ES8101585A1 - Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico - Google Patents
Procedimiento de obtencion de un nuevo compuesto antiateros-cleroticoInfo
- Publication number
- ES8101585A1 ES8101585A1 ES488665A ES488665A ES8101585A1 ES 8101585 A1 ES8101585 A1 ES 8101585A1 ES 488665 A ES488665 A ES 488665A ES 488665 A ES488665 A ES 488665A ES 8101585 A1 ES8101585 A1 ES 8101585A1
- Authority
- ES
- Spain
- Prior art keywords
- hyperlipoproteinaemia
- isobutyrate
- para
- hypolipaemic
- hypocholesterolaemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 title abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 title abstract 2
- 235000001968 nicotinic acid Nutrition 0.000 title abstract 2
- 239000011664 nicotinic acid Substances 0.000 title abstract 2
- 125000005456 glyceride group Chemical group 0.000 title 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 title 1
- 230000000055 hyoplipidemic effect Effects 0.000 title 1
- 230000000871 hypocholesterolemic effect Effects 0.000 title 1
- 230000036470 plasma concentration Effects 0.000 title 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 abstract 1
- 229960001214 clofibrate Drugs 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES488665A ES8101585A1 (es) | 1980-02-15 | 1980-02-15 | Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico |
| FR8017235A FR2476095A1 (en) | 1980-02-15 | 1980-08-01 | Glyceryl 2-para-chloro:phenoxy-isobutyrate-1,3-di:nicotinate - hypolipaemic and hypocholesterolaemic used to treat atherosclerosis, hyperlipoproteinaemia and high tri:glyceride plasma levels |
| BE2/58700A BE884722A (fr) | 1980-02-15 | 1980-08-12 | Nouvel ester mixte symetrique de 1,2,3-trihydroxypropane, son procede d'obtention et ses applications therapeutiques |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES488665A ES8101585A1 (es) | 1980-02-15 | 1980-02-15 | Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES488665A0 ES488665A0 (es) | 1980-12-16 |
| ES8101585A1 true ES8101585A1 (es) | 1980-12-16 |
Family
ID=8479833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488665A Expired ES8101585A1 (es) | 1980-02-15 | 1980-02-15 | Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE884722A (cg-RX-API-DMAC10.html) |
| ES (1) | ES8101585A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2476095A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692262B1 (fr) * | 1992-06-10 | 1994-08-05 | Adir | Nouveaux nicotinates de diacylglycerols, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| MEP27808A (en) | 2001-01-26 | 2010-10-10 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| ATE331512T1 (de) | 2001-01-26 | 2006-07-15 | Schering Corp | Verwendung azetidinone-substituierter verbindungen zur behandlung der sitosterolhämie |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| WO2004043457A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| CA2517571C (en) | 2003-03-07 | 2011-07-05 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| EP1606287B1 (en) | 2003-03-07 | 2013-10-02 | Merck Sharp & Dohme Corp. | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| MXPA05009501A (es) | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| EP2134169A2 (en) | 2007-03-09 | 2009-12-23 | Indigene Pharmaceuticals Inc. | Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications |
| TN2017000344A1 (en) | 2015-02-06 | 2019-01-16 | Intercept Pharmaceuticals Inc | Pharmaceutical compositions for combination therapy |
| KR20220016146A (ko) | 2019-05-30 | 2022-02-08 | 인터셉트 파마슈티컬즈, 인크. | 담즙정체성 간 질환의 치료에서 사용하기 위한 fxr 효능제 및 피브레이트를 포함하는 제약 조성물 |
-
1980
- 1980-02-15 ES ES488665A patent/ES8101585A1/es not_active Expired
- 1980-08-01 FR FR8017235A patent/FR2476095A1/fr active Granted
- 1980-08-12 BE BE2/58700A patent/BE884722A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE884722A (fr) | 1980-12-01 |
| FR2476095A1 (en) | 1981-08-21 |
| FR2476095B1 (cg-RX-API-DMAC10.html) | 1984-03-09 |
| ES488665A0 (es) | 1980-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 19991217 |