ES2187533T3 - Usdo de derivados de (2-imidazolin-2-ilamino)quinoxalina. - Google Patents

Usdo de derivados de (2-imidazolin-2-ilamino)quinoxalina.

Info

Publication number
ES2187533T3
ES2187533T3 ES94928623T ES94928623T ES2187533T3 ES 2187533 T3 ES2187533 T3 ES 2187533T3 ES 94928623 T ES94928623 T ES 94928623T ES 94928623 T ES94928623 T ES 94928623T ES 2187533 T3 ES2187533 T3 ES 2187533T3
Authority
ES
Spain
Prior art keywords
sub
group
mammer
reduction
ilamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94928623T
Other languages
English (en)
Inventor
James A Burke
Michael E Garst
Larry A Wheeler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ES2187533T3 publication Critical patent/ES2187533T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

METODO PARA EL TRATAMIENTO DE UN MAMIFERO QUE COMPRENDE LA ADMINISTRACION A UN MAMIFERO DE UNA CANTIDAD EFECTIVA PARA PROPORCIONAR EL EFECTO TERAPEUTICO DESEADO EN EL MAMIFERO, DE UN COMPUESTO SELECCIONADO DEL GRUPO QUE SE COMPONE DE AQUELLOS QUE TIENEN LA FORMULA (I), Y SALES ACIDAS DE ADICION FARMACEUTICAMENTE ACEPTABLES DEL MISMO Y MEZCLAS DEL MISMO, EN DONDE R{SUB,1} Y R{SUB,2} SON SELECCIONADOS DEL GRUPO COMPUESTO POR RADICALES ALQUILO QUE CONTIENEN DE 1 A 4 ATOMOS DE CARBONO Y RADICALES ALCOXI QUE CONTIENEN DE 1 A 4 ATOMOS DE CARBONO, EL GRUPO 2-IMIDAZOLIN-2-ILAMINO PUEDE ESTAR EN CUALQUIERA DE LAS POSICIONES 5-,6-,7 U 8 DEL NUCLEO DE QUINOXALINA, Y R{SUB,3}, R{SUB,4} Y R{SUB,5}, CADA UNO DE ELLOS ESTA SITUADO EN LAS SITUACIONES RESTANTES 5-, 6-, 7-, U 8, DEL NUCLEO DE QUINOXALINA Y ES SELECCIONADO INDEPENDIENTEMENTE DEL GRUPO CONSISTENTE EN CL, BR, H Y RADICALES ALQUILO QUE CONTIENEN DE 1 A 3 ATOMOS DE CARBONO. DICHOS COMPUESTOS, CUANDO SE ADMINISTRAN A UN MAMIFERO, PROPORCIONAN LOSEFECTOS TERAPEUTICOS DESEADOS, COMO LA REDUCCION DEL DOLOR PERIFERICO, LA ANESTESIA DEL SISTEMA NERVIOSO CENTRAL, LA CONSTRICCION DE UNO O MAS VASOS SANGUINEOS, LA REDUCCION O PREVENCION DE AL MENOS UN EFECTO DE LA ISQUEMIA, DESCONGESTION DE UNO O MAS CONDUCTOS NASALES, REDUCCION DE AL MENOS UN EFECTO DE LAS ENFERMEDADES INFLAMATORIAS, AUMENTO DEL FLUJO RENAL FLUIDO, Y ALTERACION DEL INDICE DE FLUIDO EN EL TRACTO GASTROINTESTINAL.
ES94928623T 1993-10-13 1994-09-19 Usdo de derivados de (2-imidazolin-2-ilamino)quinoxalina. Expired - Lifetime ES2187533T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13571693A 1993-10-13 1993-10-13

Publications (1)

Publication Number Publication Date
ES2187533T3 true ES2187533T3 (es) 2003-06-16

Family

ID=22469328

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94928623T Expired - Lifetime ES2187533T3 (es) 1993-10-13 1994-09-19 Usdo de derivados de (2-imidazolin-2-ilamino)quinoxalina.

Country Status (8)

Country Link
US (7) US5552403A (es)
EP (2) EP1285657A3 (es)
JP (3) JP3683908B2 (es)
AU (1) AU688380B2 (es)
CA (1) CA2173974C (es)
DE (1) DE69431880T2 (es)
ES (1) ES2187533T3 (es)
WO (1) WO1995010280A1 (es)

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US6465713B1 (en) * 1997-06-30 2002-10-15 Mcneil-Ppc, Inc. Tampon having an apertured film cover
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US20030087962A1 (en) * 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
ATE291907T1 (de) * 1998-10-20 2005-04-15 Omeros Corp Spülende lösung und methoden zur hemmung von schmerzen und entzündungen
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US6242442B1 (en) 1998-12-17 2001-06-05 Alcon Laboratories, Inc. Brinzolamide and brimonidine for treating ocular conditions
US6294553B1 (en) * 2000-02-15 2001-09-25 Allergan Sales, Inc. Method for treating ocular pain
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Also Published As

Publication number Publication date
EP0723447A1 (en) 1996-07-31
US5703077A (en) 1997-12-30
US5756503A (en) 1998-05-26
EP0723447B1 (en) 2002-12-11
US5587376A (en) 1996-12-24
EP1285657A2 (en) 2003-02-26
WO1995010280A1 (en) 1995-04-20
US5561132A (en) 1996-10-01
AU688380B2 (en) 1998-03-12
DE69431880D1 (de) 2003-01-23
EP1285657A3 (en) 2003-08-20
US5552403A (en) 1996-09-03
US5773440A (en) 1998-06-30
DE69431880T2 (de) 2003-09-18
JP2003277264A (ja) 2003-10-02
JP3683908B2 (ja) 2005-08-17
AU7798894A (en) 1995-05-04
JPH09506338A (ja) 1997-06-24
CA2173974A1 (en) 1995-04-20
CA2173974C (en) 2006-05-02
US5714486A (en) 1998-02-03
JP2005232186A (ja) 2005-09-02

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