ES357216A2 - Procedure for the preparation of derivatives of isoindol (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of derivatives of isoindol (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES357216A2
ES357216A2 ES357216A ES357216A ES357216A2 ES 357216 A2 ES357216 A2 ES 357216A2 ES 357216 A ES357216 A ES 357216A ES 357216 A ES357216 A ES 357216A ES 357216 A2 ES357216 A2 ES 357216A2
Authority
ES
Spain
Prior art keywords
hydrogen
chlorine
fluorine atom
formula
meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES357216A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES357216A2 publication Critical patent/ES357216A2/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
    • C07C51/23—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of oxygen-containing groups to carboxyl groups
    • C07C51/245—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of oxygen-containing groups to carboxyl groups of keto groups or secondary alcohol groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Improvements introduced in the object of the main patent nº351.834, filed on March 21, 1968, for: "PROCEDURE FOR THE PREPARATION OF ISOINDOL DERIVATIVES" of formula I, **(See formula)** wherein each of R, R1, and R2, which may be identical or different, signifies a hydrogen, chlorine, or fluorine atom, or a trifluoromethyl radical, a straight-chain alkyl radical of 1 to 4 carbon atoms, or a straight chain alkoxy radical of 1 to 4 carbon atoms, provided that 1) R, R1 and R2 have a meaning such that a trifluoromethyl radical is never found in each of two adjacent carbon atoms, and 2) when R or R2 is a trifluoromethyl radical, R1 is a hydrogen, chlorine or fluorine atom, each of R3, R4 and R5, which may be identical or different, means a hydrogen, chlorine or fluorine atom, and R6 means a hydrogen or fluorine atom, with the additional conditions that not more than two of R3, R4, R5, and R6 have a meaning other than hydrogen, and that not more than three of R, R1, R2, R3, R4, R5 and R6 have a meaning other than hydrogen with R preferably chlorine or hydrogen, R1 chlorine and R2 to R6 hydrogen, charac bristling because a compound of formula II **(See formula)** in which R to R6 have the meanings indicated above, it is reduced with lithium aluminum hydride in an inert ether solvent, under an inert atmosphere, preferably in tetrohydrofuran under a nitrogen atmosphere, the reduction being carried out at the reflux temperature, preferably at a temperature between 45 and 85ºC, and the resulting reduced product of formula III: **(See formula)** wherein the various radicals are defined as above, a weak oxidizing agent, such as air or oxygen, is contacted, preferably by introducing air or oxygen into a solution of said reduced product in an inert organic solvent. (Machine-translation by Google Translate, not legally binding)
ES357216A 1967-03-23 1968-08-13 Procedure for the preparation of derivatives of isoindol (Machine-translation by Google Translate, not legally binding) Expired ES357216A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62529967A 1967-03-23 1967-03-23
ES351834A ES351834A1 (en) 1967-03-23 1968-03-21 Procedure for the preparation of derivatives of isoindol. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES357216A2 true ES357216A2 (en) 1971-01-16

Family

ID=24505431

Family Applications (3)

Application Number Title Priority Date Filing Date
ES351834A Expired ES351834A1 (en) 1967-03-23 1968-03-21 Procedure for the preparation of derivatives of isoindol. (Machine-translation by Google Translate, not legally binding)
ES357216A Expired ES357216A2 (en) 1967-03-23 1968-08-13 Procedure for the preparation of derivatives of isoindol (Machine-translation by Google Translate, not legally binding)
ES368450A Expired ES368450A2 (en) 1967-03-23 1969-06-17 Procedure for the preparation of derivatives of isoindol (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES351834A Expired ES351834A1 (en) 1967-03-23 1968-03-21 Procedure for the preparation of derivatives of isoindol. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES368450A Expired ES368450A2 (en) 1967-03-23 1969-06-17 Procedure for the preparation of derivatives of isoindol (Machine-translation by Google Translate, not legally binding)

Country Status (12)

Country Link
AT (1) AT299187B (en)
BE (1) BE712596A (en)
DE (2) DE1770030A1 (en)
DK (1) DK136117B (en)
ES (3) ES351834A1 (en)
FI (1) FI48840C (en)
FR (1) FR7623M (en)
GB (1) GB1225411A (en)
MY (1) MY7300316A (en)
NL (1) NL6803799A (en)
NO (1) NO130826C (en)
SE (1) SE335349B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770009C2 (en) * 1968-03-20 1987-04-16 American Home Products Corp., New York, N.Y. Process for the preparation of imidazolinyl compounds
CH530980A (en) * 1969-03-05 1972-11-30 Sandoz Ag Process for the preparation of imidazo (2,1-a) isoindoles
US4200759A (en) * 1978-07-20 1980-04-29 Delmar Chemicals, Limited Preparation of imidazo[2,1-a]isoindole compounds
DE19720859A1 (en) * 1997-05-13 1998-11-19 Inst Chemo Biosensorik Electrical connection arrangement for sensor to measurement device

Also Published As

Publication number Publication date
NO130826C (en) 1975-02-19
SE335349B (en) 1971-05-24
GB1225411A (en) 1971-03-17
ES368450A2 (en) 1971-07-16
AT299187B (en) 1972-06-12
DE1770030A1 (en) 1971-09-23
BE712596A (en) 1968-09-23
FI48840C (en) 1975-01-10
DK136117C (en) 1978-01-16
DK136117B (en) 1977-08-15
NO130826B (en) 1974-11-11
MY7300316A (en) 1973-12-31
ES351834A1 (en) 1969-12-01
DE1795758A1 (en) 1974-10-10
FR7623M (en) 1970-01-26
NL6803799A (en) 1968-09-24
FI48840B (en) 1974-09-30

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