ES429988A1 - Derivatives of tryptophan - Google Patents

Derivatives of tryptophan

Info

Publication number
ES429988A1
ES429988A1 ES429988A ES429988A ES429988A1 ES 429988 A1 ES429988 A1 ES 429988A1 ES 429988 A ES429988 A ES 429988A ES 429988 A ES429988 A ES 429988A ES 429988 A1 ES429988 A1 ES 429988A1
Authority
ES
Spain
Prior art keywords
salt
tryptophan
solvent
aqueous solution
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES429988A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm SpA
Original Assignee
Rotta Research Laboratorium SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Laboratorium SpA filed Critical Rotta Research Laboratorium SpA
Publication of ES429988A1 publication Critical patent/ES429988A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

In the treatment of gastro-intestinal disorders, the Na, Ca, Mg and Al salts of derivatives of DL- and L-tryptophan of the formula: < IMAGE > in X is Na, Ca, Mg or Al, n is an integer indicating the valency of X and R is a p-chlorobenzoxy or p-chlorophenyl group, show properties which are superior to those of the corresponding acids which have not been converted to a salt. The invention comprises a process for the preparation of the above salts, wherein an aqueous solution of DL- or L-tryptophan is reacted at 14-18 DEG C under alkaline conditions, due to the addition of sodium hydroxide or carbonate, with p-chlorobenzoyl chloride or p-chloro-carbobenzoxy chloride dissolved in a water-miscible organic solvent, after which the solvent is extracted with another, water-immiscible solvent. From the remaining aqueous solution, the sodium salt is precipitated by adding isopropyl alcohol, or the solution is treated with a mineral salt of Ca, Mg or Al in order to precipitate the corresponding salt (II).
ES429988A 1973-09-13 1974-09-12 Derivatives of tryptophan Expired ES429988A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39705173A 1973-09-13 1973-09-13

Publications (1)

Publication Number Publication Date
ES429988A1 true ES429988A1 (en) 1976-09-16

Family

ID=23569669

Family Applications (1)

Application Number Title Priority Date Filing Date
ES429988A Expired ES429988A1 (en) 1973-09-13 1974-09-12 Derivatives of tryptophan

Country Status (17)

Country Link
JP (1) JPS5231923B2 (en)
AT (1) AT338258B (en)
AU (1) AU468784B2 (en)
BE (1) BE819650A (en)
CA (1) CA1028332A (en)
CH (1) CH614195A5 (en)
DE (1) DE2442303A1 (en)
ES (1) ES429988A1 (en)
FI (1) FI58913C (en)
FR (1) FR2243691B1 (en)
GB (1) GB1433679A (en)
HK (1) HK38779A (en)
HU (1) HU168975B (en)
NL (1) NL7411211A (en)
NO (1) NO743260L (en)
SE (1) SE399885B (en)
ZA (1) ZA745448B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55130556U (en) * 1979-03-09 1980-09-16
JPS6314144Y2 (en) * 1979-03-16 1988-04-20
IL298502A (en) * 2020-05-24 2023-01-01 Galimedix Therapeutics Inc Crystalline forms of solvates of tryptophan derivatives, compositions comprising them and uses thereof

Also Published As

Publication number Publication date
DE2442303A1 (en) 1975-03-27
HK38779A (en) 1979-06-22
JPS5058065A (en) 1975-05-20
ZA745448B (en) 1975-09-24
NO743260L (en) 1975-04-07
HU168975B (en) 1976-08-28
CA1028332A (en) 1978-03-21
FR2243691A1 (en) 1975-04-11
FI58913B (en) 1981-01-30
AU468784B2 (en) 1976-01-22
ATA733774A (en) 1976-12-15
SE399885B (en) 1978-03-06
CH614195A5 (en) 1979-11-15
FI58913C (en) 1981-05-11
NL7411211A (en) 1975-03-17
BE819650A (en) 1974-12-31
FR2243691B1 (en) 1978-02-03
AT338258B (en) 1977-08-10
GB1433679A (en) 1976-04-28
SE7411375L (en) 1975-03-14
AU7287074A (en) 1976-01-22
FI252074A (en) 1975-03-14
JPS5231923B2 (en) 1977-08-18

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