ES540638A0 - Un procedimiento de preparar 5,6,7,8-tetrahidro-6-(l-eritro-1',2'-dihidroxipropil)-pterina. - Google Patents

Un procedimiento de preparar 5,6,7,8-tetrahidro-6-(l-eritro-1',2'-dihidroxipropil)-pterina.

Info

Publication number
ES540638A0
ES540638A0 ES540638A ES540638A ES540638A0 ES 540638 A0 ES540638 A0 ES 540638A0 ES 540638 A ES540638 A ES 540638A ES 540638 A ES540638 A ES 540638A ES 540638 A0 ES540638 A0 ES 540638A0
Authority
ES
Spain
Prior art keywords
preparing
dihidroxipropil
eritro
pterine
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES540638A
Other languages
English (en)
Spanish (es)
Other versions
ES8601993A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12397654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES540638(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of ES8601993A1 publication Critical patent/ES8601993A1/es
Publication of ES540638A0 publication Critical patent/ES540638A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES540638A 1984-02-23 1985-02-22 Un procedimiento de preparar 5,6,7,8-tetrahidro-6-(l-eritro-1',2'-dihidroxipropil)-pterina. Granted ES540638A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59033839A JPS60178887A (ja) 1984-02-23 1984-02-23 ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法

Publications (2)

Publication Number Publication Date
ES8601993A1 ES8601993A1 (es) 1985-11-16
ES540638A0 true ES540638A0 (es) 1985-11-16

Family

ID=12397654

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540638A Granted ES540638A0 (es) 1984-02-23 1985-02-22 Un procedimiento de preparar 5,6,7,8-tetrahidro-6-(l-eritro-1',2'-dihidroxipropil)-pterina.

Country Status (7)

Country Link
US (1) US4595752A (forum.php)
EP (1) EP0153696B1 (forum.php)
JP (1) JPS60178887A (forum.php)
AT (1) ATE46906T1 (forum.php)
CA (1) CA1240321A (forum.php)
DE (1) DE3573426D1 (forum.php)
ES (1) ES540638A0 (forum.php)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60199889A (ja) * 1984-03-24 1985-10-09 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法
JPS60204786A (ja) * 1984-03-29 1985-10-16 Univ Nagoya （６ｒ）―テトラヒドロビオプテリンの合成法
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
CA1262347A (en) * 1985-01-28 1989-10-17 Suntory Limited Preparation process of (6r)-tetrahydro-l-biopterin
US4937342A (en) * 1987-11-30 1990-06-26 Kabushiki Kaisha Vitamin Kenkyusyo Intermediates for synthesizing BH4 and its derivatives
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
CA2420374A1 (en) * 2000-08-31 2003-02-24 Suntory Limited Process for production of biopterin compound
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
BRPI0416566A (pt) * 2003-11-17 2007-01-23 Biomarin Pharm Inc tratamento de fenilcetonúrias com bh4
AU2004311544A1 (en) * 2003-11-17 2005-07-21 Merck & Cie Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
EP1768653A4 (en) * 2004-06-25 2012-08-01 Univ Texas METHOD AND COMPOSITIONS FOR TREATING ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY AND HYPERPHENYL ALANINEMIA
US8003126B2 (en) 2004-11-17 2011-08-23 Biomarin Pharmaceutical Inc. Stable tablet formulation
JP2008523090A (ja) * 2004-12-08 2008-07-03 バイオマリン ファーマシューティカル インコーポレイテッド 新生児肺高血圧症の治療のための方法および組成物
PL1869048T3 (pl) 2005-04-14 2009-05-29 Shiratori Pharmaceutical Co Ltd Sposób wytwarzania kryształów chlorowodorku sapropteryny w odmianie alfa
EP1965803A1 (en) * 2005-12-05 2008-09-10 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
US20100009997A1 (en) * 2007-01-12 2010-01-14 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
PT2139485E (pt) 2007-04-11 2013-01-16 Biomarin Pharm Inc Métodos de administração da tetra-hidrobiopterina, composições associadas e métodos de medição
BRPI0821970A2 (pt) 2008-01-03 2015-06-23 Biomarin Pharm Inc Análogos de pterina para tratamento de condição responsiva a bh4
CL2009000007A1 (es) * 2008-01-07 2010-02-19 Biomarin Pharm Inc Metodo para preparar biopterina por hidrolisis de diacetilbiopterina en presencia de una base en una mezcla bifasica de agua y un solvente organico inmiscible en agua a un ph de 10.
CN102443006B (zh) * 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) * 2010-10-15 2015-04-21 Innopharmax Inc （６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102627644B (zh) * 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2741608A (en) * 1951-03-08 1956-04-10 Research Corp 5-formyl-5,6,7,8-tetrahydropteroic acid and amides thereof and method of preparing same
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS61172876A (ja) * 1985-01-28 1986-08-04 Shiratori Seiyaku Kk （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造法
JPS61172877A (ja) * 1985-01-28 1986-08-04 Shiratori Seiyaku Kk （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法

Also Published As

Publication number Publication date
ES8601993A1 (es) 1985-11-16
CA1240321A (en) 1988-08-09
EP0153696A3 (en) 1987-08-19
JPS60178887A (ja) 1985-09-12
EP0153696A2 (en) 1985-09-04
EP0153696B1 (en) 1989-10-04
ATE46906T1 (de) 1989-10-15
DE3573426D1 (en) 1989-11-09
JPH0212475B2 (forum.php) 1990-03-20
US4595752A (en) 1986-06-17

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