ES404786A1 - Xanthone carboxylic acids and derivatives - Google Patents

Abstract

A procedure for the preparation of xanthonacarboxylic acid compounds selected from those represented by the formulas: ** (See formula) ** and its pharmaceutically acceptable, non-toxic esters, amides and salts, where each radical R is a group selected from those of formulas: ** (See formula) ** where R'is hydrogen, lower alkyl, cycloalkyl, tetrahydrofuran-2-yl, tetrahydropyran-2-yl, tetrahydropyran-4-yl, 4-alkoxytetrahydropyran-4-yl or carboxylic acyl containing up to 12 carbon atoms; R1 is hydrogen, lower alkyl or cycloalkyl and R2 is hydrogen, lower alkyl, cycloalkyl, phenyl, substituted phenyl in which the substituent is halogen, lower alkyl, lower alkoxy, lower alkylthio, trifluoromethyl or cyano, or a heterocyclic group monocyclic aromatic with a total of five or six members, one or two of which are selected from nitrogen, oxygen and sulfur, whose procedure consists of: 1) condensing an O- or p-acylphenol with a 1,3-dicarboalkoxy-4-halobenzene in the presence of cuprous oxide to give the corresponding 1,3-dicarboalkoxy-4- (O- or p-acylphenyloxy) benzene, hydrolyze with a base the latter to give the corresponding 1,3-dicarboxy-4- (O or p-acylphenyloxy) -benzene and cycle the latter to give the corresponding 5- or 7-acylxanthone-2-carboxylic acid or 2) optionally converting a product from step 1) to its pharmaceutically acceptable, non-toxic esters, amides and salts. (Machine-translation by Google Translate, not legally binding)