ES448220A1 - Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona. - Google Patents
Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona.Info
- Publication number
- ES448220A1 ES448220A1 ES448220A ES448220A ES448220A1 ES 448220 A1 ES448220 A1 ES 448220A1 ES 448220 A ES448220 A ES 448220A ES 448220 A ES448220 A ES 448220A ES 448220 A1 ES448220 A1 ES 448220A1
- Authority
- ES
- Spain
- Prior art keywords
- flunisolide
- respiratory diseases
- treat respiratory
- compound
- polymorphic form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960000676 flunisolide Drugs 0.000 title 2
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 title 2
- 208000023504 respiratory system disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58130175A | 1975-05-27 | 1975-05-27 | |
| US58130075A | 1975-05-27 | 1975-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES448220A1 true ES448220A1 (es) | 1977-11-01 |
Family
ID=27078279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES448220A Expired ES448220A1 (es) | 1975-05-27 | 1976-05-25 | Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona. |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS51144719A (OSRAM) |
| AT (1) | AT357702B (OSRAM) |
| AU (1) | AU506080B2 (OSRAM) |
| CA (1) | CA1075228A (OSRAM) |
| DE (2) | DE2624924C2 (OSRAM) |
| ES (1) | ES448220A1 (OSRAM) |
| FR (1) | FR2361900A1 (OSRAM) |
| GB (1) | GB1525181A (OSRAM) |
| HK (1) | HK8580A (OSRAM) |
| IL (1) | IL49652A (OSRAM) |
| MX (1) | MX3864E (OSRAM) |
| MY (1) | MY8000275A (OSRAM) |
| NL (1) | NL191234C (OSRAM) |
| NZ (1) | NZ180946A (OSRAM) |
| SE (1) | SE421426B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189201C (nl) * | 1979-05-21 | 1993-02-01 | Syntex Corp | Werkwijze voor de bereiding van een kristallijne vorm van flunisolide. |
| ATE3774T1 (de) * | 1980-05-02 | 1983-06-15 | Schering Corporation | Beclomethason-ester-solvate, verfahren zu ihrer herstellung und herstellung einer formulierung. |
| GB2127689B (en) * | 1982-10-05 | 1986-07-09 | Sandoz Ltd | Calcitonin inhalation compositions |
| US4782047A (en) * | 1986-05-22 | 1988-11-01 | Syntex Pharmaceuticals International Ltd. | Aqueous steroid formulations for nasal administration |
| HU209603B (en) * | 1988-10-05 | 1994-09-28 | Upjohn Co | Process for production of solid powders in finalydivided microcristallin form |
| US5707634A (en) * | 1988-10-05 | 1998-01-13 | Pharmacia & Upjohn Company | Finely divided solid crystalline powders via precipitation into an anti-solvent |
| DE4003272A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
| PT835098E (pt) * | 1995-06-27 | 2002-12-31 | Boehringer Ingelheim Pharma | Nova composicao farmaceutica estavel para a producao de aerossois sem gas propulsante |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| BR0008650B1 (pt) * | 1999-03-03 | 2010-12-28 | dispositivo de transmissão via nasal. | |
| IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
| BR0015884A (pt) | 2000-05-22 | 2003-07-08 | Chiesi Farma Spa | Formulações de soluções farmacêuticas estáveis para inaladores de dose medida pressurizados |
| ATE267591T1 (de) | 2001-07-02 | 2004-06-15 | Chiesi Farma Spa | Optimierte tobramycin-formulierung zur aerosolbildung |
| JP5238779B2 (ja) * | 2003-04-25 | 2013-07-17 | ロート製薬株式会社 | 点鼻剤 |
| JP4632687B2 (ja) * | 2003-04-25 | 2011-02-16 | ロート製薬株式会社 | 点鼻剤 |
| EP1595531A1 (en) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
| AU2014233362A1 (en) * | 2013-03-15 | 2015-10-01 | Medicis Pharmaceutical Corporation | Topical compositions of flunisolide and methods of treatment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3126375A (en) * | 1964-03-24 | Chioacyl | ||
| GB933868A (en) * | 1958-12-08 | 1963-08-14 | American Cyanamid Co | Process for fluorinating steroids |
| US3282791A (en) * | 1965-08-17 | 1966-11-01 | Merck & Co Inc | Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate |
| US3592930A (en) | 1968-07-19 | 1971-07-13 | Syntex Corp | Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle |
| FR2038105A1 (fr) * | 1969-04-01 | 1971-01-08 | Syntex Corp | Composition anti-inflammatoire locale et son mode d'utilisation |
| GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| DE2332663C2 (de) * | 1973-06-23 | 1986-07-31 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verwendung von Kortikoid-Wirkstoffen zur Inhalationstherapie |
| US3934013A (en) | 1975-02-21 | 1976-01-20 | Syntex (U.S.A.) Inc. | Pharmaceutical composition |
-
1976
- 1976-05-14 MX MX76234U patent/MX3864E/es unknown
- 1976-05-25 IL IL49652A patent/IL49652A/xx unknown
- 1976-05-25 CA CA253,267A patent/CA1075228A/en not_active Expired
- 1976-05-25 ES ES448220A patent/ES448220A1/es not_active Expired
- 1976-05-25 NZ NZ180946A patent/NZ180946A/xx unknown
- 1976-05-25 SE SE7605927A patent/SE421426B/xx not_active IP Right Cessation
- 1976-05-26 AU AU14301/76A patent/AU506080B2/en not_active Expired
- 1976-05-26 GB GB21936/76A patent/GB1525181A/en not_active Expired
- 1976-05-26 NL NL7605699A patent/NL191234C/xx not_active IP Right Cessation
- 1976-05-26 AT AT388376A patent/AT357702B/de not_active IP Right Cessation
- 1976-05-26 FR FR7616040A patent/FR2361900A1/fr active Granted
- 1976-05-26 JP JP51061032A patent/JPS51144719A/ja active Granted
- 1976-06-03 DE DE2624924A patent/DE2624924C2/de not_active Expired
- 1976-06-03 DE DE2661037A patent/DE2661037C2/de not_active Expired
-
1980
- 1980-03-06 HK HK85/80A patent/HK8580A/xx unknown
- 1980-12-30 MY MY275/80A patent/MY8000275A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2624924C2 (de) | 1986-11-27 |
| GB1525181A (en) | 1978-09-20 |
| IL49652A0 (en) | 1976-07-30 |
| NL191234B (nl) | 1994-11-01 |
| HK8580A (en) | 1980-03-14 |
| DE2661037C2 (OSRAM) | 1989-04-06 |
| AU506080B2 (en) | 1979-12-13 |
| CA1075228A (en) | 1980-04-08 |
| AU1430176A (en) | 1977-12-01 |
| JPS6247880B2 (OSRAM) | 1987-10-09 |
| JPS51144719A (en) | 1976-12-13 |
| NL191234C (nl) | 1995-04-03 |
| NL7605699A (nl) | 1976-11-30 |
| FR2361900B1 (OSRAM) | 1979-04-13 |
| SE7605927L (sv) | 1976-11-28 |
| ATA388376A (de) | 1979-12-15 |
| IL49652A (en) | 1979-05-31 |
| NZ180946A (en) | 1978-07-28 |
| MX3864E (es) | 1981-08-26 |
| SE421426B (sv) | 1981-12-21 |
| DE2624924A1 (de) | 1977-12-15 |
| MY8000275A (en) | 1980-12-31 |
| AT357702B (de) | 1980-07-25 |
| FR2361900A1 (fr) | 1978-03-17 |
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