ES429706A1 - Procedure for the obtaining of 2 (1H) quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of 2 (1H) quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES429706A1
ES429706A1 ES429706A ES429706A ES429706A1 ES 429706 A1 ES429706 A1 ES 429706A1 ES 429706 A ES429706 A ES 429706A ES 429706 A ES429706 A ES 429706A ES 429706 A1 ES429706 A1 ES 429706A1
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
radical
signify
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES429706A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES429706A1 publication Critical patent/ES429706A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for obtaining 2 (lH) -quinazolinone derivatives of formula Ij, **(See formula)** where R1 signifies a radical of formula II, **(See formula)** wherein o Z and Z1 are the same or different and signify a hydrogen, fluorine or chlorine atom, an alkyl or alkoxy radical of 1 to 3 carbon atoms, or a nitro or trifluoromethyl group, with the proviso that not more than one of Z and Z1 signify a trifluoromethyl or nitro group, or Z and Z1 are on adjacent carbon atoms and together signify a methylenedioxy group, or R1 signify a radical of formula III, **(See formula)** where Z2 signifies a hydrogen, fluorine or chlorine atom or an alkyl radical of 1 to 3 carbon atoms, x'means an oxygen or sulfur atom, R' means an alkyl radical of 1 to 5 carbon atoms, a cycloalkyl radical of 3 to 6 carbon atoms or a cycloalkylalkyl radical containing a total of 4 to 7 carbon atoms, where the cycloalkyl portion has 3 to 6 carbon atoms and the alkyl portion is a straight chain and has 1 to 3 carbon atoms, except that when R'means an alkyl radical of the 5 carbon atoms, x' means a sulfur atom, characterized in that it comprises oxidizing a compound of formula Ik, **(See formula)** wherein R', R1 and X' have the meanings indicated above, in an organic solvent that is inert under the reaction conditions, the procedure being carried out under substantially anhydrous conditions when the compound of formula Ik is a thione, conveniently at a temperature of 0º to 150ºC when the starting material is a -thione and conveniently a temperature of 0º to 120ºC when the starting material is an -one. (Machine-translation by Google Translate, not legally binding)
ES429706A 1971-05-06 1974-08-31 Procedure for the obtaining of 2 (1H) quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES429706A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14101171A 1971-05-06 1971-05-06
US14099071A 1971-05-06 1971-05-06

Publications (1)

Publication Number Publication Date
ES429706A1 true ES429706A1 (en) 1977-03-16

Family

ID=26838683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES429706A Expired ES429706A1 (en) 1971-05-06 1974-08-31 Procedure for the obtaining of 2 (1H) quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
AT (2) ATA393472A (en)
CA (1) CA983930A (en)
CH (2) CH551423A (en)
ES (1) ES429706A1 (en)
HU (1) HU164668B (en)

Also Published As

Publication number Publication date
CH551423A (en) 1974-07-15
ATA324474A (en) 1975-06-15
CH551419A (en) 1974-07-15
HU164668B (en) 1974-03-28
ATA393472A (en) 1975-05-15
AT328442B (en) 1976-03-25
CA983930A (en) 1976-02-17

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