ES442886A1 - D-6-methyl-2,8-disubstituted ergolines - Google Patents
D-6-methyl-2,8-disubstituted ergolinesInfo
- Publication number
- ES442886A1 ES442886A1 ES442886A ES442886A ES442886A1 ES 442886 A1 ES442886 A1 ES 442886A1 ES 442886 A ES442886 A ES 442886A ES 442886 A ES442886 A ES 442886A ES 442886 A1 ES442886 A1 ES 442886A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- ergoline
- substituted
- give
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of a new 2-substituted and 8-substituted D-6-methyl-ergoline of formula I: ** (See formula) ** where X is methyl and R is CH2-CN or (see formula) and its salts formed with pharmaceutically acceptable acids, whose process is characterized by formylating D-6-methyl-8-cyanomethyl-, or 8-carboxamidomethyl-ergoline in the presence of ethanedithiol to give the 2-formyl group dithiacetal and then desulfurizing the resulting dithioacetal to give the desired 2-methyl compound and then, if desired, forming the pharmaceutically acceptable acid salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27390272A | 1972-07-21 | 1972-07-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES442886A1 true ES442886A1 (en) | 1977-04-16 |
Family
ID=23045910
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417078A Expired ES417078A1 (en) | 1972-07-21 | 1973-07-20 | D-6-methyl-2,8-disubstituted ergolines |
| ES442887A Expired ES442887A1 (en) | 1972-07-21 | 1975-11-21 | D-6-methyl-2,8-disubstituted ergolines |
| ES442885A Expired ES442885A1 (en) | 1972-07-21 | 1975-11-21 | D-6-methyl-2,8-disubstituted ergolines |
| ES442886A Expired ES442886A1 (en) | 1972-07-21 | 1975-11-21 | D-6-methyl-2,8-disubstituted ergolines |
| ES446789A Expired ES446789A1 (en) | 1972-07-21 | 1976-04-07 | D-6-methyl-2,8-disubstituted ergolines |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417078A Expired ES417078A1 (en) | 1972-07-21 | 1973-07-20 | D-6-methyl-2,8-disubstituted ergolines |
| ES442887A Expired ES442887A1 (en) | 1972-07-21 | 1975-11-21 | D-6-methyl-2,8-disubstituted ergolines |
| ES442885A Expired ES442885A1 (en) | 1972-07-21 | 1975-11-21 | D-6-methyl-2,8-disubstituted ergolines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES446789A Expired ES446789A1 (en) | 1972-07-21 | 1976-04-07 | D-6-methyl-2,8-disubstituted ergolines |
Country Status (24)
| Country | Link |
|---|---|
| JP (2) | JPS576431B2 (en) |
| AR (3) | AR206772A1 (en) |
| AT (1) | AT331425B (en) |
| BE (1) | BE802531A (en) |
| BG (3) | BG21411A3 (en) |
| CA (1) | CA1006159A (en) |
| CH (5) | CH578563A5 (en) |
| CS (1) | CS208164B2 (en) |
| DD (1) | DD107690A5 (en) |
| DE (2) | DE2365974A1 (en) |
| DK (1) | DK140986B (en) |
| ES (5) | ES417078A1 (en) |
| FR (1) | FR2193606B1 (en) |
| GB (1) | GB1423065A (en) |
| HU (1) | HU167274B (en) |
| IE (1) | IE37936B1 (en) |
| IL (3) | IL42730A (en) |
| NL (1) | NL7309969A (en) |
| PH (1) | PH11229A (en) |
| RO (2) | RO63792A (en) |
| SE (3) | SE393111B (en) |
| SU (3) | SU645581A3 (en) |
| YU (1) | YU36953B (en) |
| ZA (1) | ZA734627B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1517973A (en) * | 1974-07-19 | 1978-07-19 | Sandoz Ltd | 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i |
| US3968111A (en) * | 1974-12-06 | 1976-07-06 | Eli Lilly And Company | 8,8-Disubstituted-6-methylergolines and related compounds |
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| AU526764B2 (en) * | 1978-09-08 | 1983-01-27 | Farmitalia Carlo Erba S.P.A. | Ergoline derivatives |
