ES416780A1 - Procedimiento para la preparacion de nuevas 1,4-benzodiaze-pinas. - Google Patents
Procedimiento para la preparacion de nuevas 1,4-benzodiaze-pinas.Info
- Publication number
- ES416780A1 ES416780A1 ES416780A ES416780A ES416780A1 ES 416780 A1 ES416780 A1 ES 416780A1 ES 416780 A ES416780 A ES 416780A ES 416780 A ES416780 A ES 416780A ES 416780 A1 ES416780 A1 ES 416780A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- general formula
- radicals
- alcohol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 9
- -1 morpholino, thiomorpholino Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722234150 DE2234150A1 (de) | 1972-07-12 | 1972-07-12 | Neue 1,4-benzodiazepine |
| DE2324962A DE2324962A1 (de) | 1973-05-15 | 1973-05-15 | Neue 1,4-benzodiazepine |
| DE19732326657 DE2326657A1 (de) | 1973-05-25 | 1973-05-25 | Neue verfahren zur herstellung von 1,4-benzodiazepinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES416780A1 true ES416780A1 (es) | 1976-03-16 |
Family
ID=27184564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES416780A Expired ES416780A1 (es) | 1972-07-12 | 1973-07-11 | Procedimiento para la preparacion de nuevas 1,4-benzodiaze-pinas. |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4985080A (en。) |
| AT (2) | AT329572B (en。) |
| AU (1) | AU475257B2 (en。) |
| BG (2) | BG20802A3 (en。) |
| CA (1) | CA1006512A (en。) |
| CH (1) | CH590252A5 (en。) |
| CS (1) | CS176244B2 (en。) |
| DD (1) | DD106172A5 (en。) |
| DK (1) | DK138115C (en。) |
| ES (1) | ES416780A1 (en。) |
| GB (1) | GB1392143A (en。) |
| HU (1) | HU167867B (en。) |
| IE (1) | IE37904B1 (en。) |
| IL (1) | IL42720A (en。) |
| PL (1) | PL93110B1 (en。) |
-
1973
- 1973-07-09 CH CH1000373A patent/CH590252A5/xx not_active IP Right Cessation
- 1973-07-10 BG BG024075A patent/BG20802A3/xx unknown
- 1973-07-10 BG BG025335A patent/BG20374A3/xx unknown
- 1973-07-10 DD DD172188A patent/DD106172A5/xx unknown
- 1973-07-11 HU HUTO915A patent/HU167867B/hu unknown
- 1973-07-11 JP JP48078240A patent/JPS4985080A/ja active Pending
- 1973-07-11 DK DK385273A patent/DK138115C/da active
- 1973-07-11 AT AT1008574*7A patent/AT329572B/de not_active IP Right Cessation
- 1973-07-11 GB GB3307273A patent/GB1392143A/en not_active Expired
- 1973-07-11 AU AU57997/73A patent/AU475257B2/en not_active Expired
- 1973-07-11 CA CA176,230A patent/CA1006512A/en not_active Expired
- 1973-07-11 ES ES416780A patent/ES416780A1/es not_active Expired
- 1973-07-11 IL IL42720A patent/IL42720A/en unknown
- 1973-07-11 AT AT608873A patent/AT327922B/de not_active IP Right Cessation
- 1973-07-11 PL PL1973163989A patent/PL93110B1/pl unknown
- 1973-07-12 IE IE1180/73A patent/IE37904B1/xx unknown
- 1973-07-12 CS CS5021A patent/CS176244B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1006512A (en) | 1977-03-08 |
| DK138115B (da) | 1978-07-17 |
| DK138115C (da) | 1978-12-18 |
| ATA1008574A (de) | 1975-08-15 |
| ATA608873A (de) | 1975-05-15 |
| IL42720A (en) | 1976-06-30 |
| JPS4985080A (en。) | 1974-08-15 |
| IE37904B1 (en) | 1977-11-09 |
| AU475257B2 (en) | 1976-08-19 |
| AU5799773A (en) | 1975-01-16 |
| GB1392143A (en) | 1975-04-30 |
| CH590252A5 (en。) | 1977-07-29 |
| CS176244B2 (en。) | 1977-06-30 |
| AT327922B (de) | 1976-02-25 |
| BG20374A3 (bg) | 1975-11-05 |
| AT329572B (de) | 1976-05-25 |
| DD106172A5 (en。) | 1974-06-05 |
| PL93110B1 (en。) | 1977-05-30 |
| BG20802A3 (bg) | 1975-12-20 |
| IL42720A0 (en) | 1973-11-28 |
| HU167867B (en。) | 1975-12-25 |
| IE37904L (en) | 1974-01-12 |
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