ES446565A1 - A procedure for the preparation of 1, 1- difenyl-2-hydroxy-3-aminopropan derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of 1, 1- difenyl-2-hydroxy-3-aminopropan derivatives. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES446565A1
ES446565A1 ES446565A ES446565A ES446565A1 ES 446565 A1 ES446565 A1 ES 446565A1 ES 446565 A ES446565 A ES 446565A ES 446565 A ES446565 A ES 446565A ES 446565 A1 ES446565 A1 ES 446565A1
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ES
Spain
Prior art keywords
formula
translation
hydroxy
preparation
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES446565A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES446565A1 publication Critical patent/ES446565A1/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A process for the preparation of 1,1-diphenyl-2-hydroxy-3-aminopropane derivatives of the formula: **(See formula)** where R1 is a hydrogen atom or a COR9 group where R9 is an alkyl or phenyl group; R3 is a hydrogen atom or a methyl, ethyl or benzyl group; R7 is a hydrogen atom when R8 is a fluorine, chlorine or bromine atom or a methyl, trifluoromethyl or methoxy group; and R8 is a hydrogen atom when R7 is a fluorine, chlorine or bromine atom or a methyl, trifluoromethyl or methoxy group; the process of which is to reduce with a complex metal hydride or with hydrogen and a transition metal catalyst a compound of the formula: **(See formula)** where R3, R7 and R8 are as defined above, to give a compound of formula: **(See formula)** and then, if desired, acylating the hydroxyl group. (Machine-translation by Google Translate, not legally binding)
ES446565A 1973-10-13 1976-03-31 A procedure for the preparation of 1, 1- difenyl-2-hydroxy-3-aminopropan derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES446565A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4792873 1973-10-13

Publications (1)

Publication Number Publication Date
ES446565A1 true ES446565A1 (en) 1977-10-16

Family

ID=10446764

Family Applications (1)

Application Number Title Priority Date Filing Date
ES446565A Expired ES446565A1 (en) 1973-10-13 1976-03-31 A procedure for the preparation of 1, 1- difenyl-2-hydroxy-3-aminopropan derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
AT (1) AT338241B (en)
ES (1) ES446565A1 (en)

Also Published As

Publication number Publication date
AT338241B (en) 1977-08-10
ATA141474A (en) 1976-12-15

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