ES438290A1 - Production of 22 thienylacetonitrile derivatives - Google Patents

Production of 22 thienylacetonitrile derivatives

Info

Publication number
ES438290A1
ES438290A1 ES438290A ES438290A ES438290A1 ES 438290 A1 ES438290 A1 ES 438290A1 ES 438290 A ES438290 A ES 438290A ES 438290 A ES438290 A ES 438290A ES 438290 A1 ES438290 A1 ES 438290A1
Authority
ES
Spain
Prior art keywords
radical
formula
carbon atoms
see formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES438290A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SINTHELABO
Original Assignee
SINTHELABO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7419476A external-priority patent/FR2273532A1/en
Priority claimed from FR7515901A external-priority patent/FR2311535A2/en
Application filed by SINTHELABO filed Critical SINTHELABO
Publication of ES438290A1 publication Critical patent/ES438290A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Procedure for preparing thienyl-2 acetonitrile derivatives, in the form of racemates or optical isomers, that respond to the general formula (I) **(See formula)** wherein it represents a hydrogen atom or a benzoyl radical which may contain from 1 to 3 halogen atoms, in particular fluorine, R2 represents a hydrogen atom, either a straight or branched chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms and which can carry a substituent chosen from the group consisting of halogens, mainly chlorine, the carboxy radical, alkoxycarbonyl radicals (the alkyl of the latter contains 1 to 3 carbon atoms) and the radicals Amines, the amine being mainly a nitrogenous heterocycle comprising from 5 to 6 links and linked to the aliphatic chain by its nitrogen atom; either finally a benzyl or alpha-hydroxy-benzyl radical; R3 R4, which are identical or different, represent, independently of each other, either a straight or branched chain alkyl radical containing from 1 to 6 carbon atoms, or a phenylalkyl radical whose alkyl has from 1 to 3 carbon atoms, or (see formula) forms a nitrogenous heterocyclic radical, containing 7 links and which may comprise a second hetero atom such as 0, S or N and carry 1 to 3 methyl or ethyl radicals, and n represents 2 or 3, with the exception of compounds for which R1 represents a hydrogen atom, R2 represents a sec-butyl radical and (see formula) represents a pyrrolidine, piperidinic or morpholinic cycle, as well as its addition salts with therapeutically acceptable mineral and organic acids, characterized in that the thienyl-2 is condensed acetonitrile with a compound of the formula: **(See formula)** and then with a compound of formula X-R2 or (see formula) and finally, optionally, with a benzoyl halide that can carry, on the phenyl nucleus, 1 to 3 halogen atoms, with the symbols R2, R3 and R4 having the meanings given above and X represents a halogen, in particular chlorine or bromine. (Machine-translation by Google Translate, not legally binding)
ES438290A 1974-06-06 1975-06-06 Production of 22 thienylacetonitrile derivatives Expired ES438290A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7419476A FR2273532A1 (en) 1974-06-06 1974-06-06 Alpha-aminoalkyl 2-thienylacetonitrile derivs - spasmolytics and vasodilators more active than papaverine
FR7515901A FR2311535A2 (en) 1975-05-22 1975-05-22 Alpha-aminoalkyl 2-thienylacetonitrile derivs - spasmolytics and vasodilators more active than papaverine

Publications (1)

Publication Number Publication Date
ES438290A1 true ES438290A1 (en) 1977-06-01

Family

ID=26218366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES438290A Expired ES438290A1 (en) 1974-06-06 1975-06-06 Production of 22 thienylacetonitrile derivatives

Country Status (3)

Country Link
JP (1) JPS51125070A (en)
DE (1) DE2525319A1 (en)
ES (1) ES438290A1 (en)

Also Published As

Publication number Publication date
DE2525319A1 (en) 1975-12-11
JPS51125070A (en) 1976-11-01

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