ES445255A1 - A procedure for the preparation of 3-substitute methyl-2 or 3cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of 3-substitute methyl-2 or 3cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES445255A1 ES445255A1 ES445255A ES445255A ES445255A1 ES 445255 A1 ES445255 A1 ES 445255A1 ES 445255 A ES445255 A ES 445255A ES 445255 A ES445255 A ES 445255A ES 445255 A1 ES445255 A1 ES 445255A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- procedure
- translation
- preparation
- carboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of 3-substituted methyl-2 or 3-cephem-4-carboxylic acids of general formula: **(See formula)** where A is -S- or (see formula), R1 is hydrogen or acyl and R2'is alkyl or a heterocyclic group, or a salt or ester thereof, the procedure of which is to react a compound of general formula: **(See formula)** where A and R1 are each as defined above and Y is an aromatic heterocyclic group containing a ring N -> O group and with a bond on the carbon atom adjacent to the nitrogen atom, or a salt or ester thereof, with a compound of general formula R2'-SH (III) where R2'is as defined above, in the presence of a metal compound that chelates with compound (V) and, if necessary, reduce the resulting compound when A in said compound is (see formula) to obtain a group -S - and, if necessary, subjecting the resulting compound to an elimination reaction when said resulting compound is a salt or ester to obtain the carboxy group. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3377073A JPS5652906B2 (en) | 1973-03-24 | 1973-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES445255A1 true ES445255A1 (en) | 1977-10-16 |
Family
ID=12395671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES445255A Expired ES445255A1 (en) | 1973-03-24 | 1976-02-17 | A procedure for the preparation of 3-substitute methyl-2 or 3cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5652906B2 (en) |
| CH (1) | CH635105A5 (en) |
| ES (1) | ES445255A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0137227B1 (en) * | 1980-09-02 | 1987-12-16 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for the preparation of cephalosporin derivatives using novel thioesters |
-
1973
- 1973-03-24 JP JP3377073A patent/JPS5652906B2/ja not_active Expired
-
1976
- 1976-02-17 ES ES445255A patent/ES445255A1/en not_active Expired
-
1979
- 1979-10-30 CH CH971779A patent/CH635105A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS49117487A (en) | 1974-11-09 |
| CH635105A5 (en) | 1983-03-15 |
| JPS5652906B2 (en) | 1981-12-15 |
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