ES473381A1 - Procedimiento para la preparacion de nuevos derivados de prostaglandinas que contienen fluor. - Google Patents
Procedimiento para la preparacion de nuevos derivados de prostaglandinas que contienen fluor.Info
- Publication number
- ES473381A1 ES473381A1 ES473381A ES473381A ES473381A1 ES 473381 A1 ES473381 A1 ES 473381A1 ES 473381 A ES473381 A ES 473381A ES 473381 A ES473381 A ES 473381A ES 473381 A1 ES473381 A1 ES 473381A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- replaced
- denotes
- fluorinated
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento para la preparación de nuevos derivados de prostaglandinas que contienen flúor de la fórmula I **(Fórmula)** que están relacionados estructuralmente con las prostaglandinas naturales y en que X e Y significan justamente oxígeno o en cada caso hidrógeno o un grupo hidroxilo, siendo diferentes X e Y, R1 a) significa hidrógeno o un radical alifático o cicloalifático de cadena recta, ramificado, saturado o insaturado, con uno a diez átomos de carbono, en el que un grupo CH2 puede estar reemplazado por un átomo de oxígeno o un átomo de hidrógeno puede estar reemplazado en la que Z1 y Z2 significan un grupo CH2, un grupo -C(CH3)2 ó un enlace simple.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772742407 DE2742407A1 (de) | 1977-09-21 | 1977-09-21 | Neue fluorhaltige prostaglandinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES473381A1 true ES473381A1 (es) | 1979-04-16 |
Family
ID=6019473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES473381A Expired ES473381A1 (es) | 1977-09-21 | 1978-09-15 | Procedimiento para la preparacion de nuevos derivados de prostaglandinas que contienen fluor. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0001255B1 (es) |
| JP (1) | JPS5455554A (es) |
| AT (1) | ATA678178A (es) |
| AU (1) | AU526475B2 (es) |
| DE (2) | DE2742407A1 (es) |
| ES (1) | ES473381A1 (es) |
| IL (1) | IL55601A (es) |
| IT (1) | IT1100114B (es) |
| ZA (1) | ZA785289B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060135609A1 (en) | 2004-10-21 | 2006-06-22 | Duke University | Ophthamological drugs |
| US20070254920A1 (en) * | 2006-04-26 | 2007-11-01 | Aerie Pharmaceuticals, Inc. | Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA764727B (en) * | 1975-09-02 | 1977-07-27 | Upjohn Co | Prostanoic acid derivatives |
-
1977
- 1977-09-21 DE DE19772742407 patent/DE2742407A1/de not_active Withdrawn
-
1978
- 1978-09-13 DE DE7878100877T patent/DE2861236D1/de not_active Expired
- 1978-09-13 EP EP78100877A patent/EP0001255B1/de not_active Expired
- 1978-09-15 ES ES473381A patent/ES473381A1/es not_active Expired
- 1978-09-18 ZA ZA00785289A patent/ZA785289B/xx unknown
- 1978-09-19 IL IL55601A patent/IL55601A/xx unknown
- 1978-09-19 IT IT27853/78A patent/IT1100114B/it active
- 1978-09-20 AT AT0678178A patent/ATA678178A/de unknown
- 1978-09-20 AU AU40024/78A patent/AU526475B2/en not_active Expired
- 1978-09-21 JP JP11522678A patent/JPS5455554A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA785289B (en) | 1979-08-29 |
| IT1100114B (it) | 1985-09-28 |
| DE2742407A1 (de) | 1979-03-29 |
| ATA678178A (de) | 1983-02-15 |
| DE2861236D1 (en) | 1981-12-10 |
| AU526475B2 (en) | 1983-01-13 |
| EP0001255A1 (de) | 1979-04-04 |
| JPS5455554A (en) | 1979-05-02 |
| AU4002478A (en) | 1980-03-27 |
| IT7827853A0 (it) | 1978-09-19 |
| IL55601A (en) | 1983-03-31 |
| IL55601A0 (en) | 1978-12-17 |
| EP0001255B1 (de) | 1981-09-30 |
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