ES454073A1 - Procedimiento para la preparacion de acidos y esteres ariloxialquilaminobenzoicos. - Google Patents

Procedimiento para la preparacion de acidos y esteres ariloxialquilaminobenzoicos.

Info

Publication number
ES454073A1
ES454073A1 ES454073A ES454073A ES454073A1 ES 454073 A1 ES454073 A1 ES 454073A1 ES 454073 A ES454073 A ES 454073A ES 454073 A ES454073 A ES 454073A ES 454073 A1 ES454073 A1 ES 454073A1
Authority
ES
Spain
Prior art keywords
esters
acids
phenyl
naphthyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES454073A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES454073A1 publication Critical patent/ES454073A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Procedimiento para la preparación de ácidos y ésteres ariloxialquilaminobenzócios, de fórmula **(Fórmula)** en donde Y es alquilo de cadena recta o ramificada, CnH2n en donde n es 2 a 12; R1 es hidrógeno, alquilo inferior, 0 2, 3-dihidroxipropilo; X es fenilo, naftilo, tienilo, furilo, 1,2,3,4-tetrahidronaftilo, 4-cloro-1-naftilo, o fenilo substituido, en donde los substituyentes del fenilo son halógeno, hidroxilo, alcoxilo inferior, aralquilo inferior, ciano, trihalometilo, amino, alcanoilamino inferior, alquilamino inferior, dialquilamino inferior, fenoxi, p-clorofenoxi, bencilo-p-clorobenciloxi o cicloalquilo; y cuando R1 es hidrógeno, las sales de metales alcalinos o bases orgánicos del mismo; caracterizado porque comprende hacer reaccionar un p-aminobenzoato de alquilo inferior, ácido p-aminobenzoico, u otro éster de ácido p-aminobenzoico con un agente alquilante, con o sin un solvente, entre 50º a 170ºC durante 1 a 25 horas.
ES454073A 1975-12-09 1976-12-09 Procedimiento para la preparacion de acidos y esteres ariloxialquilaminobenzoicos. Expired ES454073A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63901875A 1975-12-09 1975-12-09

Publications (1)

Publication Number Publication Date
ES454073A1 true ES454073A1 (es) 1978-02-16

Family

ID=24562393

Family Applications (1)

Application Number Title Priority Date Filing Date
ES454073A Expired ES454073A1 (es) 1975-12-09 1976-12-09 Procedimiento para la preparacion de acidos y esteres ariloxialquilaminobenzoicos.

Country Status (22)

Country Link
JP (1) JPS5273834A (es)
AR (1) AR214187A1 (es)
AT (1) AT358013B (es)
AU (1) AU507077B2 (es)
BE (1) BE849231A (es)
BG (1) BG27540A3 (es)
CS (1) CS199283B2 (es)
DD (1) DD128354A5 (es)
DE (1) DE2654646A1 (es)
DK (1) DK550676A (es)
ES (1) ES454073A1 (es)
FR (1) FR2334347A1 (es)
GB (1) GB1533647A (es)
IL (1) IL50926A (es)
IN (1) IN145203B (es)
NL (1) NL7613696A (es)
PL (1) PL109985B1 (es)
PT (1) PT65945B (es)
RO (1) RO71276A (es)
SE (1) SE7613808L (es)
SU (1) SU636225A1 (es)
ZA (1) ZA766847B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207855D0 (en) * 1992-04-09 1992-05-27 Ici Plc Therapeutic amines
US5741926A (en) * 1997-02-12 1998-04-21 Shaman Pharmaceuticals, Inc. Aniline derivatives having antihyperglycemic activity

Also Published As

Publication number Publication date
FR2334347B1 (es) 1980-10-31
SE7613808L (sv) 1977-06-10
PT65945B (en) 1978-06-14
AU1983176A (en) 1978-05-25
CS199283B2 (en) 1980-07-31
RO71276A (ro) 1982-10-26
SU636225A1 (ru) 1978-12-05
IL50926A (en) 1980-12-31
PL109985B1 (en) 1980-06-30
IN145203B (es) 1978-09-09
DD128354A5 (de) 1977-11-16
ZA766847B (en) 1977-10-26
AU507077B2 (en) 1980-01-31
BE849231A (fr) 1977-06-09
PL194269A1 (pl) 1978-06-05
PT65945A (en) 1977-01-01
BG27540A3 (en) 1979-11-12
FR2334347A1 (fr) 1977-07-08
AT358013B (de) 1980-08-11
IL50926A0 (en) 1977-01-31
GB1533647A (en) 1978-11-29
AR214187A1 (es) 1979-05-15
DE2654646A1 (de) 1977-06-16
DK550676A (da) 1977-06-10
NL7613696A (nl) 1977-06-13
ATA907776A (de) 1980-01-15
JPS5273834A (en) 1977-06-21

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