ES416478A1 - Oral compositions for plaque caries and calculus retardation with reduced staining tendencies - Google Patents
Oral compositions for plaque caries and calculus retardation with reduced staining tendenciesInfo
- Publication number
- ES416478A1 ES416478A1 ES416478A ES416478A ES416478A1 ES 416478 A1 ES416478 A1 ES 416478A1 ES 416478 A ES416478 A ES 416478A ES 416478 A ES416478 A ES 416478A ES 416478 A1 ES416478 A1 ES 416478A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- hydrogen
- see formula
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Dental Preparations (AREA)
Abstract
Procedure for preparing compositions effective in inhibiting plaque formation, caries and stones, characterized in that it comprises reacting, at a pH of 4 to 9 (A) of approximately 0.01 to 2.5% by weight of the composition of a bis-biguanide compound with the generic formula: **(See formula)** wherein A and A'each represent a phenyl radical, which may contain as a substituent up to two alkyl or alkoxy groups containing from about 1 to 4 carbon atoms, a nitro group or a halogen atom; an alkyl group containing from about 1 to 12 carbon atoms; or alicyclic groups containing from 4 to 12 carbon atoms approximately; wherein X and X'each represent an alkylene radical containing 1 to 3 carbon atoms; where z and z'can each be 0 or 1; wherein R and R'each represent hydrogen, an alkyl radical containing from about 1 to 12 carbon atoms, or an aralkyl radical containing from about 7 to 12 carbon atoms; where n is an integer from 2 to 12, inclusive; and in which the polymethylene (CH2) n chain can be interrupted with a maximum of 5 halves of ether, thioether, phenyl, or naphthyl; or its pharmaceutically acceptable salts; with (B) a quantity of a compound inhibitor of the formation of stones soluble in water and containing phosphorous selected from the group consisting of: **(See formula)** wherein R1 and R2 are hydrogen or CH2OH; n is an integer from 3 to 10; R3 is hydrogen, alkyl containing from about 1 to 20 carbon atoms, alkenyl containing from about 2 to 20 carbon atoms, phenyl, naphthyl, phenylethenyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamine, acetylamino, -CH2COOH, -CH2PO3H2, -CH (PO3H2) (OH) or -CH2CH (PO3H2) 2; and R4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, -CH2COOH, -CH2PO3H2, or -CH2CH2PO3H2; **(See formula)** wherein R5, R6, R7, R8, R9 and R10 are each hydrogen or lower alkyl; **(See formula)** where n is an integer from 3 to 9; **(See formula)** where X and Y are each hydrogen or hydroxy; or a pharmaceutically acceptable salt thereof; or the condensation products of ammonia and phosphorous pentoxide, which comprises the compounds: **(See formula)** such being the amount of said compound that inhibits the formation of stones soluble in water and containing phosphorus that provides from 0.01 to 10% by weight of the composition of said anti-stone compound above that which reacts with said bis-biguanide compound. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26781672A | 1972-06-30 | 1972-06-30 | |
| US33847273A | 1973-03-06 | 1973-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES416478A1 true ES416478A1 (en) | 1976-06-01 |
Family
ID=26952666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES416478A Expired ES416478A1 (en) | 1972-06-30 | 1973-06-30 | Oral compositions for plaque caries and calculus retardation with reduced staining tendencies |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS4966838A (en) |
| AT (1) | AT333969B (en) |
| AU (1) | AU474403B2 (en) |
| CA (1) | CA1001554A (en) |
| CH (1) | CH595100A5 (en) |
| DE (1) | DE2332383A1 (en) |
| DK (1) | DK135789B (en) |
| ES (1) | ES416478A1 (en) |
