979-07-27 1980-07-21 Procedimiento para la preparacion de un derivado insulinico

Country Status (7)

Country Link
EP (1) EP0027161B1 (es)
JP (1) JPS5622326A (es)
AT (1) ATE3145T1 (es)
CA (1) CA1156217A (es)
DE (2) DE2930542A1 (es)
DK (1) DK324380A (es)
ES (1) ES493550A0 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985003934A1 (en) * 1984-03-06 1985-09-12 Takeda Chemical Industries, Ltd. Chemically modified protein and process for its preparation
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
US5286637A (en) * 1989-08-07 1994-02-15 Debiopharm, S.A. Biologically active drug polymer derivatives and method for preparing same
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6323311B1 (en) * 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
DK2599502T3 (en) 2003-04-11 2017-04-18 Antriabio Inc Process for Preparation of Site-Specific Protein Conjugates
JP4919384B2 (ja) * 2005-12-14 2012-04-18 株式会社フジタ 既存鋼製構造物の補強方法
CN101511391B (zh) 2006-07-25 2013-03-13 利普生技术有限公司 N末端聚唾液酸化
JP4859118B2 (ja) * 2006-08-01 2012-01-25 株式会社フジタ 既存鋼構造部材の補強工法
JP4895284B2 (ja) * 2006-11-10 2012-03-14 株式会社フジタ 既存鋼構造部材の補強構造
US10188739B2 (en) 2014-02-27 2019-01-29 Xenetic Biosciences, Inc. Compositions and methods for administering insulin or insulin-like protein to the brain
CN107446038A (zh) * 2016-06-01 2017-12-08 湖南华腾制药有限公司 聚乙二醇修饰的重组人胰岛素及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038121A1 (de) * 1970-07-31 1972-02-03 Hoechst Ag Acylderivate des Insulins und Verfahren zu ihrer Herstellung
DE2047413C3 (de) * 1970-09-26 1980-05-29 F. Hoffmann-La Roche & Co Ag, Basel (Schweiz) Verfahren zur Herstellung von Peptiden in homogener Phase
DE2433883C2 (de) * 1973-07-20 1986-03-27 Research Corp., New York, N.Y. Verwendung von physiologisch aktiven Polypeptiden
DE2360794C2 (de) * 1973-12-06 1984-12-06 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von Peptiden

Also Published As

Publication number Publication date
DE3062890D1 (en) 1983-06-01
ATE3145T1 (de) 1983-05-15
EP0027161B1 (de) 1983-04-27
CA1156217A (en) 1983-11-01
ES493550A0 (es) 1981-04-16
DK324380A (da) 1981-01-28
DE2930542A1 (de) 1981-02-12
EP0027161A1 (de) 1981-04-22
JPS5622326A (en) 1981-03-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001