ES430759A1 - Isoquinolines - Google Patents
IsoquinolinesInfo
- Publication number
- ES430759A1 ES430759A1 ES430759A ES430759A ES430759A1 ES 430759 A1 ES430759 A1 ES 430759A1 ES 430759 A ES430759 A ES 430759A ES 430759 A ES430759 A ES 430759A ES 430759 A1 ES430759 A1 ES 430759A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- alkoxy
- formula
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for preparing isoquinoline derivatives of formula I **(See formula)** where R is lower alkyl or cycloalkyl of 3 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms substituted by alkyl of 1 to 4 carbon atoms; α-dialkylpropynyl or α-dialkylallyl of 5 to 9 carbon atoms; hydroxyalkyl of 2 to 7 carbon atoms, the hydroxy group thereof being separated by at least two carbon atoms from the nitrogen atom to which R is attached; phenethyl; phenethyl substituted by halogen, alkyl or alkoxy of 1 to 4 carbon atoms; or adamantyl, R1 is hydrogen, halogen, alkyl or alkoxy of 1 to 4 carbon atoms, trifluoromethyl in the 5,6 or 7 position, or a nitro or A-NH- group in the 4 or 5 position, wherein A is formyl or alkanoyl of 2 to 4 carbon atoms, and R2 is hydrogen, or, when R1 is alkyl of * 1 to 4 carbon atoms, also alkyl of * 1 to 4 carbon atoms, or, when R1 is alkoxy of 1 to 4 carbon atoms, also alkoxy of 1 to 4 carbon atoms, with the general condition that the 8-position of the isoquinoline ring is unsubstituted, and that any halogen substituent present at the 3 or 4-position has a meaning other than fluorine, characterized in that it hydrolyzes a compound of formula IV, **(See formula)** where R, R1 and R2 have the meanings indicated above, and (see formula) is a group capable of being dissociated during hydrolysis, conveniently at a temperature between 0º and 80ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1430773A CH581113A5 (en) | 1973-10-08 | 1973-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES430759A1 true ES430759A1 (en) | 1977-04-16 |
Family
ID=4399720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES430759A Expired ES430759A1 (en) | 1973-10-08 | 1974-10-07 | Isoquinolines |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5082078A (en) |
| AT (1) | ATA802974A (en) |
| AU (2) | AU498889B2 (en) |
| BE (1) | BE820789A (en) |
| CA (1) | CA1021772A (en) |
| CH (1) | CH581113A5 (en) |
| DD (1) | DD114605A5 (en) |
| DE (1) | DE2447756A1 (en) |
| DK (1) | DK135766B (en) |
| ES (1) | ES430759A1 (en) |
| FI (1) | FI286374A (en) |
| FR (1) | FR2247242B1 (en) |
| GB (1) | GB1474775A (en) |
| HU (1) | HU169126B (en) |
| IL (1) | IL45797A (en) |
| NL (1) | NL7413105A (en) |
| NO (1) | NO743534L (en) |
| PH (1) | PH11611A (en) |
| SE (1) | SE7412310L (en) |
| SU (1) | SU567403A3 (en) |
| ZA (1) | ZA746409B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2611148A1 (en) * | 1975-03-26 | 1976-10-14 | Sandoz Ag | ORGANIC COMPOUNDS, THEIR USE AND MANUFACTURING |
| US4129565A (en) * | 1975-07-11 | 1978-12-12 | Nisshin Flour Milling Co., Ltd. | Isocarbostyril derivatives |
| DK166478A (en) * | 1977-05-02 | 1978-11-03 | Merck & Co Inc | PROCEDURE FOR THE PREPARATION OF NAPHTHYRIDINES |
| EP0711804A3 (en) | 1994-11-14 | 1999-09-22 | Ciba SC Holding AG | Latent light stabilizers |
