ES423289A1 - Procedimiento para preparar derivados de leurosina. - Google Patents
Procedimiento para preparar derivados de leurosina.Info
- Publication number
- ES423289A1 ES423289A1 ES423289A ES423289A ES423289A1 ES 423289 A1 ES423289 A1 ES 423289A1 ES 423289 A ES423289 A ES 423289A ES 423289 A ES423289 A ES 423289A ES 423289 A1 ES423289 A1 ES 423289A1
- Authority
- ES
- Spain
- Prior art keywords
- leurosine
- derivatives
- acid addition
- preparing
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LPGWZGMPDKDHEP-HLTPFJCJSA-N Leurosine Chemical class C([C@]1([C@@H]2O1)CC)N(CCC=1C3=CC=CC=C3NC=11)C[C@H]2C[C@]1(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC LPGWZGMPDKDHEP-HLTPFJCJSA-N 0.000 title abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- LPGWZGMPDKDHEP-GKWAKPNHSA-N Leurosine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@]6(CC)O[C@@H]6[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C LPGWZGMPDKDHEP-GKWAKPNHSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HURI502A HU165986B (en, 2012) | 1973-02-16 | 1973-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES423289A1 true ES423289A1 (es) | 1976-04-16 |
Family
ID=11000914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES423289A Expired ES423289A1 (es) | 1973-02-16 | 1974-02-15 | Procedimiento para preparar derivados de leurosina. |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US4189432A (en, 2012) |
| JP (1) | JPS5221520B2 (en, 2012) |
| AT (1) | AT332566B (en, 2012) |
| BE (1) | BE811110A (en, 2012) |
| BG (1) | BG21415A3 (en, 2012) |
| CA (1) | CA1029017A (en, 2012) |
| CH (1) | CH592101A5 (en, 2012) |
| CS (1) | CS181737B2 (en, 2012) |
| DD (1) | DD110276A5 (en, 2012) |
| DE (1) | DE2404120C3 (en, 2012) |
| DK (1) | DK138459B (en, 2012) |
| ES (1) | ES423289A1 (en, 2012) |
| FI (1) | FI57760C (en, 2012) |
| FR (1) | FR2218095B1 (en, 2012) |
| GB (1) | GB1412932A (en, 2012) |
| HU (1) | HU165986B (en, 2012) |
| IL (1) | IL43963A (en, 2012) |
| NL (1) | NL159390B (en, 2012) |
| NO (1) | NO139441C (en, 2012) |
| PL (1) | PL88630B1 (en, 2012) |
| RO (1) | RO65486A (en, 2012) |
| SE (1) | SE407687B (en, 2012) |
| SU (1) | SU576951A3 (en, 2012) |
| YU (1) | YU35893B (en, 2012) |
| ZA (1) | ZA741015B (en, 2012) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2296418B1 (en, 2012) * | 1974-12-30 | 1978-07-21 | Anvar | |
| US4096148A (en) * | 1976-12-06 | 1978-06-20 | Eli Lilly And Company | Oxazolidinedione derivatives of Vinca alkaloids |
| FR2387237A2 (fr) | 1977-04-13 | 1978-11-10 | Anvar | Procede perfectionne de synthese de la leusorosine et de ses derives |
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
| FR2651348B1 (en, 2012) * | 1989-08-04 | 1993-01-22 | Adir | |
| US6326402B1 (en) | 1998-08-12 | 2001-12-04 | Octamer, Inc. | Methods for treating viral infections using a compound capable of inhibiting microtubules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3392173A (en) * | 1964-03-09 | 1968-07-09 | Lilly Co Eli | Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation |
| US4065457A (en) * | 1973-05-19 | 1977-12-27 | Beecham Group Limited | 4-Hydroxy-3-nitro-carbostyril compounds |
-
1973
- 1973-02-16 HU HURI502A patent/HU165986B/hu unknown
- 1973-12-05 US US05/422,100 patent/US4189432A/en not_active Expired - Lifetime
-
1974
- 1974-01-06 IL IL43963A patent/IL43963A/en unknown
- 1974-01-09 SE SE7400242A patent/SE407687B/xx not_active IP Right Cessation
- 1974-01-18 YU YU133/74A patent/YU35893B/xx unknown
- 1974-01-22 FR FR7402023A patent/FR2218095B1/fr not_active Expired
- 1974-01-24 NO NO740228A patent/NO139441C/no unknown
- 1974-01-28 AT AT65374*#A patent/AT332566B/de not_active IP Right Cessation
- 1974-01-28 GB GB380374A patent/GB1412932A/en not_active Expired
- 1974-01-29 RO RO7477436A patent/RO65486A/ro unknown
- 1974-01-29 CH CH115274A patent/CH592101A5/xx not_active IP Right Cessation
- 1974-01-29 DE DE2404120A patent/DE2404120C3/de not_active Expired
- 1974-02-01 NL NL7401416.A patent/NL159390B/xx not_active IP Right Cessation
- 1974-02-01 BG BG025677A patent/BG21415A3/xx unknown
- 1974-02-04 DD DD176359A patent/DD110276A5/xx unknown
- 1974-02-05 CS CS7400000795A patent/CS181737B2/cs unknown
- 1974-02-07 FI FI347/74A patent/FI57760C/fi active
- 1974-02-14 DK DK78474AA patent/DK138459B/da not_active IP Right Cessation
- 1974-02-14 PL PL1974168805A patent/PL88630B1/pl unknown
- 1974-02-14 CA CA192,497A patent/CA1029017A/en not_active Expired
- 1974-02-15 ES ES423289A patent/ES423289A1/es not_active Expired
- 1974-02-15 ZA ZA00741015A patent/ZA741015B/xx unknown
- 1974-02-15 SU SU7401999265A patent/SU576951A3/ru active
- 1974-02-15 JP JP49018422A patent/JPS5221520B2/ja not_active Expired
- 1974-02-15 BE BE140981A patent/BE811110A/xx not_active IP Right Cessation
-
1976
- 1976-11-17 US US05/742,463 patent/US4279915A/en not_active Expired - Lifetime
-
1977
- 1977-09-20 US US05/834,871 patent/US4279916A/en not_active Expired - Lifetime
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