ES474559A1 - Procedimiento para la obtencion de derivados del inhibidor de tripsina pancreatica basica - Google Patents
Procedimiento para la obtencion de derivados del inhibidor de tripsina pancreatica basicaInfo
- Publication number
- ES474559A1 ES474559A1 ES474559A ES474559A ES474559A1 ES 474559 A1 ES474559 A1 ES 474559A1 ES 474559 A ES474559 A ES 474559A ES 474559 A ES474559 A ES 474559A ES 474559 A1 ES474559 A1 ES 474559A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- bpti
- medicines
- inhibitor
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title 2
- 108010039627 Aprotinin Proteins 0.000 title 1
- 101000984722 Bos taurus Pancreatic trypsin inhibitor Proteins 0.000 abstract 2
- 102000001399 Kallikrein Human genes 0.000 abstract 2
- 108060005987 Kallikrein Proteins 0.000 abstract 2
- 229940122618 Trypsin inhibitor Drugs 0.000 abstract 2
- 101710162629 Trypsin inhibitor Proteins 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000002753 trypsin inhibitor Substances 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 150000001718 carbodiimides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000009615 deamination Effects 0.000 abstract 1
- 238000006481 deamination reaction Methods 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento para la obtención de derivados del inhibidor de tripsina pancreática básica, en los que solo una parte de los grupos carboxilo de la BPTI de origen natural o de sus derivados están modificados, caracterizado porque BPTI o derivados de la BPTI, que contienen grupos carboxilo libre, se hacen reaccionar con compuestos amino nucleófilos (con excepción del glicinetiléster) en presencia de carbodiimidas, a valores entre 3 y 11, en solución acuosa, que en caso dado contienen también disolventes orgánicos y/o sales y/o agentes de desnaturalización, los productos de reacción obtenidos se aíslan y en caso dado se separan, o los productos de reacción obtenidos a continuación se desaminizan con agentes suministradores de iones nitrosilo o con compuestos de diazonium no copuladores y/o en caso dado se transforman por reacción con compuestos de diazonium copulantes a valores pH entre 1 y 12, en compuestos azoicos y los productos de reacción que se forman en cada caso se aíslan según métodosen sí conocidos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772748295 DE2748295A1 (de) | 1977-10-27 | 1977-10-27 | Neue derivate des bpti |
Publications (1)
Publication Number | Publication Date |
---|---|
ES474559A1 true ES474559A1 (es) | 1979-10-16 |
Family
ID=6022457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES474559A Expired ES474559A1 (es) | 1977-10-27 | 1978-10-26 | Procedimiento para la obtencion de derivados del inhibidor de tripsina pancreatica basica |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0001774A1 (es) |
JP (1) | JPS5473702A (es) |
DE (1) | DE2748295A1 (es) |
DK (1) | DK477178A (es) |
ES (1) | ES474559A1 (es) |
IT (1) | IT7829122A0 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3135541A1 (de) * | 1981-09-08 | 1983-03-24 | Bayer Ag, 5090 Leverkusen | Kallikrein-trypsin-inhibitor-(bpti)-derivate, traegergebundene bpti-derivate, ihre herstellung und ihre verwendung zur herstellung der reinen enzyme trypsin, chymotrypsin und kallikrein |
JPS5921656A (ja) * | 1982-07-28 | 1984-02-03 | Takeda Chem Ind Ltd | ポリペプチド誘導体 |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
KR101320735B1 (ko) | 2006-03-01 | 2013-10-21 | 도진도 래보라토리즈 | 펩티드 지질-함유 담체 및 이를 이용하여 화합물을 세포 내로 도입하는 방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4729807U (es) * | 1971-04-26 | 1972-12-05 | ||
JPS5139212Y2 (es) * | 1973-02-24 | 1976-09-25 | ||
DE2619246A1 (de) * | 1976-04-30 | 1977-11-10 | Bayer Ag | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2654124A1 (de) * | 1976-11-29 | 1978-06-01 | Bayer Ag | Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel |
-
1977
- 1977-10-27 DE DE19772748295 patent/DE2748295A1/de active Pending
-
1978
- 1978-10-14 EP EP78101147A patent/EP0001774A1/de not_active Withdrawn
- 1978-10-25 JP JP13061478A patent/JPS5473702A/ja active Pending
- 1978-10-25 IT IT7829122A patent/IT7829122A0/it unknown
- 1978-10-26 DK DK477178A patent/DK477178A/da unknown
- 1978-10-26 ES ES474559A patent/ES474559A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0001774A1 (de) | 1979-05-16 |
IT7829122A0 (it) | 1978-10-25 |
DE2748295A1 (de) | 1979-05-03 |
JPS5473702A (en) | 1979-06-13 |
DK477178A (da) | 1979-04-28 |
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