ES444634A2 - Procedure for the preparation of derivatives of isoindoline. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Improvements in the object of the main patent no. 396,473, by process for the preparation of isoindoline derivatives of the general formula (I) **(See formula)** in which R is a member chosen from the group consisting of hydrogen and lower alkyl of 1 to 4 carbon atoms, and R1 is a member chosen from the group consisting of hydrogen, lower alkyl with 1 to 4 carbon atoms and a group of the general formula (see formula) where n is 1 or 2 and R2 and R3 are independently chosen from the group consisting of hydrogen and lower alkyl of 1 to 4 carbon atoms, as well as the salts of the compounds of the general formula (I), wherein R1 is hydrogen, with pharmaceutically acceptable bases, and salts of the compound of the general formula (I), where R1 is a group (see formula) with pharmaceutically acceptable acids, characterized in that they comprise reacting phthalide, thiophthalide or phthalic aldehyde with a compound of formula (II) **(See formula)** in which R has the meaning indicated above and X1 is carboxyl, or reduce a compound of formula (III) **(See formula)** where R has the meaning antas indicated and x1 is carboxyl, thus obtaining compounds of the general formula (I), where R1 is hydrogen which, if desired, can be esterified to obtain compounds of the general formula (1), where R1 is lower alkyl of 1 to 4 carbon atoms or a group of the general formula (see formula), where n is 1 or 2 and R2 and R3 are independently selected, from the group consisting of hydrogen or lower alkyl of 1 to 4 carbon atoms, or salified with acids or bases acceptable in pharmacy. (Machine-translation by Google Translate, not legally binding)