ES429988A1 - Derivatives of tryptophan - Google Patents
Derivatives of tryptophanInfo
- Publication number
- ES429988A1 ES429988A1 ES429988A ES429988A ES429988A1 ES 429988 A1 ES429988 A1 ES 429988A1 ES 429988 A ES429988 A ES 429988A ES 429988 A ES429988 A ES 429988A ES 429988 A1 ES429988 A1 ES 429988A1
- Authority
- ES
- Spain
- Prior art keywords
- salt
- tryptophan
- solvent
- aqueous solution
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
In the treatment of gastro-intestinal disorders, the Na, Ca, Mg and Al salts of derivatives of DL- and L-tryptophan of the formula: < IMAGE > in X is Na, Ca, Mg or Al, n is an integer indicating the valency of X and R is a p-chlorobenzoxy or p-chlorophenyl group, show properties which are superior to those of the corresponding acids which have not been converted to a salt. The invention comprises a process for the preparation of the above salts, wherein an aqueous solution of DL- or L-tryptophan is reacted at 14-18 DEG C under alkaline conditions, due to the addition of sodium hydroxide or carbonate, with p-chlorobenzoyl chloride or p-chloro-carbobenzoxy chloride dissolved in a water-miscible organic solvent, after which the solvent is extracted with another, water-immiscible solvent. From the remaining aqueous solution, the sodium salt is precipitated by adding isopropyl alcohol, or the solution is treated with a mineral salt of Ca, Mg or Al in order to precipitate the corresponding salt (II).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39705173A | 1973-09-13 | 1973-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES429988A1 true ES429988A1 (en) | 1976-09-16 |
Family
ID=23569669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES429988A Expired ES429988A1 (en) | 1973-09-13 | 1974-09-12 | Derivatives of tryptophan |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS5231923B2 (en) |
AT (1) | AT338258B (en) |
AU (1) | AU468784B2 (en) |
BE (1) | BE819650A (en) |
CA (1) | CA1028332A (en) |
CH (1) | CH614195A5 (en) |
DE (1) | DE2442303A1 (en) |
ES (1) | ES429988A1 (en) |
FI (1) | FI58913C (en) |
FR (1) | FR2243691B1 (en) |
GB (1) | GB1433679A (en) |
HK (1) | HK38779A (en) |
HU (1) | HU168975B (en) |
NL (1) | NL7411211A (en) |
NO (1) | NO743260L (en) |
SE (1) | SE399885B (en) |
ZA (1) | ZA745448B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55130556U (en) * | 1979-03-09 | 1980-09-16 | ||
JPS6314144Y2 (en) * | 1979-03-16 | 1988-04-20 | ||
IL298502A (en) * | 2020-05-24 | 2023-01-01 | Galimedix Therapeutics Inc | Crystalline forms of solvates of tryptophan derivatives, compositions comprising them and uses thereof |
-
1974
- 1974-08-02 AU AU72870/74A patent/AU468784B2/en not_active Expired
- 1974-08-22 NL NL7411211A patent/NL7411211A/en unknown
- 1974-08-23 GB GB3722474A patent/GB1433679A/en not_active Expired
- 1974-08-26 ZA ZA00745448A patent/ZA745448B/en unknown
- 1974-08-28 FI FI2520/74A patent/FI58913C/en active
- 1974-09-04 DE DE2442303A patent/DE2442303A1/en not_active Withdrawn
- 1974-09-06 BE BE148301A patent/BE819650A/en not_active IP Right Cessation
- 1974-09-09 SE SE7411375A patent/SE399885B/en unknown
- 1974-09-11 CH CH1234174A patent/CH614195A5/en not_active IP Right Cessation
- 1974-09-11 NO NO743260A patent/NO743260L/no unknown
- 1974-09-11 AT AT733774A patent/AT338258B/en not_active IP Right Cessation
- 1974-09-12 FR FR7430928A patent/FR2243691B1/fr not_active Expired
- 1974-09-12 ES ES429988A patent/ES429988A1/en not_active Expired
- 1974-09-12 CA CA209,032A patent/CA1028332A/en not_active Expired
- 1974-09-12 JP JP49105439A patent/JPS5231923B2/ja not_active Expired
- 1974-09-12 HU HURO800A patent/HU168975B/hu unknown
-
1979
- 1979-06-14 HK HK387/79A patent/HK38779A/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE2442303A1 (en) | 1975-03-27 |
HK38779A (en) | 1979-06-22 |
JPS5058065A (en) | 1975-05-20 |
ZA745448B (en) | 1975-09-24 |
NO743260L (en) | 1975-04-07 |
HU168975B (en) | 1976-08-28 |
CA1028332A (en) | 1978-03-21 |
FR2243691A1 (en) | 1975-04-11 |
FI58913B (en) | 1981-01-30 |
AU468784B2 (en) | 1976-01-22 |
ATA733774A (en) | 1976-12-15 |
SE399885B (en) | 1978-03-06 |
CH614195A5 (en) | 1979-11-15 |
FI58913C (en) | 1981-05-11 |
NL7411211A (en) | 1975-03-17 |
BE819650A (en) | 1974-12-31 |
FR2243691B1 (en) | 1978-02-03 |
AT338258B (en) | 1977-08-10 |
GB1433679A (en) | 1976-04-28 |
SE7411375L (en) | 1975-03-14 |
AU7287074A (en) | 1976-01-22 |
FI252074A (en) | 1975-03-14 |
JPS5231923B2 (en) | 1977-08-18 |
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