FR2384740A1 - NEW DERIVATIVES OF AMINO-PROPANE-2-OL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS - Google Patents

NEW DERIVATIVES OF AMINO-PROPANE-2-OL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Info

Publication number
FR2384740A1
FR2384740A1 FR7808108A FR7808108A FR2384740A1 FR 2384740 A1 FR2384740 A1 FR 2384740A1 FR 7808108 A FR7808108 A FR 7808108A FR 7808108 A FR7808108 A FR 7808108A FR 2384740 A1 FR2384740 A1 FR 2384740A1
Authority
FR
France
Prior art keywords
amino
preparation
propane
application
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7808108A
Other languages
French (fr)
Other versions
FR2384740B1 (en
Inventor
Trevor Glyn Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH375177A external-priority patent/CH633521A5/en
Priority claimed from CH375377A external-priority patent/CH628021A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2384740A1 publication Critical patent/FR2384740A1/en
Application granted granted Critical
Publication of FR2384740B1 publication Critical patent/FR2384740B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/38—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de l'amino-propane-2-ol et leur préparation. Les composés de l'invention répondent à la formule :The invention relates to novel derivatives of amino-propan-2-ol and their preparation. The compounds of the invention correspond to the formula:

FR7808108A 1977-03-24 1978-03-21 NEW DERIVATIVES OF AMINO-PROPANE-2-OL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS Granted FR2384740A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH375177A CH633521A5 (en) 1977-03-24 1977-03-24 Process for preparing novel 3-amino-2-hydroxypropoxy derivatives
CH375377A CH628021A5 (en) 1977-03-24 1977-03-24 Process for the preparation of 3-amino-2-hydroxypropoxy derivatives

Publications (2)

Publication Number Publication Date
FR2384740A1 true FR2384740A1 (en) 1978-10-20
FR2384740B1 FR2384740B1 (en) 1980-06-20

Family

ID=25693765

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7808108A Granted FR2384740A1 (en) 1977-03-24 1978-03-21 NEW DERIVATIVES OF AMINO-PROPANE-2-OL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Country Status (19)

Country Link
JP (1) JPS53149960A (en)
AT (1) AT370720B (en)
AU (1) AU521709B2 (en)
CA (1) CA1119190A (en)
DE (1) DE2810869A1 (en)
DK (1) DK117578A (en)
ES (1) ES468132A1 (en)
FI (1) FI780820A (en)
FR (1) FR2384740A1 (en)
GB (1) GB1597886A (en)
IE (1) IE46590B1 (en)
IL (1) IL54327A (en)
IT (1) IT1104178B (en)
NL (1) NL7802975A (en)
NZ (1) NZ186758A (en)
PH (1) PH13897A (en)
PT (1) PT67807A (en)
SE (1) SE7802972L (en)
SU (1) SU959622A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507181A1 (en) * 1981-06-05 1982-12-10 Sanofi Sa NOVEL ETHERS OF PHENOL ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESS FOR PREPARING THEM AND USE THEREOF IN MEDICAMENTS

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU516491B2 (en) * 1978-11-06 1981-06-04 Nippon Steel Corporation Continuous casting

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2018626A1 (en) * 1968-09-23 1970-06-26 Warner Lambert Pharmaceutical
FR2351091A1 (en) * 1976-05-14 1977-12-09 Sandoz Sa NEW DERIVATIVES OF PROPYLENEGLYCOL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2018626A1 (en) * 1968-09-23 1970-06-26 Warner Lambert Pharmaceutical
FR2351091A1 (en) * 1976-05-14 1977-12-09 Sandoz Sa NEW DERIVATIVES OF PROPYLENEGLYCOL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507181A1 (en) * 1981-06-05 1982-12-10 Sanofi Sa NOVEL ETHERS OF PHENOL ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESS FOR PREPARING THEM AND USE THEREOF IN MEDICAMENTS
EP0067106A1 (en) * 1981-06-05 1982-12-15 Elf Sanofi Phenol ethers active on the cardiovascular system, process for their preparation and their use in medicines

Also Published As

Publication number Publication date
IE780577L (en) 1978-09-24
ES468132A1 (en) 1979-07-01
AU3442678A (en) 1979-09-27
SU959622A3 (en) 1982-09-15
PH13897A (en) 1980-10-27
ATA207178A (en) 1982-09-15
DK117578A (en) 1978-09-25
FR2384740B1 (en) 1980-06-20
CA1119190A (en) 1982-03-02
AU521709B2 (en) 1982-04-29
PT67807A (en) 1978-04-01
AT370720B (en) 1983-04-25
NZ186758A (en) 1980-10-24
FI780820A (en) 1978-09-25
IL54327A (en) 1982-09-30
IT1104178B (en) 1985-10-21
DE2810869A1 (en) 1978-09-28
NL7802975A (en) 1978-09-26
IT7848558A0 (en) 1978-03-23
JPS53149960A (en) 1978-12-27
GB1597886A (en) 1981-09-16
IE46590B1 (en) 1983-07-27
SE7802972L (en) 1978-09-25
IL54327A0 (en) 1978-06-15

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