ES480787A1 - Un procedimiento para preparar derivados de tetrahidrotiopi-rano (2,3-b) indol. - Google Patents

Un procedimiento para preparar derivados de tetrahidrotiopi-rano (2,3-b) indol.

Info

Publication number
ES480787A1
ES480787A1 ES480787A ES480787A ES480787A1 ES 480787 A1 ES480787 A1 ES 480787A1 ES 480787 A ES480787 A ES 480787A ES 480787 A ES480787 A ES 480787A ES 480787 A1 ES480787 A1 ES 480787A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
alkenyl
aryl
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480787A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES480787A1 publication Critical patent/ES480787A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)

Abstract

Un procedimiento para preparar derivados de tetrahidrotiopirano (2,3-b)indol de la fórmula I: **(Fórmula-01)** en la cual R1 es hidrógeno, alcohilo, hidroxialcohilo, alquenilo, aralcohilo, arilo, - COR5 (donde R5 es alcohilo, alquenilo, arilo o alcoxi) **(Fórmula-02)** (donde Y es alcohileno, oxoalcohileno, hidroxialcohileno y R6 y R7 son, casda una de ellas, hidrógeno o alcohilo); R2 es hidrógeno o alcohilo; R3 es hidrógeno, alcohilo, hidroxialcohilo, alquenilo, aralcohilo, arilo o dialcohilaminoalcohilo, ó **(Fórmula-03)** es pirrolidino, piperidino, piperazino, 4- alcohilpiperazino, 4 -arilpiperazino o morfolino; R4 es hidrógeno o alcohilo; A es metileno o alcohilmetileno; X es hidrógeno o uno o dos grupos seleccionados del grupo que consiste en halógeno, alcohilo, alcoxi, hidroxi y halógeno alcohilo; y n es 0 ó un entero de 1 ó 2, que comprende reducir un compuesto de la fórmula (e) **(Fórmula-04)** (en donde R1 y X tienen los mismos significados que se han definido anteriormente) paradar un compuesto de la fórmula (f) **(Fórmula-05)** (en donde R1 y X tienen los mismos significados que se han definido anteriormente); hacer que el compuesto de fórmula (f) reaccione con un aldehido, una cetona, o un haloformiato alcalino seguido por reducción y, si se desea, hacer que el producto reaccione con un aldehido en presencia de un agente reductor, oxidar el producto para dar el S-óxido o S-dióxido correspondiente y/o introducir un sustituyente en las posiciones 4 y/o 9 si R1 y/o R4 en la fórmula del producto son hidrógeno.
ES480787A 1978-05-23 1979-05-22 Un procedimiento para preparar derivados de tetrahidrotiopi-rano (2,3-b) indol. Expired ES480787A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6183278A JPS557201A (en) 1978-05-23 1978-05-23 Derivative of tetrahydrothiopyrano(2,3-b)indole

Publications (1)

Publication Number Publication Date
ES480787A1 true ES480787A1 (es) 1980-06-16

Family

ID=13182455

Family Applications (2)

Application Number Title Priority Date Filing Date
ES480787A Expired ES480787A1 (es) 1978-05-23 1979-05-22 Un procedimiento para preparar derivados de tetrahidrotiopi-rano (2,3-b) indol.
ES484683A Expired ES484683A1 (es) 1978-05-23 1979-10-03 Un procedimiento para preparar derivados de tetrahidrotiopi-rano (2,3-b)indol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES484683A Expired ES484683A1 (es) 1978-05-23 1979-10-03 Un procedimiento para preparar derivados de tetrahidrotiopi-rano (2,3-b)indol

Country Status (12)

Country Link
US (1) US4256640A (es)
JP (1) JPS557201A (es)
AU (1) AU522699B2 (es)
CA (1) CA1129413A (es)
DE (1) DE2921001A1 (es)
DK (1) DK207679A (es)
ES (2) ES480787A1 (es)
FR (1) FR2426689A1 (es)
GB (1) GB2030133B (es)
IT (1) IT7968088A0 (es)
NL (1) NL7904089A (es)
SE (1) SE7904493L (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56120686A (en) * 1980-02-27 1981-09-22 Shionogi & Co Ltd Tetrahydrothiopyrano 3,2-b indole derivative
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA015252B1 (ru) 2005-05-10 2011-06-30 Интермьюн, Инк. Способ модуляции стресс-активированной протеинкиназной системы
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类
US10537552B2 (en) 2015-05-05 2020-01-21 Carafe Drug Innovation, Llc Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE37060B1 (en) * 1972-01-13 1977-04-27 Ayerst Mckenna & Harrison Indole derivatives
US3880853A (en) * 1972-01-13 1975-04-29 Ayerst Mckenna & Harrison Pyrano-and thiopyranoindole
US3971806A (en) * 1974-05-09 1976-07-27 Warner-Lambert Company Indolothiopyrones

Also Published As

Publication number Publication date
DK207679A (da) 1979-11-24
AU522699B2 (en) 1982-06-24
DE2921001A1 (de) 1979-11-29
US4256640A (en) 1981-03-17
GB2030133A (en) 1980-04-02
NL7904089A (nl) 1979-11-27
AU4715479A (en) 1979-11-29
FR2426689A1 (fr) 1979-12-21
JPS557201A (en) 1980-01-19
FR2426689B1 (es) 1983-01-28
IT7968088A0 (it) 1979-05-22
GB2030133B (en) 1983-03-02
SE7904493L (sv) 1979-11-24
CA1129413A (en) 1982-08-10
ES484683A1 (es) 1980-06-16

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