ES440760A1 - Procedimiento para preparar derivados de quinoxalina y qui- nazolina. - Google Patents
Procedimiento para preparar derivados de quinoxalina y qui- nazolina.Info
- Publication number
- ES440760A1 ES440760A1 ES440760A ES440760A ES440760A1 ES 440760 A1 ES440760 A1 ES 440760A1 ES 440760 A ES440760 A ES 440760A ES 440760 A ES440760 A ES 440760A ES 440760 A1 ES440760 A1 ES 440760A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- quinoxaline
- positions
- aminoethylthioureido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000002462 imidazolines Chemical class 0.000 title 1
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002540 isothiocyanates Chemical class 0.000 abstract 2
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- -1 β-aminoethylthioureido compound Chemical class 0.000 abstract 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3914374A GB1463520A (en) | 1974-09-06 | 1974-09-06 | Process for the production of imidazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES440760A1 true ES440760A1 (es) | 1977-04-01 |
Family
ID=10407882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440760A Expired ES440760A1 (es) | 1974-09-06 | 1975-09-05 | Procedimiento para preparar derivados de quinoxalina y qui- nazolina. |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS51149291A (nl) |
| BE (1) | BE833135A (nl) |
| CA (1) | CA1043791A (nl) |
| DE (1) | DE2538620A1 (nl) |
| DK (1) | DK398775A (nl) |
| ES (1) | ES440760A1 (nl) |
| FI (1) | FI752487A (nl) |
| FR (1) | FR2283899A1 (nl) |
| GB (1) | GB1463520A (nl) |
| LU (1) | LU73327A1 (nl) |
| NL (1) | NL7510473A (nl) |
| SE (1) | SE7509271L (nl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204347A (en) * | 1989-10-12 | 1993-04-20 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines |
| US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
| US5198442A (en) * | 1989-10-12 | 1993-03-30 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
| US5112822A (en) * | 1989-10-12 | 1992-05-12 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
| US5326763A (en) * | 1989-10-12 | 1994-07-05 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
| US5237072A (en) * | 1990-02-06 | 1993-08-17 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
| US5130441A (en) * | 1990-02-06 | 1992-07-14 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
| ES2187533T3 (es) * | 1993-10-13 | 2003-06-16 | Allergan Inc | Usdo de derivados de (2-imidazolin-2-ilamino)quinoxalina. |
| US6323204B1 (en) | 1993-10-13 | 2001-11-27 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| CA2505836C (en) | 2004-05-06 | 2013-08-27 | Alcon Inc. | Topical brimonidine tartrate formulations that lack chlorine dioxide |
| UA117768C2 (uk) | 2013-12-24 | 2018-09-25 | Сентісс Фарма Прайвет Лімітед | Офтальмологічний розчин тартрату бримонідину для місцевого застосування |
| JP6339364B2 (ja) * | 2013-12-27 | 2018-06-06 | カズマパートナーズ株式会社 | 無定形ブリモニジン酒石酸塩及びその製造方法 |
| JP6270603B2 (ja) * | 2014-04-14 | 2018-01-31 | カズマパートナーズ株式会社 | ブリモニジン酒石酸塩の新規多形及びその製造方法 |
| US20230218611A1 (en) | 2020-04-29 | 2023-07-13 | Sentiss Pharma Private Limited | Ophthalmic compositions comprising a combination of brinzolamide and brimonidine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
-
1974
- 1974-09-06 GB GB3914374A patent/GB1463520A/en not_active Expired
-
1975
- 1975-08-25 SE SE7509271A patent/SE7509271L/xx unknown
- 1975-08-27 CA CA234,270A patent/CA1043791A/en not_active Expired
- 1975-08-29 DE DE19752538620 patent/DE2538620A1/de active Pending
- 1975-09-01 JP JP50105862A patent/JPS51149291A/ja active Pending
- 1975-09-04 FI FI752487A patent/FI752487A/fi not_active Application Discontinuation
- 1975-09-04 LU LU73327A patent/LU73327A1/xx unknown
- 1975-09-05 DK DK398775A patent/DK398775A/da unknown
- 1975-09-05 BE BE159796A patent/BE833135A/xx unknown
- 1975-09-05 FR FR7527324A patent/FR2283899A1/fr not_active Withdrawn
- 1975-09-05 NL NL7510473A patent/NL7510473A/nl unknown
- 1975-09-05 ES ES440760A patent/ES440760A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2283899A1 (fr) | 1976-04-02 |
| FI752487A (nl) | 1976-03-07 |
| DE2538620A1 (de) | 1976-03-18 |
| DK398775A (da) | 1976-03-07 |
| AU8430575A (en) | 1977-03-03 |
| GB1463520A (en) | 1977-02-02 |
| JPS51149291A (en) | 1976-12-22 |
| NL7510473A (nl) | 1976-03-09 |
| BE833135A (fr) | 1976-03-05 |
| SE7509271L (sv) | 1975-12-29 |
| LU73327A1 (nl) | 1977-05-11 |
| CA1043791A (en) | 1978-12-05 |
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