ES470825A1 - Un procedimiento para la preparacion de n-(3-(mercaptoaceti-lamino)benzoil)glicina - Google Patents
Un procedimiento para la preparacion de n-(3-(mercaptoaceti-lamino)benzoil)glicinaInfo
- Publication number
- ES470825A1 ES470825A1 ES470825A ES470825A ES470825A1 ES 470825 A1 ES470825 A1 ES 470825A1 ES 470825 A ES470825 A ES 470825A ES 470825 A ES470825 A ES 470825A ES 470825 A1 ES470825 A1 ES 470825A1
- Authority
- ES
- Spain
- Prior art keywords
- product
- glycine
- reacting
- mercaptoacylamidobenzoyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000004471 Glycine Substances 0.000 title abstract 2
- 230000000510 mucolytic effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- UDZHNOUYXZRNPF-UHFFFAOYSA-N 3-[(2-chloroacetyl)amino]benzoic acid Chemical compound OC(=O)C1=CC=CC(NC(=O)CCl)=C1 UDZHNOUYXZRNPF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- DUYAAUVXQSMXQP-UHFFFAOYSA-N ethanethioic S-acid Chemical compound CC(S)=O DUYAAUVXQSMXQP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- KQSSATDQUYCRGS-UHFFFAOYSA-N methyl glycinate Chemical compound COC(=O)CN KQSSATDQUYCRGS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/806,877 US4093739A (en) | 1977-06-15 | 1977-06-15 | Mercaptoacylamidobenzoyl glycine and mucolytic process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES470825A1 true ES470825A1 (es) | 1979-10-01 |
Family
ID=25195031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470825A Expired ES470825A1 (es) | 1977-06-15 | 1978-06-15 | Un procedimiento para la preparacion de n-(3-(mercaptoaceti-lamino)benzoil)glicina |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4093739A (enExample) |
| JP (1) | JPS545933A (enExample) |
| AU (1) | AU520094B2 (enExample) |
| BE (1) | BE868114A (enExample) |
| CA (1) | CA1132607A (enExample) |
| CH (1) | CH635067A5 (enExample) |
| DE (1) | DE2825931C2 (enExample) |
| DK (1) | DK268478A (enExample) |
| ES (1) | ES470825A1 (enExample) |
| FI (1) | FI71307C (enExample) |
| FR (1) | FR2394526A1 (enExample) |
| GB (1) | GB2001958B (enExample) |
| GR (1) | GR73530B (enExample) |
| IE (1) | IE46995B1 (enExample) |
| IT (1) | IT1107483B (enExample) |
| LU (1) | LU79805A1 (enExample) |
| NL (1) | NL7806360A (enExample) |
| PH (1) | PH13512A (enExample) |
| SE (1) | SE441526B (enExample) |
| YU (1) | YU40195B (enExample) |
| ZA (1) | ZA783443B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296500A (en) * | 1991-08-30 | 1994-03-22 | The Procter & Gamble Company | Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy |
| SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
| EP0655461B1 (en) * | 1993-11-16 | 2000-06-07 | Novartis AG | Cyclic amino acid derivatives having ACE and NEP inhibiting activity |
| US5432186A (en) * | 1993-11-16 | 1995-07-11 | Ciba-Geigy Corporation | Cyclic amino acid derivatives |
| US5451405A (en) * | 1994-04-25 | 1995-09-19 | Chesebrough-Pond's Usa Co. | Skin treatment composition |
| JP3261969B2 (ja) * | 1996-02-29 | 2002-03-04 | 豊田合成株式会社 | ホースとその製造方法 |
| US6294695B1 (en) | 1998-03-26 | 2001-09-25 | Mount Sinai School Of Medicine Of The City University Of New York | Aminobenzoic acid derivatives having anti-tumorigenic activity methods of making and using the same |
| JP2003106051A (ja) * | 2001-09-28 | 2003-04-09 | Tostem Corp | サッシ |
| US6797319B2 (en) * | 2002-05-31 | 2004-09-28 | Kimberly-Clark Worldwide, Inc. | Application of foam to tissue products using a liquid permeable partition |
| EP3678739B1 (en) | 2017-09-07 | 2024-03-13 | The Children's Hospital of Philadelphia | Compositions and methods for treatment of hereditary cystatin c amyloid angiopathy ( hccaa) and other neurodegenerative disorders associated with aberrant amyloid deposits |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2520293A (en) * | 1947-01-30 | 1950-08-29 | Endo Products Inc | Mercaptoacetanilide derivatives |
