ES468132A1 - Propanolamine derivatives - Google Patents

Propanolamine derivatives

Info

Publication number
ES468132A1
ES468132A1 ES468132A ES468132A ES468132A1 ES 468132 A1 ES468132 A1 ES 468132A1 ES 468132 A ES468132 A ES 468132A ES 468132 A ES468132 A ES 468132A ES 468132 A1 ES468132 A1 ES 468132A1
Authority
ES
Spain
Prior art keywords
aerosol
chamber
box
fluid
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468132A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH375177A external-priority patent/CH633521A5/en
Priority claimed from CH375377A external-priority patent/CH628021A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES468132A1 publication Critical patent/ES468132A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/38—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Improvements in aerosol interface devices, particularly suitable for respiratory therapeutic applications, characterized in that each device is provided with a box that defines a fluid receiving box in open communication with the atmosphere, an admission device that works in association with the box for allow continuous feeding to the chamber of an aerosol fluid flow to obtain an accumulation of the aerosol fluid therein to be inhaled by a patient using the aerosol interface, a breathing transmission device operating in association with the box and has a conduit passing through it, whose conduit is defined by an interior opening at one end in communication with the chamber and extending above the intake device and an outer opening at its other end with an upper and lower surface extending intermediate to the ends, the opening being intended to establish communication with the breathing of a patient using the aerosol interface for inhalation through the aerosol fluid passage in the chamber and exhalation of exhaled fluid by the patient into the duct, an associated functioning output device with the box in open communication with the camera and with the atmosphere, whose output device comprises a channel to allow the establishment of a flow path for the fluid expired by the patient so that it escapes into the atmosphere, and a regulating device flow defined at one end of the intermediate chamber to the transmission device and to the output device to make virtually all the flow expired during exhalation from the interior opening of the conduit flow in open communication to the atmosphere through the channel of the device exit without flowing into the interior of the chamber. (Machine-translation by Google Translate, not legally binding)
ES468132A 1977-03-24 1978-03-22 Propanolamine derivatives Expired ES468132A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH375177A CH633521A5 (en) 1977-03-24 1977-03-24 Process for preparing novel 3-amino-2-hydroxypropoxy derivatives
CH375377A CH628021A5 (en) 1977-03-24 1977-03-24 Process for the preparation of 3-amino-2-hydroxypropoxy derivatives

Publications (1)

Publication Number Publication Date
ES468132A1 true ES468132A1 (en) 1979-07-01

Family

ID=25693765

Family Applications (1)

Application Number Title Priority Date Filing Date
ES468132A Expired ES468132A1 (en) 1977-03-24 1978-03-22 Propanolamine derivatives

Country Status (19)

Country Link
JP (1) JPS53149960A (en)
AT (1) AT370720B (en)
AU (1) AU521709B2 (en)
CA (1) CA1119190A (en)
DE (1) DE2810869A1 (en)
DK (1) DK117578A (en)
ES (1) ES468132A1 (en)
FI (1) FI780820A (en)
FR (1) FR2384740A1 (en)
GB (1) GB1597886A (en)
IE (1) IE46590B1 (en)
IL (1) IL54327A (en)
IT (1) IT1104178B (en)
NL (1) NL7802975A (en)
NZ (1) NZ186758A (en)
PH (1) PH13897A (en)
PT (1) PT67807A (en)
SE (1) SE7802972L (en)
SU (1) SU959622A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU516491B2 (en) * 1978-11-06 1981-06-04 Nippon Steel Corporation Continuous casting
FR2507181A1 (en) * 1981-06-05 1982-12-10 Sanofi Sa NOVEL ETHERS OF PHENOL ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESS FOR PREPARING THEM AND USE THEREOF IN MEDICAMENTS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641152A (en) * 1968-09-23 1972-02-08 Warner Lambert Pharmaceutical 3 4-dihydronaphthalenoneoxy-2-hydroxy-propylamines
CH621330A5 (en) * 1976-05-14 1981-01-30 Sandoz Ag

Also Published As

Publication number Publication date
NZ186758A (en) 1980-10-24
DE2810869A1 (en) 1978-09-28
AU3442678A (en) 1979-09-27
FI780820A (en) 1978-09-25
GB1597886A (en) 1981-09-16
FR2384740A1 (en) 1978-10-20
IT7848558A0 (en) 1978-03-23
CA1119190A (en) 1982-03-02
AT370720B (en) 1983-04-25
JPS53149960A (en) 1978-12-27
PH13897A (en) 1980-10-27
IL54327A0 (en) 1978-06-15
IT1104178B (en) 1985-10-21
DK117578A (en) 1978-09-25
SE7802972L (en) 1978-09-25
ATA207178A (en) 1982-09-15
SU959622A3 (en) 1982-09-15
FR2384740B1 (en) 1980-06-20
PT67807A (en) 1978-04-01
IL54327A (en) 1982-09-30
NL7802975A (en) 1978-09-26
IE46590B1 (en) 1983-07-27
AU521709B2 (en) 1982-04-29
IE780577L (en) 1978-09-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503