ES460696A1 - Procedure for the obtaining of 2-piperidine alkyl- (1-benzofuranos-o-1,4-benzodioxanos). (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining 2-piperidinoalkyl- (1-benzofurans or 1,4-benzodioxanes) of general formula I **(See formula)** where Ph means a 1,2-phenylene residue, which is optionally substituted by 1 to 3 same or different substituents, selected from lower alkyl, hydroxy, mercapto, lower alkoxy, lower alkylenedioxy, benzyloxy, lower alkylthio, halogen, trifluoromethyl, nitro or amino, X means oxygen or sulfur, m is the integer 0 or 1 and n is 1 to 4, each of the symbols p and q represent an integer from 1 to 3, where (p + q) is the number 4, each of the symbols R1 and R2 means hydrogen, lower alkyl or HPh, R3 means hydrogen, hydroxy, lower alkoxy, lower or higher alkanoyloxy, R4 signifies lower alkyl, HPh-lower alkyl, HPh or naphthyl, which may be substituted as Ph, furyl, thienyl, pyridyl, benzofuryl, benzothienyl, quinolyl or isoquinolyl, the heterocyclic moieties of which are optionally substituted as Ph, as well as the acid addition salts, especially the therapeutically usable acid addition salts is one of these compounds, characterized in that a compound of formula III **(See formula)** where Y means an esterified hydroxy group, capable of reaction, the ring is closed and, if desired, a free compound obtained is transformed into an acid addition salt or an acid addition salt obtained in the free compound or in another acid addition salt, and/or, if desired, a mixture of isomers or racemates obtained is separated into the different isomers or racemates, and/or, if desired, the racemates obtained are dissociated at the optical antipodes. (Machine-translation by Google Translate, not legally binding)