ES429701A1 - A procedure for the production of acids 6, 11-dihidrodibenz (b, e) -oxepin-acetics and their derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the production of acids 6, 11-dihidrodibenz (b, e) -oxepin-acetics and their derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES429701A1
ES429701A1 ES429701A ES429701A ES429701A1 ES 429701 A1 ES429701 A1 ES 429701A1 ES 429701 A ES429701 A ES 429701A ES 429701 A ES429701 A ES 429701A ES 429701 A1 ES429701 A1 ES 429701A1
Authority
ES
Spain
Prior art keywords
alcohol
carbon atoms
oxepin
translation
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES429701A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES429701A1 publication Critical patent/ES429701A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A process for the production of 6,11-dihydrodibenz [b, e] -oxepin-acetic acids and their derivatives, of the formula **(See formula)** where X is C = 0, CHC1, CHBr, CH2 or CHOR4; Y is alcohol or alkoxy of 1 to 4 carbon atoms, F, C1, Brotrifluoromethyl; n is 0, 1, 2o3; Z is COOR5, CH2OR5, CONHR5, C0HR52 or CONHOR5; and R1, R2, R3, R4 and R5 are hydrogen or 1-4-carbon alcohol, and their physiologically tolerable salts, in a multi-step reaction, comprising reacting an alpha-bromo-o-toluic acid ester substituted by n groups Y, where n is 0, 1, 2 or 3, and Y being alcohol or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl, and an aliphatic alcohol of 1 to 4 carbon atoms, with an ester of hydroxyphenylacetic acid substituted in the alpha position by R1 or R2, R1 and R2 representing hydrogen or alcohol of 1 to 4 carbon atoms, then saponify the resulting diester to give the corresponding diacid, and then cyclize this diacid by dehydration, to give the corresponding 6,11-dihydro-11-oxodibenz [b, e] oxepine-acetic acid substituted derivative. (Machine-translation by Google Translate, not legally binding)
ES429701A 1973-09-06 1974-08-31 A procedure for the production of acids 6, 11-dihidrodibenz (b, e) -oxepin-acetics and their derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES429701A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39480173A 1973-09-06 1973-09-06

Publications (1)

Publication Number Publication Date
ES429701A1 true ES429701A1 (en) 1977-02-16

Family

ID=23560476

Family Applications (1)

Application Number Title Priority Date Filing Date
ES429701A Expired ES429701A1 (en) 1973-09-06 1974-08-31 A procedure for the production of acids 6, 11-dihidrodibenz (b, e) -oxepin-acetics and their derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
BE (1) BE819637A (en)
ES (1) ES429701A1 (en)
HU (1) HU172797B (en)
ZA (1) ZA745665B (en)

Also Published As

Publication number Publication date
HU172797B (en) 1978-12-28
BE819637A (en) 1975-03-06
ZA745665B (en) 1976-02-25

Similar Documents

Publication Publication Date Title
IE39835B1 (en) Oxepin derivatives
SE7510041L (en) PROCEDURE FOR THE PREPARATION OF BENSOTIAZINE COMPOUNDS
ES439811A1 (en) Benzimidazole derivatives and process for the production thereof
EP0023849A3 (en) Substituted pentenoic acid, preparation thereof, its application in the preparation of substituted cyclopropane derivatives; substituted gamma-lactones
ES429701A1 (en) A procedure for the production of acids 6, 11-dihidrodibenz (b, e) -oxepin-acetics and their derivatives. (Machine-translation by Google Translate, not legally binding)
ES396473A1 (en) Isoindorinjudotaino seiho
GB1071818A (en) Novel indane derivatives and processes for their preparation
SE7706509L (en) SPIRO ((7-ACYLTIO-4-OSTREN OR-ANDROSTEN-3-ON) -17 BETA, 2 '- (4'-CARBONIC ACID-1'-OXACYCLOPENTAN-5'-ON)) AND ESTRES THEREOF
ES442886A1 (en) D-6-methyl-2,8-disubstituted ergolines
ES449817A1 (en) Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides
ES468013A1 (en) A procedure for the preparation of amino acid esters. (Machine-translation by Google Translate, not legally binding)
ES405643A1 (en) Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES429957A1 (en) Process for the preparation of an ester of an alkyl-or alkenyl succinic acid and a polyvalent alcohol
ES379619A1 (en) A process for the manufacture of amino acids and derivatives thereof
JPS5612355A (en) Manufacture of optically active alphaacyanoalcohol
KR790000592B1 (en) Method of preparing 6,11-dihydrodibenz(b,e)oxepin-aceticaccids and derivatives
SE8503439L (en) SET FOR PREPARATION OF 2,3,5-COLLIDIN AND / OR 2,3,5,6-TETRAMETHYLPYRIDINE
ES432790A1 (en) A method for producing derivatives of 2-chloropropic acid. (Machine-translation by Google Translate, not legally binding)
ES406131A1 (en) Procedure for the preparation of acids 4- (4-bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
MX3366E (en) PROCEDURE FOR THE PREPARATION OF OMEGA ACIDS- (6,11-DIHIDRO-11-OXODIBENZ (B, E,) OXEPIN-2-IL) - ALKANOIC
ES366534A1 (en) 1,2-oxazinyl phenyl alkanoic acids
ES417810A1 (en) A procedure for obtaining 2-6 bismetanolpiridine. (Machine-translation by Google Translate, not legally binding)
ES444541A1 (en) Process for preparing 1,4-naphthalene-dicarboxylic acid esters
ES474535A1 (en) Procedure for the obtaining of new derivatives of naftalen acetic acids with analgesic and anti-inflammatory activity. (Machine-translation by Google Translate, not legally binding)
ES444634A2 (en) Procedure for the preparation of derivatives of isoindoline. (Machine-translation by Google Translate, not legally binding)