ES459791A1 - Procedimiento para la preparacion de derivados 1-n-susti- tuidos de aminociclitoles. - Google Patents

Procedimiento para la preparacion de derivados 1-n-susti- tuidos de aminociclitoles.

Info

Publication number
ES459791A1
ES459791A1 ES459791A ES459791A ES459791A1 ES 459791 A1 ES459791 A1 ES 459791A1 ES 459791 A ES459791 A ES 459791A ES 459791 A ES459791 A ES 459791A ES 459791 A1 ES459791 A1 ES 459791A1
Authority
ES
Spain
Prior art keywords
aminoglycosides
transition metal
gentamicin
metal salts
intermediates used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459791A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of ES459791A1 publication Critical patent/ES459791A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedimiento para la preparación de derivados 1-N-sustituidos de aminociclitoles, específicamente de los 4,6-di-0-(aminoglicosil)-1,3-diaminociclitoles sisomicina, verdamicina, tobramicina, gentamicina C1, gentamicina Cla, gentamicina C2, gentamicina C2a, gentamicina C25 antibiótico 66-40B, antibiótico 66-40D, antibiótico JI-20A, antibiótico G-52, de los análogos 5-epi- y 5-epi-azido-5-ddesoxi de los anteriores;
ES459791A 1976-06-17 1977-06-15 Procedimiento para la preparacion de derivados 1-n-susti- tuidos de aminociclitoles. Expired ES459791A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/697,297 US4136254A (en) 1976-06-17 1976-06-17 Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby

Publications (1)

Publication Number Publication Date
ES459791A1 true ES459791A1 (es) 1978-08-16

Family

ID=24800569

Family Applications (1)

Application Number Title Priority Date Filing Date
ES459791A Expired ES459791A1 (es) 1976-06-17 1977-06-15 Procedimiento para la preparacion de derivados 1-n-susti- tuidos de aminociclitoles.

Country Status (18)

Country Link
US (1) US4136254A (es)
JP (5) JPS52153944A (es)
AR (1) AR216648A1 (es)
BE (1) BE855704A (es)
CA (1) CA1265130A (es)
CH (1) CH639979A5 (es)
DE (3) DE2759974C2 (es)
DK (1) DK165451C (es)
ES (1) ES459791A1 (es)
FR (2) FR2374331A1 (es)
GB (1) GB1575982A (es)
HK (1) HK484A (es)
HU (1) HU182050B (es)
IE (1) IE45734B1 (es)
IL (1) IL52318A (es)
MY (1) MY8500081A (es)
NL (1) NL177014C (es)
SE (2) SE447481B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
US4226980A (en) * 1978-12-07 1980-10-07 Abbott Laboratories Novel derivatives of fortimicin B and process for preparing same
JPS5723281A (en) * 1980-07-17 1982-02-06 Mitsubishi Electric Corp Semiconductor light-receiving element
US4424345A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4424344A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
EP0054514A1 (de) * 1980-12-16 1982-06-23 Ciba-Geigy Ag Neue antibiotisch wirksame Aminopapulacandin-Derivate
JPS6253997A (ja) * 1985-09-03 1987-03-09 Kowa Co 新規なアミノ配糖体及びこれを含有する製剤
JPS6281784A (ja) * 1985-10-04 1987-04-15 Nippon Telegr & Teleph Corp <Ntt> 半導体レ−ザの発光強度監視方法および半導体レ−ザ装置
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
US5442047A (en) * 1991-12-04 1995-08-15 Schering Corporation Process for preparing isepamicin
ATE152094T1 (de) * 1989-06-21 1997-05-15 Schering Corp N-geschützte (s)-isoserin-verbindungen
IT1237490B (it) * 1989-09-22 1993-06-07 Chementecno S R L Monza Milano Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
CN1040177C (zh) * 1993-04-23 1998-10-14 江苏省微生物研究所 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法
KR100467506B1 (ko) * 2002-10-01 2005-01-24 경동제약 주식회사 이세파마이신의 제조방법
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
AU2008326297B2 (en) * 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010037179A1 (en) 2008-10-03 2010-04-08 Glycan Biosciences Pty Ltd Anionic conjugates of glycosylated bacterial metabolite
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388141A (en) * 1965-10-05 1968-06-11 Thiokol Chemical Corp Di-schiff bases of hydroxyl substituted diamines and beta-diketones, derivatives, and metal chelates thereof
FR2015139A1 (es) * 1968-08-06 1970-04-24 Sanyo Chemical Cy Ltd
DE2061537A1 (de) * 1969-12-30 1971-07-08 Snam Progetti S.P.A., Mailand (Italien) Verfahren zur Herstellung von Kobalt(III>Komplexen
US3682995A (en) * 1970-05-04 1972-08-08 Minnesota Mining & Mfg Copper chelate
JPS5220991B2 (es) * 1972-08-23 1977-06-07
US4001208A (en) 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
GB1441202A (en) * 1973-05-15 1976-06-30 Microbial Chem Res Found 1-n-isoserylkanamycins and the production thereof
US3872080A (en) * 1973-06-26 1975-03-18 Schering Corp Process for the preparation of garamine and intermediates produced thereby
US3878193A (en) * 1973-06-26 1975-04-15 Schering Corp Process for the preparation of garamine derivatives
JPS5512039B2 (es) * 1974-03-22 1980-03-29
JPS573679B2 (es) 1974-03-07 1982-01-22
AR207582A1 (es) * 1974-03-19 1976-10-15 Scherico Ltd Procedimiento para preparar derivados de diaminociclitole
JPS5564598A (en) * 1978-11-11 1980-05-15 Microbial Chem Res Found Preparation of aminoglycoside antibiotic having selectively protected amino group

Also Published As

Publication number Publication date
IL52318A0 (en) 1977-08-31
DE2726712C2 (es) 1987-06-19
SE7706872L (sv) 1978-02-06
DE2726712A1 (de) 1977-12-22
CA1265130A (en) 1990-01-30
IE45734B1 (en) 1982-11-17
NL7706596A (nl) 1977-12-20
JPS5549586B2 (es) 1980-12-12
SE447481B (sv) 1986-11-17
IE45734L (en) 1977-12-17
JPS5569519A (en) 1980-05-26
DE2760317C2 (es) 1987-11-26
BE855704A (fr) 1977-12-15
FR2395277A1 (fr) 1979-01-19
MY8500081A (en) 1985-12-31
HU182050B (en) 1983-12-28
HK484A (en) 1984-01-13
NL177014C (nl) 1985-07-16
JPS5569598A (en) 1980-05-26
NL177014B (nl) 1985-02-18
JPS6127997A (ja) 1986-02-07
AR216648A1 (es) 1980-01-15
DE2759974C2 (es) 1988-05-26
JPS52153944A (en) 1977-12-21
FR2395277B1 (es) 1981-11-20
SE8601074D0 (sv) 1986-03-07
JPS6121558B2 (es) 1986-05-27
SE469131B (sv) 1993-05-17
IL52318A (en) 1981-06-29
DK263277A (da) 1977-12-18
US4136254A (en) 1979-01-23
FR2374331B1 (es) 1981-07-31
GB1575982A (en) 1980-10-01
JPS5822160B2 (ja) 1983-05-06
CH639979A5 (de) 1983-12-15
JPS6227073B2 (es) 1987-06-12
FR2374331A1 (fr) 1978-07-13
DK165451C (da) 1993-04-13
JPS5576895A (en) 1980-06-10
DK165451B (da) 1992-11-30
JPH0132232B2 (es) 1989-06-29

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