| US6426415B1 (en) | 1997-09-03 | 2002-07-30 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity |
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| US6346536B1 (en) | 1997-09-03 | 2002-02-12 | Guilford Pharmaceuticals Inc. | Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same |
| US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
| US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| US6395749B1 (en) | 1998-05-15 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, methods, and compositions for inhibiting PARP activity |
| US6387902B1 (en) | 1998-12-31 | 2002-05-14 | Guilford Pharmaceuticals, Inc. | Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP |
| US6723733B2 (en) | 2000-05-19 | 2004-04-20 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses |
| WO2001091796A2 (en) | 2000-06-01 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Methods, compounds and compositions for treating gout |
-
1973
- 1973-10-08 CH CH1430773A patent/CH581113A5/xx not_active IP Right Cessation
-
1974
- 1974-09-30 DK DK514874AA patent/DK135766B/en unknown
- 1974-09-30 NO NO743534A patent/NO743534L/no unknown
- 1974-09-30 SE SE7412310A patent/SE7412310L/xx unknown
- 1974-10-01 FI FI2863/74A patent/FI286374A/fi unknown
- 1974-10-03 GB GB4290974A patent/GB1474775A/en not_active Expired
- 1974-10-04 DD DD181520A patent/DD114605A5/xx unknown
- 1974-10-04 NL NL7413105A patent/NL7413105A/en not_active Application Discontinuation
- 1974-10-07 PH PH16382A patent/PH11611A/en unknown
- 1974-10-07 BE BE149290A patent/BE820789A/en unknown
- 1974-10-07 JP JP49114815A patent/JPS5082078A/ja active Pending
- 1974-10-07 AT AT802974A patent/ATA802974A/en not_active Application Discontinuation
- 1974-10-07 DE DE19742447756 patent/DE2447756A1/en not_active Withdrawn
- 1974-10-07 CA CA210,857A patent/CA1021772A/en not_active Expired
- 1974-10-07 IL IL45797A patent/IL45797A/en unknown
- 1974-10-07 ES ES430759A patent/ES430759A1/en not_active Expired
- 1974-10-08 HU HUSA2697A patent/HU169126B/hu unknown
- 1974-10-08 AU AU74090/74A patent/AU498889B2/en not_active Expired
- 1974-10-08 SU SU7402066522A patent/SU567403A3/en active
- 1974-10-08 FR FR7433761A patent/FR2247242B1/fr not_active Expired
- 1974-10-08 ZA ZA00746409A patent/ZA746409B/en unknown
- 1974-10-09 AU AU74130/74A patent/AU7413074A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA802974A (en) | 1979-07-15 |
| IL45797A0 (en) | 1974-12-31 |
| GB1474775A (en) | 1977-05-25 |
| SU567403A3 (en) | 1977-07-30 |
| BE820789A (en) | 1975-04-07 |
| DK135766B (en) | 1977-06-20 |
| HU169126B (en) | 1976-09-28 |
| AU7413074A (en) | 1976-04-15 |
| SE7412310L (en) | 1975-04-09 |
| FR2247242A1 (en) | 1975-05-09 |
| CA1021772A (en) | 1977-11-29 |
| AU7409074A (en) | 1976-04-15 |
| AU498889B2 (en) | 1979-03-29 |
| DD114605A5 (en) | 1975-08-12 |
| FR2247242B1 (en) | 1978-07-21 |
| ZA746409B (en) | 1976-05-26 |
| NL7413105A (en) | 1975-04-10 |
| JPS5082078A (en) | 1975-07-03 |
| FI286374A (en) | 1975-04-09 |
| AU7408974A (en) | 1976-04-15 |
| IL45797A (en) | 1978-04-30 |
| DK514874A (en) | 1975-06-09 |
| CH581113A5 (en) | 1976-10-29 |
| DK135766C (en) | 1977-11-21 |
| PH11611A (en) | 1978-04-12 |
| DE2447756A1 (en) | 1975-04-10 |
| NO743534L (en) | 1975-05-05 |
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