| US3091569A (en) * | 1960-08-26 | 1963-05-28 | Mead Johnson & Co | Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus |
| US3663690A (en) * | 1969-08-12 | 1972-05-16 | Hoechst Co American | Mucolytic composition and method of treatment of broncho-pulmonary disorders therewith |
| BE789811A (fr) * | 1971-10-07 | 1973-04-06 | Bristol Myers Co | 1,4-bis-acylpiperazines |
| BE789838A (fr) * | 1971-10-13 | 1973-02-01 | Cerm Cent Europ Rech Mauvernay | Nouveaux derives de la cysteine et leur application en therapeutique |
| FR2187327B1 (enExample) * | 1972-06-15 | 1975-06-20 | Rech Pharm Scientifiques | |
| US3971828A (en) * | 1972-10-03 | 1976-07-27 | Santen Pharmaceutical Co. Ltd. | N-(mercaptoacyl)aminoacids |
| US3857951A (en) * | 1973-09-14 | 1974-12-31 | Cassenne Lab Sa | Use of 2-mercaptopropionylglycine and its alkali metal salts in treating respiratory diseases |
| US4005222A (en) * | 1975-05-21 | 1977-01-25 | Mead Johnson & Company | Mucolytic mercaptoacylamidobenzoic and benzenesulfonic acid compounds and process |
-
1977
- 1977-06-15 US US05/806,877 patent/US4093739A/en not_active Expired - Lifetime
-
1978
- 1978-03-24 US US05/889,674 patent/US4132803A/en not_active Expired - Lifetime
- 1978-04-21 CA CA301,723A patent/CA1132607A/en not_active Expired
- 1978-06-09 YU YU1375/78A patent/YU40195B/xx unknown
- 1978-06-10 GR GR56494A patent/GR73530B/el unknown
- 1978-06-12 FI FI781866A patent/FI71307C/fi not_active IP Right Cessation
- 1978-06-12 NL NL7806360A patent/NL7806360A/xx not_active Application Discontinuation
- 1978-06-13 JP JP7046078A patent/JPS545933A/ja active Granted
- 1978-06-13 LU LU79805A patent/LU79805A1/xx unknown
- 1978-06-14 AU AU37112/78A patent/AU520094B2/en not_active Expired
- 1978-06-14 SE SE7806880A patent/SE441526B/sv not_active IP Right Cessation
- 1978-06-14 FR FR7817799A patent/FR2394526A1/fr active Granted
- 1978-06-14 BE BE188564A patent/BE868114A/xx not_active IP Right Cessation
- 1978-06-14 IT IT49864/78A patent/IT1107483B/it active
- 1978-06-14 DE DE2825931A patent/DE2825931C2/de not_active Expired
- 1978-06-14 IE IE1194/78A patent/IE46995B1/en unknown
- 1978-06-14 DK DK268478A patent/DK268478A/da not_active Application Discontinuation
- 1978-06-14 GB GB7826928A patent/GB2001958B/en not_active Expired
- 1978-06-15 ZA ZA00783443A patent/ZA783443B/xx unknown
- 1978-06-15 ES ES470825A patent/ES470825A1/es not_active Expired
- 1978-06-15 CH CH655278A patent/CH635067A5/de not_active IP Right Cessation
- 1978-06-19 PH PH21281A patent/PH13512A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6225657B2 (enExample) | 1987-06-04 |
| IE46995B1 (en) | 1983-11-30 |
| DK268478A (da) | 1978-12-16 |
| IT7849864A0 (it) | 1978-06-14 |
| ZA783443B (en) | 1979-06-27 |
| FR2394526A1 (fr) | 1979-01-12 |
| GB2001958B (en) | 1982-02-03 |
| AU3711278A (en) | 1979-12-20 |
| LU79805A1 (fr) | 1979-02-02 |
| GB2001958A (en) | 1979-02-14 |
| JPS545933A (en) | 1979-01-17 |
| SE7806880L (sv) | 1978-12-16 |
| IE781194L (en) | 1978-12-15 |
| US4132803A (en) | 1979-01-02 |
| FI781866A7 (fi) | 1978-12-16 |
| IT1107483B (it) | 1985-11-25 |
| SE441526B (sv) | 1985-10-14 |
| AU520094B2 (en) | 1982-01-14 |
| US4093739A (en) | 1978-06-06 |
| FR2394526B1 (enExample) | 1980-07-04 |
| DE2825931C2 (de) | 1987-01-29 |
| PH13512A (en) | 1980-06-03 |
| BE868114A (fr) | 1978-12-14 |
| CA1132607A (en) | 1982-09-28 |
| YU137578A (en) | 1983-01-21 |
| NL7806360A (nl) | 1978-12-19 |
| GR73530B (enExample) | 1984-03-12 |
| YU40195B (en) | 1985-08-31 |
| CH635067A5 (de) | 1983-03-15 |
| DE2825931A1 (de) | 1979-01-04 |
| FI71307C (fi) | 1986-12-19 |
| FI71307B (fi) | 1986-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001204 |