ES435673A1 - Xanthone carboxylic acids and derivatives - Google Patents

Xanthone carboxylic acids and derivatives

Info

Publication number
ES435673A1
ES435673A1 ES435673A ES435673A ES435673A1 ES 435673 A1 ES435673 A1 ES 435673A1 ES 435673 A ES435673 A ES 435673A ES 435673 A ES435673 A ES 435673A ES 435673 A1 ES435673 A1 ES 435673A1
Authority
ES
Spain
Prior art keywords
carboxylic acid
hydroxyalkyl
lower alkyl
xanthone
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435673A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US217383A external-priority patent/US3873714A/en
Priority claimed from US00259853A external-priority patent/US3818042A/en
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of ES435673A1 publication Critical patent/ES435673A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Abstract

A procedure for the preparation of compounds of xanthone-substituted carboxylic acid selected from those represented by the formulas: **(See formula)** and its pharmaceutically acceptable, non-toxic esters, amides and salts, where each radical R is a group selected from those of the formula: **(See formula)** where R'is hydrogen, lower alkyl, cycloalkyl, tetrahydrofuran-2-yl, tetrahydropyran-2-yl, tetrahydropyran-4yl, 4-alkoxytetrahydropyran-4-yl or carboxylic acyl containing up to 12 carbon atoms and R is lower alkyl, cycloalkyl, phenyl, substituted phenyl in which the substituent is halogen, lower alkyl, lower alkoxy, lower alkyl thio, trifluoromethyl or cyano, or a total 5- or 6-membered monocyclic aromatic heterocyclic group, one or two of which are selected from nitrogen, oxygen and sulfur, whose procedure consists of: 1) reducing a 5- or 7-acylxanthone-2-carboxylic acid ester optionally followed by hydrolysis to give the corresponding 7- (secondary hydroxyalkyl) -xanthone-2carboxylic acids or their alkyl esters; 2) optionally esterifying the hydroxyalkyl product from step 1) to give the corresponding 5- or 7-acyloxyalkylxanthone-2-carboxylic acid; 3) optionally etherifying a hydroxyalkyl product from step 1) to give the corresponding 5- or 7-hydroxyalkyl (etherified) xanthone-2-carboxylic acid and 4) optionally converting a product from steps 1), 2) and 3) to its pharmaceutically acceptable, non-toxic esters, amides and salts. (Machine-translation by Google Translate, not legally binding)
ES435673A 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives Expired ES435673A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16269671A 1971-07-14 1971-07-14
US217383A US3873714A (en) 1971-07-14 1972-01-12 Xanthone carboxylic acids and derivatives
US00259853A US3818042A (en) 1972-01-12 1972-06-05 Xanthone carboxylic acids and derivatives

Publications (1)

Publication Number Publication Date
ES435673A1 true ES435673A1 (en) 1977-07-01

Family

ID=27388786

Family Applications (6)

Application Number Title Priority Date Filing Date
ES404786A Expired ES404786A1 (en) 1971-07-14 1972-07-12 Xanthone carboxylic acids and derivatives
ES435672A Expired ES435672A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives
ES435669A Expired ES435669A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives
ES435671A Expired ES435671A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives
ES435673A Expired ES435673A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives
ES435670A Expired ES435670A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES404786A Expired ES404786A1 (en) 1971-07-14 1972-07-12 Xanthone carboxylic acids and derivatives
ES435672A Expired ES435672A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives
ES435669A Expired ES435669A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives
ES435671A Expired ES435671A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES435670A Expired ES435670A1 (en) 1971-07-14 1975-03-15 Xanthone carboxylic acids and derivatives

Country Status (11)

Country Link
AT (1) AT326121B (en)
BE (1) BE786169A (en)
CH (1) CH580093A5 (en)
DE (1) DE2234256A1 (en)
DK (1) DK141096B (en)
ES (6) ES404786A1 (en)
FR (1) FR2145654B1 (en)
GB (1) GB1386436A (en)
IL (1) IL39890A (en)
NL (1) NL7209628A (en)
SE (1) SE388421B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585876A (en) * 1982-11-25 1986-04-29 Ciba-Geigy Corporation Novel xanthones and thioxanthones

Also Published As

Publication number Publication date
ATA599372A (en) 1975-02-15
AU4445672A (en) 1974-01-17
AT326121B (en) 1975-11-25
NL7209628A (en) 1973-01-16
IL39890A (en) 1976-02-29
ES435672A1 (en) 1977-05-01
ES435670A1 (en) 1977-05-01
FR2145654A1 (en) 1973-02-23
DK141096C (en) 1980-07-14
ES404786A1 (en) 1976-01-01
DE2234256A1 (en) 1973-01-25
GB1386436A (en) 1975-03-05
BE786169A (en) 1973-01-12
SE388421B (en) 1976-10-04
DK141096B (en) 1980-01-14
ES435669A1 (en) 1977-05-01
CH580093A5 (en) 1976-09-30
ES435671A1 (en) 1977-05-01
FR2145654B1 (en) 1975-06-20

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