| FR (1) | FR2190459B1 (en) |
| GB (1) | GB1432487A (en) |
| IE (1) | IE37842B1 (en) |
| NL (1) | NL7309090A (en) |
| SE (1) | SE403963B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1458476A (en) * | 1975-06-23 | 1977-12-08 | Procter & Gamble | Bis-biguanide compounds |
| SE431285B (en) * | 1976-08-16 | 1984-01-30 | Colgate Palmolive Co | MUNVARDS COMPOSITION CONTAINING A PHOSPHONE SOCIETY, FOR REDUCING MISSING DIFFERENCE PICTURED BY AN INCLUDING NITROGEN ANTIBACTERIAL PLAQUE |
| JPS5840523B2 (en) * | 1976-08-26 | 1983-09-06 | 松風陶歯製造株式会社 | Dental primer composition |
| IT1201087B (en) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | PHARMACOLOGICALLY ACTIVE BIPPHOSPHONES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS |
| US4961923A (en) * | 1988-02-19 | 1990-10-09 | Dentsply Management Corp. | Irrigants for use in scaling and/or lavage apparatus |
| US6190642B1 (en) | 1988-02-19 | 2001-02-20 | Dentsply Research & Development Corp. | Irrigating and lavage compositions |
| US5438076A (en) * | 1988-05-03 | 1995-08-01 | Perio Products, Ltd. | Liquid polymer composition, and method of use |
| US6214320B1 (en) | 1990-10-09 | 2001-04-10 | Colgate-Palmolive Company | Oral compositions containing anticalculus and antiplaque agents |
| EP3100716B1 (en) | 2008-02-08 | 2018-09-26 | Colgate-Palmolive Company | Novel salts and their uses |
| MX361642B (en) | 2013-09-13 | 2018-12-13 | 3M Innovative Properties Co | Cationic antiseptic compositions. |
| CN111138660B (en) * | 2019-12-20 | 2020-12-08 | 浙江大学 | Preparation method of fluorinated polyhexamethylene biguanide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6568736D0 (en) * | 1964-04-09 | 1973-08-14 | Drug Inc Sterling | PROCESS TO PREPARE A BISGUANIDE |
| IT1002501B (en) * | 1965-05-03 | 1976-05-20 | Colgate Palmolive Co | TOOTHPASTE COMPOSITIONS |
| BE722631A (en) * | 1965-12-08 | 1969-04-21 | ||
| US3639569A (en) * | 1968-02-19 | 1972-02-01 | Procter & Gamble | Oral compositions for calculus retardation |
| US3562385A (en) * | 1968-12-23 | 1971-02-09 | Merck & Co Inc | Dental antiplaque and anticalculus compositions |
| BE730888A (en) * | 1969-04-01 | 1969-09-15 |
-
1973
- 1973-06-25 IE IE104873A patent/IE37842B1/en unknown
- 1973-06-26 DE DE19732332383 patent/DE2332383A1/en active Pending
- 1973-06-28 AU AU57451/73A patent/AU474403B2/en not_active Expired
- 1973-06-28 DK DK358773A patent/DK135789B/en unknown
- 1973-06-28 SE SE7309141A patent/SE403963B/en unknown
- 1973-06-29 CA CA175,292A patent/CA1001554A/en not_active Expired
- 1973-06-29 CH CH947673A patent/CH595100A5/xx not_active IP Right Cessation
- 1973-06-29 GB GB3107373A patent/GB1432487A/en not_active Expired
- 1973-06-29 AT AT575373A patent/AT333969B/en not_active IP Right Cessation
- 1973-06-29 FR FR7324040A patent/FR2190459B1/fr not_active Expired
- 1973-06-29 NL NL7309090A patent/NL7309090A/xx not_active Application Discontinuation
- 1973-06-30 JP JP48074329A patent/JPS4966838A/ja active Pending
- 1973-06-30 ES ES416478A patent/ES416478A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE37842L (en) | 1973-12-30 |
| ATA575373A (en) | 1976-04-15 |
| AU474403B2 (en) | 1976-07-22 |
| JPS4966838A (en) | 1974-06-28 |
| CH595100A5 (en) | 1978-01-31 |
| GB1432487A (en) | 1976-04-14 |
| DK135789C (en) | 1977-11-28 |
| DE2332383A1 (en) | 1974-01-10 |
| CA1001554A (en) | 1976-12-14 |
| IE37842B1 (en) | 1977-10-26 |
| DK135789B (en) | 1977-06-27 |
| FR2190459B1 (en) | 1977-04-15 |
| NL7309090A (en) | 1974-01-02 |
| AU5745173A (en) | 1975-01-09 |
| FR2190459A1 (en) | 1974-02-01 |
| AT333969B (en) | 1976-12-27 |
| SE403963B (en) | 1978-09-18 |
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