ES404833A1 - Tricyclic quinazolinone derivatives - Google Patents
Tricyclic quinazolinone derivativesInfo
- Publication number
- ES404833A1 ES404833A1 ES404833A ES404833A ES404833A1 ES 404833 A1 ES404833 A1 ES 404833A1 ES 404833 A ES404833 A ES 404833A ES 404833 A ES404833 A ES 404833A ES 404833 A1 ES404833 A1 ES 404833A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- radical
- formula
- hydroxy group
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining quinazolinone derivatives of formula I, ** (See formula) ** wherein either R1 and R2 are the same or different, and each signifies a hydrogen, fluorine, or chlorine atom, or an alkyl radical of 1 to 3 carbon atoms, or each of R1 and R2 signifies a hydroxy group, or each one of R1 and R2 means an alkoxy radical of 1 or 2 carbon atoms, or one of R1 and R2 means an atom of bromine, a hydroxy radical, or an alkoxy radical of 1 or 2 carbon atoms, and the other symbol means a hydrogen atom, n denotes 1, 2 or 3, and or R denotes an alkyl radical of 1 to 5 carbon atoms, or R denotes a radical of formula III or IV, ** (See formula) ** where m is 1 or 2, i Y and Y1 are the same or different, and each is a hydrogen, fluorine, or chlorine atom, or an alkyl radical of 1 to 3 carbon atoms, or each of Y and Y1 is a hydroxy group or each of Y and Y1 signifies an alkoxy radical of 1 or 2 carbon atoms, or one of Y and Y1 signifies a bromine atom, a hydroxy group, or an alkoxy radical of 1 or 2 carbon atoms, and the other symbol means a hydrogen atom, provided that (i) no more than two of R1, R2, Y and Y1 signify a hydroxy group, (ii) each of R1 and R2 have a meaning other than a hydroxy group when Y or Y1 means an alkoxy radical of 1 or 2 carbon atoms, (iii) each of Y and Y1 has a meaning other than a hydroxy group when R1 or R2 means an alkoxy radical of 1 or 2 atoms carbon, (iv) when R means an alkyl radical of 1 to 5 carbon atoms, or a radical of formula III, where m means 1, and each of Y and Y1 means a hydrogen atom, so at least one of R1 and R2 has the meaning other than a hydrogen, fluorine or chlorine atom, and R1 and R2 cannot both mean an alkoxy radical of 1 or 2 carbon atoms, characterized why a compound of formula V is reacted, ** (See formula) ** wherein R, R1 and R2 have the meanings indicated above, with a compound of formula VI, ** (See formula) ** where n has the meaning indicated above, W means an oxygen or sulfur atom, and R4 means an alkyl radical of 1 to 4 carbon atoms, or a benzyl radical, in the presence of an inert organic solvent, include cyclic ethers or aromatic solvents, conveniently at a temperature of 20 to 160ºC, preferably 80 to 120ºC and preferably in the presence of a base. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16310571A | 1971-07-15 | 1971-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES404833A1 true ES404833A1 (en) | 1976-01-01 |
Family
ID=22588501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES404833A Expired ES404833A1 (en) | 1971-07-15 | 1972-07-13 | Tricyclic quinazolinone derivatives |
Country Status (13)
| Country | Link |
|---|---|
| AR (1) | AR199553A1 (en) |
| AU (1) | AU4455572A (en) |
| BE (1) | BE786254R (en) |
| DD (1) | DD98932A5 (en) |
| DE (1) | DE2234174A1 (en) |
| ES (1) | ES404833A1 (en) |
| FR (1) | FR2145629B2 (en) |
| GB (1) | GB1392254A (en) |
| HU (1) | HU164961B (en) |
| IL (1) | IL39901A0 (en) |
| NL (1) | NL7209551A (en) |
| OA (1) | OA04135A (en) |
| ZA (1) | ZA724874B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3220438A1 (en) * | 1982-05-29 | 1983-12-01 | Troponwerke GmbH & Co KG, 5000 Köln | CHINAZOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS |
-
0
- BE BE786254D patent/BE786254R/en active
-
1972
- 1972-07-10 NL NL7209551A patent/NL7209551A/xx unknown
- 1972-07-11 GB GB3234272A patent/GB1392254A/en not_active Expired
- 1972-07-12 FR FR7225239A patent/FR2145629B2/fr not_active Expired
- 1972-07-12 DD DD164377A patent/DD98932A5/xx unknown
- 1972-07-12 DE DE2234174A patent/DE2234174A1/en active Pending
- 1972-07-13 AU AU44555/72A patent/AU4455572A/en not_active Expired
- 1972-07-13 IL IL39901A patent/IL39901A0/en unknown
- 1972-07-13 HU HUSA2374A patent/HU164961B/hu unknown
- 1972-07-13 ES ES404833A patent/ES404833A1/en not_active Expired
- 1972-07-14 OA OA54642A patent/OA04135A/en unknown
- 1972-07-14 AR AR243077A patent/AR199553A1/en active
- 1972-07-14 ZA ZA724874A patent/ZA724874B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1392254A (en) | 1975-04-30 |
| ZA724874B (en) | 1974-02-27 |
| DE2234174A1 (en) | 1973-01-25 |
| FR2145629B2 (en) | 1976-04-16 |
| AR199553A1 (en) | 1974-09-13 |
| AU4455572A (en) | 1974-01-17 |
| BE786254R (en) | 1973-01-15 |
| HU164961B (en) | 1974-05-28 |
| NL7209551A (en) | 1973-01-17 |
| DD98932A5 (en) | 1973-07-12 |
| FR2145629A2 (en) | 1973-02-23 |
| IL39901A0 (en) | 1972-09-28 |
| OA04135A (en) | 1979-11-30 |
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