ES464533A2 - Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico - Google Patents
Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilicoInfo
- Publication number
- ES464533A2 ES464533A2 ES464533A ES464533A ES464533A2 ES 464533 A2 ES464533 A2 ES 464533A2 ES 464533 A ES464533 A ES 464533A ES 464533 A ES464533 A ES 464533A ES 464533 A2 ES464533 A2 ES 464533A2
- Authority
- ES
- Spain
- Prior art keywords
- carboxylic acid
- manufacture
- acid anilide
- methyl isoxazole
- anilide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZYEWRBNSDKQNSJ-UHFFFAOYSA-N 5-methyl-n-phenyl-1,2-oxazole-4-carboxamide Chemical class O1N=CC(C(=O)NC=2C=CC=CC=2)=C1C ZYEWRBNSDKQNSJ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- VQBXUKGMJCPBMF-UHFFFAOYSA-N 5-methyl-1,2-oxazole-4-carboxylic acid Chemical class CC=1ON=CC=1C(O)=O VQBXUKGMJCPBMF-UHFFFAOYSA-N 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mejoras introducidas en el objeto de la Patente principal número 448.386 solicitada el 31 de Mayo de 1976 por: "Procedimiento para la preparación de anilidas de ácido 5-metil-isoxazol-4- carboxílico", según las cuales cuando dichas anilidas responden a la fórmula I **(Fórmula)** en donde R1, R2 y R3 pueden ser iguales o diferentes, y significan alcohilo con 1, 2 ó 3 átomos de carbono, alcoxicon 1, 2 ó 3 átomos de carbono, alcohiltio con 1, 2 ó 3 átomos de carbono, los cuales grupos, en cada caso, pueden estar sustituidos total o parcialmente con átomos de halógeno iguales o diferentes, o significan halógeno, nitro, ciano, carbalcoxi con 1, 2 ó 3 átomos de carbono en el grupo alcohilo, en donde R1 y R2 significan además hidrógeno, en cuyo caso, sin embargo, R3 no puede ser metilo, pero en cuyo caso R3 significa adicionalmente fenilo, que eventualmente puede estar sustituido en cada caso una vez o dos veces con flúor, cloro, bromo, yodo, alcohilo con 1, 2 ó 3 átomos de carbono, o fenoxi.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762654797 DE2654797A1 (de) | 1976-12-03 | 1976-12-03 | Verfahren zur herstellung von isoxazolderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES464533A2 true ES464533A2 (es) | 1979-10-16 |
Family
ID=5994582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES464533A Expired ES464533A2 (es) | 1976-12-03 | 1977-11-28 | Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5371068A (es) |
| AT (1) | AT361917B (es) |
| BE (1) | BE861500R (es) |
| CA (1) | CA1095056A (es) |
| CH (1) | CH609341A5 (es) |
| DE (1) | DE2654797A1 (es) |
| DK (1) | DK538777A (es) |
| ES (1) | ES464533A2 (es) |
| FR (1) | FR2381756A2 (es) |
| GB (1) | GB1572309A (es) |
| IE (1) | IE46001B1 (es) |
| IT (1) | IT1089430B (es) |
| LU (1) | LU78614A1 (es) |
| NL (1) | NL7713083A (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980000964A1 (en) * | 1978-11-03 | 1980-05-15 | American Cyanamid Co | Anti-inflammatory agents including 2-carbonyl-3-hydroxy-2-alkenonitriles |
| EP0035285A3 (en) * | 1979-08-17 | 1981-10-14 | American Cyanamid Company | Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters |
| DE2854438A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Isoxazolderivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende mittel und ihre verwendung |
| DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| IL60269A (en) * | 1979-06-11 | 1983-12-30 | Ciba Geigy | Alpha-carbamoyl-pyrrolpropionitriles,their preparation and pharmaceutical compositions containing them |
| DE3247454A1 (de) * | 1982-12-22 | 1984-06-28 | Laboratorios Bago S.A., Buenos Aires | Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB8619432D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2525023A1 (de) * | 1975-06-05 | 1976-12-16 | Hoechst Ag | Neue isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende fungizide |
| NL178596C (nl) * | 1975-06-05 | 1986-04-16 | Hoechst Ag | Werkwijze voor het bereiden van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor het bereiden van daarin als geneeskrachtige verbindingen te gebruiken 5-methylisoxazool-4-carbonzuuraniliden. |
-
1976
- 1976-12-03 DE DE19762654797 patent/DE2654797A1/de not_active Withdrawn
-
1977
- 1977-11-15 CH CH1393277A patent/CH609341A5/xx not_active IP Right Cessation
- 1977-11-28 NL NL7713083A patent/NL7713083A/xx not_active Application Discontinuation
- 1977-11-28 ES ES464533A patent/ES464533A2/es not_active Expired
- 1977-12-01 LU LU78614A patent/LU78614A1/xx unknown
- 1977-12-01 IT IT3028677A patent/IT1089430B/it active
- 1977-12-02 FR FR7736424A patent/FR2381756A2/fr active Granted
- 1977-12-02 IE IE245377A patent/IE46001B1/en unknown
- 1977-12-02 AT AT866177A patent/AT361917B/de not_active IP Right Cessation
- 1977-12-02 DK DK538777A patent/DK538777A/da not_active Application Discontinuation
- 1977-12-02 CA CA292,253A patent/CA1095056A/en not_active Expired
- 1977-12-02 GB GB5034277A patent/GB1572309A/en not_active Expired
- 1977-12-03 JP JP14561977A patent/JPS5371068A/ja active Pending
- 1977-12-05 BE BE183167A patent/BE861500R/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA866177A (de) | 1980-09-15 |
| FR2381756A2 (fr) | 1978-09-22 |
| LU78614A1 (es) | 1978-07-14 |
| IE46001L (en) | 1978-06-03 |
| GB1572309A (en) | 1980-07-30 |
| AT361917B (de) | 1981-04-10 |
| JPS5371068A (en) | 1978-06-24 |
| FR2381756B2 (es) | 1982-10-29 |
| IE46001B1 (en) | 1983-01-26 |
| NL7713083A (nl) | 1978-06-06 |
| DE2654797A1 (de) | 1978-06-08 |
| IT1089430B (it) | 1985-06-18 |
| CH609341A5 (en) | 1979-02-28 |
| DK538777A (da) | 1978-06-04 |
| BE861500R (fr) | 1978-06-05 |
| CA1095056A (en) | 1981-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20100616 |