ES430966A1 - Procedure for preparing furopirrol derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for preparing furopyrrole derivatives, of general formula: **(See formula)** wherein R1 is a hydrogen atom, an alkyl radical of 1 to 3 carbon atoms, an isobutyl or t-butyl radical, a cycloalkyl radical of 4 to 8 carbon atoms, an alkenyl radical, in which the double bond is separated from the nitrogen atom of the ring by at least one carbon atom, from 3 to 4 carbon atoms, a phenyl radical, a phenyl-alkyl radical from 8 to 10 carbon atoms optionally substituted on the phenyl ring by an atom halogen; an alkanoyl radical of 2 to 4 carbon atoms; a benzoyl radical optionally substituted by one or two halogen atoms or methyl radicals or by a methoxy radical; a phenylalkanoyl radical of 8 to 10 carbon atoms optionally substituted on the phenyl ring by a halogen atom; a pyridylcarbonyl radical or a thienylcarbonyl radical and, when R1 is hydrogen or an optionally substituted alkyl, cycloalkyl, alkenyl, phenyl or phenylalkyl radical, the pharmaceutically acceptable acid addition salts thereof; characterized in that it comprises: (a) for a compound in which R1 is a hydrogen atom or an optionally substituted alkyl, cycloalkyl, alkenyl, phenyl or phenyl radical, the reaction of a compound of formula: **(See formula)** wherein X and Y, which may be the same or different, are displaceable halogen atoms or arene sulphonyloxy or alkanesulfonyloxy radicals, with a compound of formula R2-NH2 wherein R2 is a hydrogen atom or an alkyl radical of 1 to 3 atoms carbon, an isobutyl radical, t-butyl, cycloalkyl of 4 to 8 carbon atoms, alkenyl in which the double bond is separated from the nitrogen atom by at least one carbon atom, from 3 to 4 carbon atoms, phenyl or phenyl-alkyl of 8 to 10 carbon atoms optionally substituted on the phenyl ring by a halogen atom; (b) for the compound in which R1 is hydrogen, the hydrogen replacement of the radical R3 in a compound of formula: **(See formula)** wherein R3 is an alkyl radical or an α-arylalkyl radical; (o) pazet a compound in which R1 is an alkanoyl, optionally substituted benzoyl, optionally substituted phenylalkanoyl, pyridylcarbonyl or thienylcarbonyl radical, the reaction of a compound of formula: **(See formula)** with an acid, or an acid-derived acylating agent, of the formula R4CO.OH wherein R4 is an alkyl radical of 3 or 4 carbon atoms, a phenyl radical optionally substituted by one or two halogen atoms, or methyl radicals, or by a methoxy radical, a 9 or 10 carbon atom phenylalkyl radical optionally substituted on the phenyl ring by a halogen atom, a pyridyl radical or a thienyl radical. (Machine-translation by Google Translate, not legally binding)