ES455620A1 - Un metodo para preparar una 2'-(carboximetoxi)-calcona. - Google Patents
Un metodo para preparar una 2'-(carboximetoxi)-calcona.Info
- Publication number
- ES455620A1 ES455620A1 ES455620A ES455620A ES455620A1 ES 455620 A1 ES455620 A1 ES 455620A1 ES 455620 A ES455620 A ES 455620A ES 455620 A ES455620 A ES 455620A ES 455620 A1 ES455620 A1 ES 455620A1
- Authority
- ES
- Spain
- Prior art keywords
- chalcones
- carboxymethoxy
- antigastric
- butenyloxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZZOYZTSGWGDKEX-UHFFFAOYSA-N 2-[2-(3-oxo-3-phenylprop-1-enyl)phenoxy]acetic acid Chemical class OC(=O)COC1=CC=CC=C1C=CC(=O)C1=CC=CC=C1 ZZOYZTSGWGDKEX-UHFFFAOYSA-N 0.000 title 1
- LJAXJWSGQODKEC-UHFFFAOYSA-N 2-[2-(3-phenylprop-2-enoyl)phenoxy]acetic acid Chemical class OC(=O)COC1=CC=CC=C1C(=O)C=CC1=CC=CC=C1 LJAXJWSGQODKEC-UHFFFAOYSA-N 0.000 abstract 1
- -1 3-methyl-2-butenyloxy Chemical group 0.000 abstract 1
- 230000007059 acute toxicity Effects 0.000 abstract 1
- 231100000403 acute toxicity Toxicity 0.000 abstract 1
- 230000007665 chronic toxicity Effects 0.000 abstract 1
- 231100000160 chronic toxicity Toxicity 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Abstract
Método para preparar nuevas 2'' (Carboximetoxi)-calconas antiulceras gástricas y duodenal. Mas particularmente, el invento se refiere a un método para preparar una 2''carboximetoxi)-calcona nueva de la formula (**formula**) en la que uno o dos de X1, X2, y X3 son 3-metil-2-buteniloxi, y los otros son hidrógeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1457876A JPS5297950A (en) | 1976-02-13 | 1976-02-13 | Chalconeether derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES455620A1 true ES455620A1 (es) | 1978-01-01 |
Family
ID=11865033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES455620A Expired ES455620A1 (es) | 1976-02-13 | 1977-02-03 | Un metodo para preparar una 2'-(carboximetoxi)-calcona. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4085135A (es) |
JP (1) | JPS5297950A (es) |
AR (1) | AR209544A1 (es) |
CA (1) | CA1084064A (es) |
CH (1) | CH605537A5 (es) |
DE (1) | DE2705603C2 (es) |
ES (1) | ES455620A1 (es) |
FR (1) | FR2340924A1 (es) |
GB (1) | GB1523241A (es) |
HU (1) | HU173019B (es) |
PT (1) | PT66118B (es) |
YU (1) | YU39378B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190671A (en) * | 1977-03-17 | 1980-02-26 | Biorex Laboratories Limited | Chalcone derivatives |
JPS5552597U (es) * | 1978-09-30 | 1980-04-08 | ||
JPS62207212A (ja) * | 1986-03-08 | 1987-09-11 | Nippon Haipotsukusu:Kk | 抗アレルギ−剤 |
US5089654A (en) * | 1989-08-08 | 1992-02-18 | Taisho Pharmaceutical Co., Ltd. | Chalcone derivatives |
JP2001509480A (ja) | 1997-07-09 | 2001-07-24 | アンドロソリューションズ,インク. | 男性勃起機能不全を治療するための改良された方法及び組成物 |
US6103765A (en) * | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
WO2001098291A2 (en) * | 2000-06-20 | 2001-12-27 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat vcam-1 mediated disorders |
EP1343502A2 (en) | 2000-11-17 | 2003-09-17 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
CN1596240A (zh) * | 2001-12-19 | 2005-03-16 | 阿特罗吉尼克斯公司 | 查耳酮衍生物及其治疗疾病的用途 |
