ES432500A1 - Procedure for the obtaining of pleuromutilines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of pleuromutilines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES432500A1
ES432500A1 ES432500A ES432500A ES432500A1 ES 432500 A1 ES432500 A1 ES 432500A1 ES 432500 A ES432500 A ES 432500A ES 432500 A ES432500 A ES 432500A ES 432500 A1 ES432500 A1 ES 432500A1
Authority
ES
Spain
Prior art keywords
formula
sulfur
translation
carbon atoms
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES432500A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1445171A external-priority patent/CH559719A5/en
Priority claimed from CH773972A external-priority patent/CH568272A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES432500A1 publication Critical patent/ES432500A1/en
Expired legal-status Critical Current

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedure for obtaining substituted pleuromutilins of formula Ic, **(See formula)** where either R1 is ethyl or vinyl, n is an integer from 2 to 5, Y and Z are both sulfur, or one of Y and Z is oxygen and the other is sulfur, and each of RI2 and RI3 is alkyl of 1 to 10 carbon atoms, or RI2 and RI3 together with the nitrogen atom form a saturated 5- to 7-membered ring heterocycle containing one nitrogen atom or one nitrogen atom and an additional hetero member selected from sulfur, oxygen and a group = N-RI5, where RI5 is alkyl of 1 to 5 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms; characterized in that a compound of formula IIIa is reacted, **(See formula)** where R1, Y and Z have the meanings indicated above, with a compound of formula VI, **(See formula)** where n, RI2 and RI3 have the meanings indicated above, and A is the acidic radical of a reactive ester, conveniently in an inert solvent and at a temperature between room temperature and the boiling temperature of the mixture. (Machine-translation by Google Translate, not legally binding)
ES432500A 1971-10-05 1974-12-02 Procedure for the obtaining of pleuromutilines. (Machine-translation by Google Translate, not legally binding) Expired ES432500A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1445171A CH559719A5 (en) 1971-10-05 1971-10-05 Pleuromutilin derivs - with antibacterial activity
CH773972A CH568272A5 (en) 1972-05-25 1972-05-25 (Para-substd phenoxy- or phenylthio-acetoxy)-pleuromutilin deriv - prepd by reacting para-hydroxy or-mercapto cpds with e.g. aminoalkyl halides

Publications (1)

Publication Number Publication Date
ES432500A1 true ES432500A1 (en) 1977-03-01

Family

ID=25702062

Family Applications (1)

Application Number Title Priority Date Filing Date
ES432500A Expired ES432500A1 (en) 1971-10-05 1974-12-02 Procedure for the obtaining of pleuromutilines. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
ES (1) ES432500A1 (en)
PL (1) PL92435B1 (en)
SU (1) SU512706A3 (en)
YU (1) YU37126B (en)

Also Published As

Publication number Publication date
PL92435B1 (en) 1977-04-30
SU512706A3 (en) 1976-04-30
YU173779A (en) 1983-04-27
YU37126B (en) 1984-08-31

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