ES8103741A1 - Procedimiento para la preparacion de acidos 5-(2-hidroxi-3- tiopropoxi)-cromon-2-carboxilicos - Google Patents

Procedimiento para la preparacion de acidos 5-(2-hidroxi-3- tiopropoxi)-cromon-2-carboxilicos

Info

Publication number
ES8103741A1
ES8103741A1 ES490234A ES490234A ES8103741A1 ES 8103741 A1 ES8103741 A1 ES 8103741A1 ES 490234 A ES490234 A ES 490234A ES 490234 A ES490234 A ES 490234A ES 8103741 A1 ES8103741 A1 ES 8103741A1
Authority
ES
Spain
Prior art keywords
carbon atoms
thiopropoxy
hydroxy
carboxylic acids
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490234A
Other languages
English (en)
Other versions
ES490234A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CM Industries SA
Clin Midy
Original Assignee
CM Industries SA
Clin Midy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CM Industries SA, Clin Midy filed Critical CM Industries SA
Publication of ES8103741A1 publication Critical patent/ES8103741A1/es
Publication of ES490234A0 publication Critical patent/ES490234A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ACIDOS 5-(2-HIDROXI-3-TIOPROPOXI)-CROMONA-2-CARBOXILICOS DE FORMULA GENERAL: DONDE R PUEDE ADOPTAR DIVERSOS TIPOS DE RADICALES. CONSISTE EN HACER REACCIONAR UN OXALATO DIALCOHILICO INFERIOR DE FORMULA (COOR ELEVADO A 0)2 CON UNA 2-HIDROXI-6-(2-HIDROXI-3-TIOPROPOXI)-ACETOFENONA, EN PRESENCIA DE UN AGENTE DE CONDENSACION ALCALINO. EL COMPUESTO OBTENIDO SE TRATA CON UN ACIDO, OBTENIENDOSE EL COMPUESTO; POR HIDROLISIS DE ESTE COMPUESTO SE OBTIENE EL COMPUESTO DESEADO. R ELEVADO A 0 ES UN GRUPO ALCOHILO QUE TIENE DE 1 A 4 ATOMOS DE CARBONO. ESTOS COMPUESTOS TIENEN APLICACION COMO ANTIALERGICOS Y ANTIANAFILACTICOS. *FORMULA* P
ES490234A 1979-04-06 1980-04-02 Procedimiento para la preparacion de acidos 5-(2-hidroxi-3- tiopropoxi)-cromon-2-carboxilicos Granted ES490234A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7908859A FR2453170A1 (fr) 1979-04-06 1979-04-06 Acides 5-(2-hydroxy-3-thiopropoxy)chromone-2-carboxyliques et leurs applications comme medicaments presentant notamment des proprietes antianaphylactiques et antiallergiques

Publications (2)

Publication Number Publication Date
ES8103741A1 true ES8103741A1 (es) 1981-03-16
ES490234A0 ES490234A0 (es) 1981-03-16

Family

ID=9224100

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490234A Granted ES490234A0 (es) 1979-04-06 1980-04-02 Procedimiento para la preparacion de acidos 5-(2-hidroxi-3- tiopropoxi)-cromon-2-carboxilicos

Country Status (18)

Country Link
US (1) US4282247A (es)
EP (1) EP0017578B1 (es)
JP (1) JPS55139374A (es)
AR (1) AR223371A1 (es)
AT (1) ATE2840T1 (es)
CA (1) CA1140932A (es)
DE (1) DE3062403D1 (es)
EG (1) EG14469A (es)
ES (1) ES490234A0 (es)
FR (1) FR2453170A1 (es)
GR (1) GR64510B (es)
HK (1) HK8484A (es)
HU (1) HU181687B (es)
IN (1) IN153826B (es)
PH (1) PH14548A (es)
SG (1) SG64083G (es)
SU (1) SU923369A3 (es)
YU (1) YU41918B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2592653A1 (fr) * 1986-01-03 1987-07-10 Sanofi Sa Derives de chromene, procede d'obtention et compositions pharmaceutiques.
BR0206512A (pt) * 2001-01-16 2004-01-06 Astrazeneca Ab Composto, método de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de um composto, e, processo para preparar um composto.
EP1353914A2 (en) 2001-01-16 2003-10-22 AstraZeneca AB Therapeutic chromone compounds
CN1821236B (zh) * 2001-01-16 2010-06-23 阿斯特拉曾尼卡有限公司 治疗性杂环化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1093673A (en) * 1963-09-27 1967-12-06 Benger Lab Ltd Novel chromone carboxylic acids
NL140730B (nl) * 1963-09-27 1974-01-15 Fisons Pharmaceuticals Ltd Werkwijze voor de bereiding van gesubstitueerde chromoncabonzuur-2-derivaten met remmende werking op anafylactische reacties.
GB1147976A (en) * 1965-12-21 1969-04-10 Fisons Pharmaceuticals Ltd Chromone derivatives
GB1223690A (en) * 1967-10-17 1971-03-03 Fisons Pharmaceuticals Ltd Substituted chromon-2-carboxylic acids
YU35250B (en) * 1970-08-25 1980-10-31 Fisons Ltd Process for obtaining 4-oxo-4h-1-benzopyran derivatives
US3965122A (en) * 1970-12-30 1976-06-22 Fujisawa Pharmaceutical Co., Ltd. Chromone compounds and preparation thereof

Also Published As

Publication number Publication date
PH14548A (en) 1981-09-24
YU41918B (en) 1988-02-29
DE3062403D1 (en) 1983-04-28
SG64083G (en) 1985-12-13
HK8484A (en) 1984-02-10
US4282247A (en) 1981-08-04
FR2453170A1 (fr) 1980-10-31
SU923369A3 (ru) 1982-04-23
HU181687B (en) 1983-11-28
GR64510B (en) 1980-04-03
JPS6212795B2 (es) 1987-03-20
EP0017578B1 (fr) 1983-03-23
ES490234A0 (es) 1981-03-16
CA1140932A (en) 1983-02-08
AR223371A1 (es) 1981-08-14
EG14469A (en) 1984-09-30
JPS55139374A (en) 1980-10-31
EP0017578A1 (fr) 1980-10-15
YU93980A (en) 1983-02-28
ATE2840T1 (de) 1983-04-15
FR2453170B1 (es) 1983-06-24
IN153826B (es) 1984-08-18

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