AU2003303239A1 (en) * | 2002-12-19 | 2004-07-14 | Atherogenics, Inc. | Process of making chalcone derivatives |
WO2004108094A2 (en) * | 2003-06-06 | 2004-12-16 | Atherogenics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
WO2006004903A2 (en) * | 2004-06-28 | 2006-01-12 | Atherogenics, Inc. | 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
GB2471619B (en) * | 2008-03-31 | 2012-10-31 | Council Scient Ind Res | Method for the simultaneous preparation of 3-acetoxy-17-acetamdo-16-formyl-androst-5,16-diene and 3-acetoxy-2'-chloro-5-androsteno[17,6-B]pyridine |
CN101792385B (zh) * | 2009-12-10 | 2013-05-15 | 天津药物研究院 | 索法酮的晶型ⅷ及其制备方法和用途 |
CN101781194B (zh) * | 2009-12-10 | 2013-05-15 | 天津药物研究院 | 索法酮的晶型ⅴ及其制备方法和用途 |
CN101817741B (zh) * | 2009-12-10 | 2013-10-16 | 天津药物研究院 | 索法酮的晶型ⅸ及其制备方法和用途 |
CN101735038B (zh) * | 2009-12-10 | 2013-06-26 | 天津药物研究院 | 索法酮的晶型ⅰ及其制备方法和用途 |
CN101781195B (zh) * | 2009-12-10 | 2013-03-13 | 天津药物研究院 | 索法酮的晶型ⅶ及其制备方法和用途 |
CN101735040B (zh) * | 2009-12-10 | 2013-05-15 | 天津药物研究院 | 索法酮的晶型ⅲ及其制备方法和用途 |
CN101817742B (zh) * | 2009-12-10 | 2013-10-16 | 天津药物研究院 | 索法酮的晶型ⅹ及其制备方法和用途 |
CN101735039B (zh) * | 2009-12-10 | 2013-06-26 | 天津药物研究院 | 索法酮的晶型ⅱ及其制备方法和用途 |
CN101781192B (zh) * | 2009-12-10 | 2013-05-15 | 天津药物研究院 | 索法酮的晶型ⅵ及其制备方法和用途 |
CN101781193B (zh) * | 2009-12-10 | 2013-05-15 | 天津药物研究院 | 索法酮的晶型ⅳ及其制备方法和用途 |
CN115368265B (zh) * | 2022-10-24 | 2023-03-28 | 中国中医科学院中药研究所 | 一种索法酮小分子活性探针及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3255241A (en) * | 1961-01-19 | 1966-06-07 | Merck & Co Inc | (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids |
CH593224A5 (es) * | 1973-10-30 | 1977-11-30 | Taisho Pharmaceutical Co Ltd |
-
1976
- 1976-02-13 JP JP1457876A patent/JPS5297950A/ja active Granted
-
1977
- 1977-01-10 AR AR266135A patent/AR209544A1/es active
- 1977-01-14 YU YU89/77A patent/YU39378B/xx unknown
- 1977-01-26 FR FR7702191A patent/FR2340924A1/fr active Granted
- 1977-01-26 GB GB3220/77A patent/GB1523241A/en not_active Expired
- 1977-01-27 PT PT66118A patent/PT66118B/pt unknown
- 1977-02-03 ES ES455620A patent/ES455620A1/es not_active Expired
- 1977-02-04 CA CA271,121A patent/CA1084064A/en not_active Expired
- 1977-02-09 CH CH155477A patent/CH605537A5/xx not_active IP Right Cessation
- 1977-02-10 DE DE2705603A patent/DE2705603C2/de not_active Expired
- 1977-02-10 HU HU77TA00001427A patent/HU173019B/hu not_active IP Right Cessation
- 1977-02-11 US US05/767,974 patent/US4085135A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT66118B (en) | 1978-06-28 |
HU173019B (hu) | 1979-01-28 |
AU2131077A (en) | 1978-01-26 |
CH605537A5 (es) | 1978-09-29 |
AR209544A1 (es) | 1977-04-29 |
US4085135A (en) | 1978-04-18 |
FR2340924B1 (es) | 1979-03-23 |
YU39378B (en) | 1984-12-31 |
JPS5645896B2 (es) | 1981-10-29 |
CA1084064A (en) | 1980-08-19 |
PT66118A (en) | 1977-02-01 |
YU8977A (en) | 1982-06-30 |
FR2340924A1 (fr) | 1977-09-09 |
GB1523241A (en) | 1978-08-31 |
DE2705603C2 (de) | 1986-07-24 |
JPS5297950A (en) | 1977-08-17 |
DE2705603A1 (de) | 1977-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19981103 |