ES8102100A1 - Procedimiento para la preparacion de nuevas 2-fenilimino-i- midazolidinas disustituidas en 3,4 - Google Patents
Procedimiento para la preparacion de nuevas 2-fenilimino-i- midazolidinas disustituidas en 3,4Info
- Publication number
- ES8102100A1 ES8102100A1 ES486970A ES486970A ES8102100A1 ES 8102100 A1 ES8102100 A1 ES 8102100A1 ES 486970 A ES486970 A ES 486970A ES 486970 A ES486970 A ES 486970A ES 8102100 A1 ES8102100 A1 ES 8102100A1
- Authority
- ES
- Spain
- Prior art keywords
- fluoro
- acid addition
- group
- imidazolidines
- phenylimino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 3,4-Disubstituted 2-phenylimino-imidazolidines Chemical class 0.000 title abstract 13
- 239000002253 acid Substances 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000007792 addition Methods 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HKWFCVUHNYCCNR-UHFFFAOYSA-N 1-n-(4,5-dihydro-1h-imidazol-2-yl)-4-fluorobenzene-1,3-diamine Chemical compound C1=C(F)C(N)=CC(N=C2NCCN2)=C1 HKWFCVUHNYCCNR-UHFFFAOYSA-N 0.000 abstract 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- NHDLMBUAIWPQQA-UHFFFAOYSA-N n-(4-fluoro-3-nitrophenyl)-4,5-dihydro-1h-imidazol-2-amine Chemical compound C1=C(F)C([N+](=O)[O-])=CC(NC=2NCCN=2)=C1 NHDLMBUAIWPQQA-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Luminescent Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782854659 DE2854659A1 (de) | 1978-12-18 | 1978-12-18 | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES486970A0 ES486970A0 (es) | 1980-12-16 |
| ES8102100A1 true ES8102100A1 (es) | 1980-12-16 |
Family
ID=6057553
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES486970A Expired ES8102100A1 (es) | 1978-12-18 | 1979-12-17 | Procedimiento para la preparacion de nuevas 2-fenilimino-i- midazolidinas disustituidas en 3,4 |
| ES486967A Granted ES486967A0 (es) | 1978-12-18 | 1979-12-17 | Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas disustituidas en 3,4 |
| ES486971A Granted ES486971A0 (es) | 1978-12-18 | 1979-12-17 | Procedimiento para la preparacion de una nueva 2-(4-fluoro-3-amino fenilimino)-imidazolidina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES486967A Granted ES486967A0 (es) | 1978-12-18 | 1979-12-17 | Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas disustituidas en 3,4 |
| ES486971A Granted ES486971A0 (es) | 1978-12-18 | 1979-12-17 | Procedimiento para la preparacion de una nueva 2-(4-fluoro-3-amino fenilimino)-imidazolidina |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0012822B1 (esLanguage) |
| JP (1) | JPS5583754A (esLanguage) |
| AT (1) | ATE1903T1 (esLanguage) |
| AU (1) | AU526539B2 (esLanguage) |
| CA (1) | CA1112648A (esLanguage) |
| DE (2) | DE2854659A1 (esLanguage) |
| DK (1) | DK146821C (esLanguage) |
| ES (3) | ES8102100A1 (esLanguage) |
| FI (1) | FI68814C (esLanguage) |
| GR (1) | GR73913B (esLanguage) |
| IE (1) | IE49239B1 (esLanguage) |
| IL (1) | IL58971A (esLanguage) |
| NO (1) | NO148555C (esLanguage) |
| NZ (1) | NZ192426A (esLanguage) |
| PH (1) | PH22130A (esLanguage) |
| PT (1) | PT70592A (esLanguage) |
| YU (1) | YU41901B (esLanguage) |
| ZA (1) | ZA796832B (esLanguage) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2933930A1 (de) * | 1979-08-22 | 1981-03-12 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-chlor-4-cyclopropyl-phenylimino)-imidazolidin, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben. |
| HU192986B (en) * | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
| AU704972B2 (en) | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
| DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| TR199901484T2 (xx) * | 1996-11-25 | 1999-09-21 | The Procter & Gamble Company | 2-Amino-2-imidazolin, guanidin ve 2-amino-3,4,5,6-tetrahidropirimidin t�revleri haz�rlama i�lemi. |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US6066740A (en) * | 1997-11-25 | 2000-05-23 | The Procter & Gamble Company | Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives |
| CN111303038A (zh) * | 2020-03-18 | 2020-06-19 | 滨州德润化工有限责任公司 | 一种油田水处理用缓蚀剂两性咪唑啉制作工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL123037C (esLanguage) * | 1963-10-04 | |||
| BE687656A (esLanguage) * | 1965-10-01 | 1967-03-30 | ||
| DE1545628A1 (de) * | 1965-10-01 | 1970-06-25 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von blutdrucksenkend und sedativ wirksamen Derivaten des 2-(2-Halogenanilino)-1,3-diazacyclopentens-(2) |
| AT278775B (de) * | 1967-01-19 | 1970-02-10 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von Δ<2>-Imidazolinderivaten und ihren Salzen |
| AT330769B (de) * | 1974-04-05 | 1976-07-26 | Chemie Linz Ag | Verfahren zur herstellung von 2-arylamino- 2-imidazolin-derivaten und ihren salzen |
| DE2806775A1 (de) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
-
1978
- 1978-12-18 DE DE19782854659 patent/DE2854659A1/de not_active Withdrawn
-
1979
- 1979-11-08 EP EP79104381A patent/EP0012822B1/de not_active Expired
- 1979-11-08 DE DE7979104381T patent/DE2964166D1/de not_active Expired
- 1979-11-08 AT AT79104381T patent/ATE1903T1/de not_active IP Right Cessation
- 1979-11-28 GR GR60628A patent/GR73913B/el unknown
- 1979-12-13 PT PT70592A patent/PT70592A/pt unknown
- 1979-12-17 JP JP16289679A patent/JPS5583754A/ja active Granted
- 1979-12-17 NO NO794114A patent/NO148555C/no unknown
- 1979-12-17 YU YU3089/79A patent/YU41901B/xx unknown
- 1979-12-17 AU AU53893/79A patent/AU526539B2/en not_active Ceased
- 1979-12-17 IE IE2447/79A patent/IE49239B1/en unknown
- 1979-12-17 ES ES486970A patent/ES8102100A1/es not_active Expired
- 1979-12-17 NZ NZ192426A patent/NZ192426A/en unknown
- 1979-12-17 FI FI793948A patent/FI68814C/fi not_active IP Right Cessation
- 1979-12-17 ES ES486967A patent/ES486967A0/es active Granted
- 1979-12-17 ES ES486971A patent/ES486971A0/es active Granted
- 1979-12-17 IL IL58971A patent/IL58971A/xx unknown
- 1979-12-17 CA CA342,041A patent/CA1112648A/en not_active Expired
- 1979-12-17 DK DK537179A patent/DK146821C/da not_active IP Right Cessation
- 1979-12-18 ZA ZA00796832A patent/ZA796832B/xx unknown
-
1983
- 1983-03-22 PH PH28680A patent/PH22130A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU41901B (en) | 1988-02-29 |
| NO148555C (no) | 1983-11-23 |
| FI793948A7 (fi) | 1980-06-19 |
| JPH0118071B2 (esLanguage) | 1989-04-03 |
| PT70592A (de) | 1980-01-01 |
| PH22130A (en) | 1988-06-01 |
| ES8100272A1 (es) | 1980-11-01 |
| DE2854659A1 (de) | 1980-07-10 |
| ES486970A0 (es) | 1980-12-16 |
| ES8103054A1 (es) | 1981-02-16 |
| ATE1903T1 (de) | 1982-12-15 |
| DK146821C (da) | 1984-06-25 |
| NO148555B (no) | 1983-07-25 |
| NZ192426A (en) | 1984-07-06 |
| AU5389379A (en) | 1980-06-26 |
| YU308979A (en) | 1983-04-30 |
| DK146821B (da) | 1984-01-16 |
| ES486971A0 (es) | 1980-11-01 |
| EP0012822B1 (de) | 1982-12-01 |
| IE792447L (en) | 1980-06-18 |
| CA1112648A (en) | 1981-11-17 |
| JPS5583754A (en) | 1980-06-24 |
| ES486967A0 (es) | 1981-02-16 |
| EP0012822A1 (de) | 1980-07-09 |
| FI68814C (fi) | 1985-11-11 |
| ZA796832B (en) | 1981-08-26 |
| NO794114L (no) | 1980-06-19 |
| FI68814B (fi) | 1985-07-31 |
| IE49239B1 (en) | 1985-09-04 |
| IL58971A (en) | 1984-03-30 |
| GR73913B (esLanguage) | 1984-05-22 |
| DK537179A (da) | 1980-06-19 |
| IL58971A0 (en) | 1980-03-31 |
| DE2964166D1 (en) | 1983-01-05 |
| AU526539B2 (en) | 1983-01-20 |
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