ES469425A1 - Un procedimiento para la preparacion de derivados de tiena- micina - Google Patents
Un procedimiento para la preparacion de derivados de tiena- micinaInfo
- Publication number
- ES469425A1 ES469425A1 ES469425A ES469425A ES469425A1 ES 469425 A1 ES469425 A1 ES 469425A1 ES 469425 A ES469425 A ES 469425A ES 469425 A ES469425 A ES 469425A ES 469425 A1 ES469425 A1 ES 469425A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- compounds
- thienamycin
- acyl derivatives
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/793,974 US4235917A (en) | 1977-05-05 | 1977-05-05 | N-Alkyl-N-acyl derivatives of thienamycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES469425A1 true ES469425A1 (es) | 1980-01-01 |
Family
ID=25161301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES469425A Expired ES469425A1 (es) | 1977-05-05 | 1978-05-03 | Un procedimiento para la preparacion de derivados de tiena- micina |
Country Status (14)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839352A (en) * | 1975-11-21 | 1989-06-13 | Merck & Co., Inc. | N-acyl derivatives of thienamycin |
| US4318912A (en) * | 1979-01-02 | 1982-03-09 | Merck & Co., Inc. | 6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid |
| US4376774A (en) * | 1979-05-29 | 1983-03-15 | Merck & Co., Inc. | Antibiotic N-heterocyclyl thienamycin |
| EP0055990B1 (en) * | 1979-08-10 | 1986-06-11 | Beecham Group Plc | Beta-lactam antibiotics, their preparation and use |
| US4361512A (en) * | 1980-11-26 | 1982-11-30 | Merck & Co., Inc. | 2-Substituted thio-6-substituted-carbapen-2-em-3-carboxylic acids |
| JPS5857392A (ja) * | 1981-10-02 | 1983-04-05 | Sanraku Inc | 新規な抗生物質ｏａ−６１２９のリン酸エステル |
| US4710568A (en) * | 1982-04-09 | 1987-12-01 | Bristol-Myers Company | Carbapenem antibiotics |
| ZA832412B (en) * | 1982-04-09 | 1983-12-28 | Bristol Myers Co | Carbapenem antibiotics |
| US4552696A (en) * | 1982-04-09 | 1985-11-12 | Bristol-Myers Company | Carbapenem antibiotics |
| US4642341A (en) * | 1982-04-09 | 1987-02-10 | Bristol-Myers Company | Carbapenem antibiotics |
| US4529597A (en) * | 1982-04-19 | 1985-07-16 | Merck & Co., Inc. | Substituted 1-azabicyclo(3.2.0)hept-6-en-2-one-7-carboxylic acids |
| US4536335A (en) * | 1982-06-18 | 1985-08-20 | Bristol-Myers Company | Carbapenem antibiotics |
| US4665170A (en) * | 1982-06-18 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
| US4640799A (en) * | 1982-06-18 | 1987-02-03 | Bristol-Myers Company | Carbapenem antibiotics |
| JPS5910588A (ja) * | 1982-06-18 | 1984-01-20 | ブリストル―マイヤーズ スクイブ カンパニー | カルバペネム抗生物質 |
| US4732977A (en) * | 1982-09-28 | 1988-03-22 | Bristol Myers Company | Carbapenem antibiotics |
| US4746736A (en) * | 1982-09-28 | 1988-05-24 | Bristol-Myers Company | Carbapenem antibiotics |
| ZM1484A1 (en) * | 1983-03-08 | 1984-12-21 | Bristol Myers Co | Carbapenem process |
| US4992542A (en) * | 1984-01-24 | 1991-02-12 | Merck & Co., Inc. | 2-substituted-6-carbadethiapen-2-em-3-carboxylic acids |
| US5496816A (en) * | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950357A (en) * | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
| CH632508A5 (de) * | 1975-11-21 | 1982-10-15 | Merck & Co Inc | Verfahren zur herstellung von neuen estern des n-acylierten thienamycins. |
| US4150145A (en) * | 1977-09-15 | 1979-04-17 | Merck & Co., Inc. | N-alkylated derivatives of thienamycin sulfoxide and sulfone |
-
1977
- 1977-05-05 US US05/793,974 patent/US4235917A/en not_active Expired - Lifetime
-
1978
- 1978-04-19 SE SE7804446A patent/SE7804446L/xx unknown
- 1978-04-19 DK DK170678A patent/DK170678A/da active IP Right Grant
- 1978-04-20 NL NL7804230A patent/NL7804230A/xx not_active Application Discontinuation
- 1978-05-03 DE DE19782819479 patent/DE2819479A1/de active Granted
- 1978-05-03 ES ES469425A patent/ES469425A1/es not_active Expired
- 1978-05-03 FR FR7813128A patent/FR2389629B1/fr not_active Expired
- 1978-05-03 IT IT49175/78A patent/IT1105291B/it active
- 1978-05-03 BE BE187350A patent/BE866660A/xx not_active IP Right Cessation
- 1978-05-03 GB GB17441/78A patent/GB1604276A/en not_active Expired
- 1978-05-03 CH CH483978A patent/CH638209A5/de not_active IP Right Cessation
- 1978-05-04 IE IE899/78A patent/IE46877B1/en unknown
- 1978-05-05 LU LU79597A patent/LU79597A1/xx unknown
- 1978-05-06 JP JP5331178A patent/JPS53137992A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2389629A1 (US20090163788A1-20090625-C00002.png) | 1978-12-01 |
| DE2819479A1 (de) | 1978-11-16 |
| IT7849175A0 (it) | 1978-05-03 |
| CH638209A5 (de) | 1983-09-15 |
| IE780899L (en) | 1978-11-05 |
| SE7804446L (sv) | 1978-11-06 |
| GB1604276A (en) | 1981-12-09 |
| JPS53137992A (en) | 1978-12-01 |
| IT1105291B (it) | 1985-10-28 |
| NL7804230A (nl) | 1978-11-07 |
| IE46877B1 (en) | 1983-10-19 |
| FR2389629B1 (US20090163788A1-20090625-C00002.png) | 1980-06-20 |
| LU79597A1 (fr) | 1979-02-02 |
| US4235917A (en) | 1980-11-25 |
| DK170678A (da) | 1979-01-16 |
| JPH0222076B2 (US20090163788A1-20090625-C00002.png) | 1990-05-17 |
| DE2819479C2 (US20090163788A1-20090625-C00002.png) | 1992-04-30 |
| BE866660A (fr) | 1978-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991108 |