ES473414A1 - Un proceso para la preparacion de eteres del acido clavula- nico - Google Patents

Un proceso para la preparacion de eteres del acido clavula- nico

Info

Publication number
ES473414A1
ES473414A1 ES473414A ES473414A ES473414A1 ES 473414 A1 ES473414 A1 ES 473414A1 ES 473414 A ES473414 A ES 473414A ES 473414 A ES473414 A ES 473414A ES 473414 A1 ES473414 A1 ES 473414A1
Authority
ES
Spain
Prior art keywords
hydrogen atom
preparation
pharmaceutical compositions
compositions containing
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES473414A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES473414A1 publication Critical patent/ES473414A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un proceso para la preparación de éteres del ácido clavulánico de fórmula (I) **fórmula** o una sal o éster del mismo dónde R1 es un átomo de hidrógeno o un grupo metilo, R2 es un átomo de hidrógeno o un grupo metilo y R3 es un átomo de hidrógeno o un grupo COR4, CO2R4 o CONR4R5 donde R4 es un grupo alquilo de hasta 6 átomos de carbono o un grupo fenilo o bencilo y R5 es un átomo de hidrógeno o un grupo alquilo de hasta seis átomos de carbono, cuyo proceso comprende la reacción de un éster de ácido clavulánico en presencia de un catalizador con un derivado de la aziridina de la fórmula (VI) **fórmula ** donde R1 y R2 son los definidos con relación a la fórmula (I) y R6 es un grupo CO.R4 , CO2R4 o CONR5 donde R4 y R5 son los definidos con relación a la fórmula (I) y después si se desea, realizar una o varias de las fases opcionales siguientes. (A) someter un compuesto de la fórmula (I) o un éster del mismo donde R3 es un grupo benciloxicarbonilo a hidrogenólisis para producir un compuesto dela fórmula (I) donde R3 es un átomo de hidrógeno. (B) escindir el éster para formar una sal o ácido. © esterificar una sal o ácido producido por la fase opcional (b).
ES473414A 1977-09-16 1978-09-15 Un proceso para la preparacion de eteres del acido clavula- nico Expired ES473414A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3864977 1977-09-16
GB2404778 1978-05-30

Publications (1)

Publication Number Publication Date
ES473414A1 true ES473414A1 (es) 1979-11-01

Family

ID=26256866

Family Applications (1)

Application Number Title Priority Date Filing Date
ES473414A Expired ES473414A1 (es) 1977-09-16 1978-09-15 Un proceso para la preparacion de eteres del acido clavula- nico

Country Status (19)

Country Link
JP (1) JPS5452093A (es)
AR (1) AR218504A1 (es)
AT (1) ATA664078A (es)
AU (1) AU3974778A (es)
CA (1) CA1121821A (es)
CH (1) CH640536A5 (es)
DE (1) DE2839426A1 (es)
DK (1) DK410378A (es)
ES (1) ES473414A1 (es)
FI (1) FI782791A (es)
FR (1) FR2403343A1 (es)
GB (1) GB2004541B (es)
GR (1) GR65657B (es)
IT (1) IT7851089A0 (es)
LU (1) LU80244A1 (es)
NL (1) NL7809400A (es)
NO (1) NO783132L (es)
PT (1) PT68513A (es)
SE (1) SE7809747L (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT66071B (en) * 1976-01-31 1978-06-23 Beecham Group Ltd Clavulanic acid thioethers
GB1587612A (en) * 1976-10-30 1981-04-08 Beecham Group Ltd Isoclavulanic acid derivatives
GB1595176A (en) * 1976-12-03 1981-08-12 Beecham Group Ltd Clavulanic acid ethers

Also Published As

Publication number Publication date
DE2839426A1 (de) 1979-03-29
JPS5452093A (en) 1979-04-24
IT7851089A0 (it) 1978-09-14
FR2403343B1 (es) 1980-06-13
NL7809400A (nl) 1979-03-20
SE7809747L (sv) 1979-03-17
CA1121821A (en) 1982-04-13
AR218504A1 (es) 1980-06-13
FR2403343A1 (fr) 1979-04-13
ATA664078A (de) 1982-06-15
GB2004541A (en) 1979-04-04
FI782791A (fi) 1979-03-17
NO783132L (no) 1979-03-19
CH640536A5 (de) 1984-01-13
AU3974778A (en) 1980-03-20
GR65657B (en) 1980-10-16
LU80244A1 (fr) 1979-03-07
PT68513A (en) 1978-10-01
GB2004541B (en) 1982-05-12
DK410378A (da) 1979-03-17

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