| ATE107647T1 (en) * | 1984-04-09 | 1994-07-15 | Schering Ag | 2-SUBSTITUTED ERGOLINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. |
| HU196598B (en) * | 1986-04-25 | 1988-12-28 | Richter Gedeon Vegyeszet | Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds |
| DE3620293A1 (en) * | 1986-06-16 | 1987-12-17 | Schering Ag | 1 AND / OR 2 SUBSTITUTED ERGOL DERIVATIVES |
| JPH0596382U (en) * | 1992-05-28 | 1993-12-27 | イビデン株式会社 | Door unit |
-
1973
- 1973-01-01 AR AR249167A patent/AR206772A1/en active
- 1973-07-10 GB GB3289073A patent/GB1423065A/en not_active Expired
- 1973-07-10 ZA ZA734627A patent/ZA734627B/en unknown
- 1973-07-12 SE SE7309781A patent/SE393111B/en unknown
- 1973-07-12 IL IL42730A patent/IL42730A/en unknown
- 1973-07-12 IL IL48288A patent/IL48288A/en unknown
- 1973-07-13 DE DE2365974A patent/DE2365974A1/en not_active Withdrawn
- 1973-07-13 DE DE2335750A patent/DE2335750C3/en not_active Expired
- 1973-07-17 NL NL7309969A patent/NL7309969A/xx not_active Application Discontinuation
- 1973-07-17 YU YU1945/73A patent/YU36953B/en unknown
- 1973-07-18 PH PH14835A patent/PH11229A/en unknown
- 1973-07-19 DK DK399873AA patent/DK140986B/en unknown
- 1973-07-19 BE BE1005246A patent/BE802531A/en not_active IP Right Cessation
- 1973-07-19 HU HUEI485A patent/HU167274B/hu unknown
- 1973-07-20 SU SU731948966A patent/SU645581A3/en active
- 1973-07-20 CA CA177,021A patent/CA1006159A/en not_active Expired
- 1973-07-20 RO RO7300083213A patent/RO63792A/en unknown
- 1973-07-20 CH CH391176A patent/CH578563A5/xx not_active IP Right Cessation
- 1973-07-20 CH CH391276A patent/CH580626A5/xx not_active IP Right Cessation
- 1973-07-20 FR FR7326708A patent/FR2193606B1/fr not_active Expired
- 1973-07-20 AT AT643473A patent/AT331425B/en not_active IP Right Cessation
- 1973-07-20 CS CS735239A patent/CS208164B2/en unknown
- 1973-07-20 BG BG26855A patent/BG21411A3/xx not_active Expired
- 1973-07-20 BG BG28443A patent/BG22400A3/xx unknown
- 1973-07-20 DD DD172402A patent/DD107690A5/xx unknown
- 1973-07-20 RO RO7375548A patent/RO71305A/en unknown
- 1973-07-20 BG BG24148A patent/BG21410A3/xx unknown
- 1973-07-20 JP JP8074973A patent/JPS576431B2/ja not_active Expired
- 1973-07-20 CH CH391076A patent/CH580625A5/xx not_active IP Right Cessation
- 1973-07-20 IE IE1238/73A patent/IE37936B1/en unknown
- 1973-07-20 CH CH391376A patent/CH578564A5/xx not_active IP Right Cessation
- 1973-07-20 ES ES417078A patent/ES417078A1/en not_active Expired
- 1973-07-20 CH CH1067873A patent/CH581135A5/xx not_active IP Right Cessation
-
1974
- 1974-01-01 AR AR252738A patent/AR206887A1/en active
- 1974-12-04 SU SU7402080295A patent/SU584780A3/en active
-
1975
- 1975-01-14 SU SU7502098198A patent/SU575029A3/en active
- 1975-01-30 AR AR257473A patent/AR210072A1/en active
- 1975-10-13 IL IL48288A patent/IL48288A0/en unknown
- 1975-11-21 ES ES442887A patent/ES442887A1/en not_active Expired
- 1975-11-21 ES ES442885A patent/ES442885A1/en not_active Expired
- 1975-11-21 ES ES442886A patent/ES442886A1/en not_active Expired
-
1976
- 1976-04-07 ES ES446789A patent/ES446789A1/en not_active Expired
- 1976-10-15 SE SE7611466A patent/SE410459B/en unknown
- 1976-10-15 SE SE7611467A patent/SE410603B/en unknown
-
1981
- 1981-08-07 JP JP56123937A patent/JPS5813541B2/en not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20100623 |