ES447805A1 - Un procedimiento para la preparacion de esteres de 3-amino disustituidos-cefalosporina. - Google Patents

Un procedimiento para la preparacion de esteres de 3-amino disustituidos-cefalosporina.

Info

Publication number
ES447805A1
ES447805A1 ES447805A ES447805A ES447805A1 ES 447805 A1 ES447805 A1 ES 447805A1 ES 447805 A ES447805 A ES 447805A ES 447805 A ES447805 A ES 447805A ES 447805 A1 ES447805 A1 ES 447805A1
Authority
ES
Spain
Prior art keywords
cephem
esters
amino
ester
sulfonyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES447805A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES447805A1 publication Critical patent/ES447805A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Nuevo procedimiento para la preparación de nuevos ésteres de ácido 7-amino(o 7-acilamido)-3(amino disustituído)-3-cefem-4-carboxílico. Los 3-amino-sustituído-cefem-ésteres son intermediarios útiles que pueden ser reducidos con diborano a los correspondientes ésteres 3H-3-cefémicos o, alternativamente, pueden reaccionar con reactivos de Grignard, v.g. bromuro de fenilmagnesio para dar, por ejemplo, el éster 3-fenil-3-cefémico.
ES447805A 1975-05-12 1976-05-11 Un procedimiento para la preparacion de esteres de 3-amino disustituidos-cefalosporina. Expired ES447805A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/576,818 US4013651A (en) 1975-05-12 1975-05-12 3-substituted amino-cephalosporins

Publications (1)

Publication Number Publication Date
ES447805A1 true ES447805A1 (es) 1978-04-01

Family

ID=24306128

Family Applications (3)

Application Number Title Priority Date Filing Date
ES447806A Expired ES447806A1 (es) 1975-05-12 1976-05-11 Un procedimiento para la preparacion de esteres de 3h-cefem-cefalosporina.
ES447805A Expired ES447805A1 (es) 1975-05-12 1976-05-11 Un procedimiento para la preparacion de esteres de 3-amino disustituidos-cefalosporina.
ES447807A Expired ES447807A1 (es) 1975-05-12 1976-05-11 Un procedimiento para la preparacion de esteres de 3-cefema.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES447806A Expired ES447806A1 (es) 1975-05-12 1976-05-11 Un procedimiento para la preparacion de esteres de 3h-cefem-cefalosporina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES447807A Expired ES447807A1 (es) 1975-05-12 1976-05-11 Un procedimiento para la preparacion de esteres de 3-cefema.

Country Status (11)

Country Link
US (3) US4013651A (es)
JP (1) JPS51138697A (es)
BE (1) BE841496A (es)
CA (1) CA1074782A (es)
CH (3) CH623054A5 (es)
DE (1) DE2620308A1 (es)
ES (3) ES447806A1 (es)
GB (1) GB1544984A (es)
IE (1) IE42540B1 (es)
IL (1) IL49318A (es)
NL (3) NL7605078A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947413A (en) * 1972-11-13 1976-03-30 Merck & Co., Inc. 3-α-Substituted cephalosporins
US4550162A (en) * 1975-02-20 1985-10-29 Ciba-Geigy Corporation Process for the manufacture of enol derivatives
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
JPS543087A (en) * 1977-06-03 1979-01-11 Fujisawa Pharmaceut Co Ltd Preparation of cephalosporin compound
US4244885A (en) * 1977-12-08 1981-01-13 Yeda Research And Development Co. Ltd. α-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids
US4436903A (en) * 1980-12-22 1984-03-13 Ciba-Geigy Corporation Process for the production of 7 β-substituted-3-unsubstituted-3-cephem-4-carboxylic acid compounds
US4533497A (en) * 1982-12-27 1985-08-06 Eli Lilly And Company N-ethylidene azetidinones
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
JPH021487A (ja) * 1988-01-25 1990-01-05 Eli Lilly & Co １―カルバセファロスポリン抗生物質
WO2017190043A1 (en) * 2016-04-29 2017-11-02 University Of Kansas Cephalosporin-type compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE412238B (sv) * 1971-05-24 1980-02-25 Ciba Geigy Forfarande for framstellning av 7 beta-amino-cefem-4-karboxylsyraforeningar genom dekarbonylering av en 3-formyl-cefem-4-karboxylsyraforening
US4001226A (en) * 1974-12-04 1977-01-04 Eli Lilly And Company 3-(substituted)carbonylamino cephem derivatives
JPS609516B2 (ja) * 1975-03-07 1985-03-11 塩野義製薬株式会社 セフエム骨格の環化製法
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen

Also Published As

Publication number Publication date
JPS51138697A (en) 1976-11-30
NL7605075A (nl) 1976-11-16
GB1544984A (en) 1979-04-25
US4013651A (en) 1977-03-22
CH623054A5 (es) 1981-05-15
ES447806A1 (es) 1977-10-01
IE42540B1 (en) 1980-08-27
CA1074782A (en) 1980-04-01
IE42540L (en) 1976-11-12
NL7605078A (nl) 1976-11-16
US4065621A (en) 1977-12-27
DE2620308A1 (de) 1976-11-25
IL49318A (en) 1980-03-31
NL7605077A (nl) 1976-11-16
CH619958A5 (es) 1980-10-31
ES447807A1 (es) 1977-10-01
US4065618A (en) 1977-12-27
IL49318A0 (en) 1976-05-31
BE841496A (fr) 1976-11-08
CH621123A5 (es) 1981-01-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202