ES439690A1 - Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES439690A1
ES439690A1 ES439690A ES439690A ES439690A1 ES 439690 A1 ES439690 A1 ES 439690A1 ES 439690 A ES439690 A ES 439690A ES 439690 A ES439690 A ES 439690A ES 439690 A1 ES439690 A1 ES 439690A1
Authority
ES
Spain
Prior art keywords
group
formula
see formula
aryl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES439690A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES439690A1 publication Critical patent/ES439690A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing quinazoline derivatives, of formula: **(See formula)** wherein (i) R1 is a hydrogen atom or a lower alkyl group; (R2) n represents 1 to 3 optional substituents, each R being a hydrogen atom or a lower hydroxy or alkoxy group and a being 1 to 3, or any two of the B2 moieties constituting a methylenedioxy or ethylenedioxy group attached to positions adjacent to ring A; (ii) X represents -CH2) p where p is 1 to 3, -CH = CH- or -0CH2 CH = CH (iii) Y is attached to position 3 or 4 of ring C and represents: (a) a group of formula -Z1-COR3, where Z1 is -CH2-or (see formula), R3 is a lower alkyl group optionally substituted by an amino, hydroxy, lower alkoxy, aryl or heteroaryl group; a lower alkenyl- or lower alkynyl-methyl group; a lower alkoxy group optionally substituted by an amino, aryl, heteroaryl, lower alkoxy or hydroxy group; an aryl group; an aryloxy group; or a heteroaryl group; and R4 is a hydrogen atom; a lower alkyl group optionally substituted by an amino, lower alkoxy, hydroxy, carbotoxy, aryl or heteroaryl group; a lower alkenyl- or lower alkynyl-methyl group; an aryl group or a heteroaryl group; (b) a group of the formula: **(See formula)** wherein R5 is a group or as defined above for R3 or is a group of formula: **(See formula)** wherein R7 is a hydrogen atom or a lower alkyl group and R6 is a group as defined above for R4, or R6 and R7 taken together with the nitrogen atom to which they are attached form a saturated monocyclic heterocyclic ring; or (c) a group of the formula: **(See formula)** wherein Z2 is Z1 or -O- and R6 and R7 are defined or as above, provided that when Z2 is (see formula), R4 and R7 taken together may represent - (CH2) 2-, - (CH2) 3 - or an o-phenylene group; and (iv) R is a hydrogen atom or a lower alkyl group attached to the same carbon atom as Y; provided that when Z is -CH = CH- or -CHsCH = GH-, R is absent and Y is -CH2COR3, -CH2CON (R6) (R7) or -CH2CSN (R6) (R7) where R3, R6 and R7 are defined or as above, Y being attached to an unsaturated ring carbon atom; characterized in that it comprises reacting a quinazoline of the formula: **(See formula)** where R1, R2 and n are defined as above and Q1 is a good leaving group, such as chlorine or bromine, with an amine of formula: **(See formula)** wherein X, Y and E are defined as above, any R2 and Y groups being protected or capable of displacing the leaving group Q1, prior to the reaction and deprotected after the reaction; and then recovering the resulting compound of formula (I). (Machine-translation by Google Translate, not legally binding)
ES439690A 1974-07-25 1975-07-24 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES439690A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3280574 1974-07-25

Publications (1)

Publication Number Publication Date
ES439690A1 true ES439690A1 (en) 1977-07-01

Family

ID=10344259

Family Applications (4)

Application Number Title Priority Date Filing Date
ES439690A Expired ES439690A1 (en) 1974-07-25 1975-07-24 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)
ES455984A Expired ES455984A1 (en) 1974-07-25 1977-02-16 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)
ES455985A Expired ES455985A1 (en) 1974-07-25 1977-02-16 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)
ES455986A Expired ES455986A1 (en) 1974-07-25 1977-02-16 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES455984A Expired ES455984A1 (en) 1974-07-25 1977-02-16 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)
ES455985A Expired ES455985A1 (en) 1974-07-25 1977-02-16 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)
ES455986A Expired ES455986A1 (en) 1974-07-25 1977-02-16 Procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
AT (1) AT344178B (en)
BE (1) BE831654A (en)
CS (1) CS192549B2 (en)
ES (4) ES439690A1 (en)
HU (1) HU174961B (en)
PL (6) PL103798B1 (en)
SU (5) SU578874A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070004763A1 (en) * 2005-06-10 2007-01-04 Nand Baindur Aminoquinoline and aminoquinazoline kinase modulators

Also Published As

Publication number Publication date
PL193422A1 (en) 1978-06-05
ES455985A1 (en) 1978-06-16
ES455984A1 (en) 1978-06-01
SU634671A3 (en) 1978-11-25
PL104615B1 (en) 1979-08-31
BE831654A (en) 1976-01-23
SU625606A3 (en) 1978-09-25
PL103789B1 (en) 1979-07-31
PL193423A1 (en) 1978-04-24
PL103797B1 (en) 1979-07-31
HU174961B (en) 1980-04-28
CS192549B2 (en) 1979-08-31
PL193420A1 (en) 1978-04-24
PL103791B1 (en) 1979-07-31
PL103798B1 (en) 1979-07-31
AT344178B (en) 1978-07-10
ATA525275A (en) 1977-11-15
ES455986A1 (en) 1978-06-01
PL99427B1 (en) 1978-07-31
PL193421A1 (en) 1978-04-24
SU858563A3 (en) 1981-08-23
PL193419A1 (en) 1978-04-24
SU578874A3 (en) 1977-10-30
SU613723A3 (en) 1978-06-30

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