ES420634A1 - Preparation of 2,5-disubstituted benzamides - Google Patents
Preparation of 2,5-disubstituted benzamidesInfo
- Publication number
- ES420634A1 ES420634A1 ES420634A ES420634A ES420634A1 ES 420634 A1 ES420634 A1 ES 420634A1 ES 420634 A ES420634 A ES 420634A ES 420634 A ES420634 A ES 420634A ES 420634 A1 ES420634 A1 ES 420634A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- formula
- radical
- alkoxy
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
Preparation procedure for benzamides of general formula: **(See formula)** as well as its pharmaceutically acceptable mineral or organic acid addition salts; their quaternary ammonium salts obtained by reacting these benzamides with an aliphatic or aromatic alcoholic agent, formula in which A is a radical containing at least two amine functions, one of which is capable of binding to the acyl function, another being minus tertiary, Z is an alcohol or alkenyl radical of 1 to 5 carbon atoms, X is an alcohol, amino, aminoalcohyl radical; characterized in that an aminated compound of general formula AH2 (I) (having the meaning mentioned above) is reacted with a halogenated phosphite of general formula (II): **(See formula)** in which R1 is an alkoxy, phenyloxy group; R2 is a halogen; R3 can be either a halogen, or a hydroxy, alkoxy, or phenyloxy group, in this case R1 and R3 can be linked to form an alcoholylenedioxy or o-phenylenedioxy group; and why the phosphorous compound of general formulas (III) and (IV) thus obtained, treated with a benzoic acid substituted in positions 2 and 5 (V) leads to the desired benzamide; in the general formula (III): **(See formula)** A and R1 have the aforementioned meanings, R4 is either an alkoxy or phenyloxy group, or it may be attached to R1 to form an alcohol or ethylenedioxy group, or it can be the aminated radical AH; in the general formula (IV): R1 - P = A (IV) R1 and A have the aforementioned meanings; in the general formula (V): **(See formula)** Z and X have the aforementioned meanings. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7241583A FR2206937B1 (en) | 1972-11-22 | 1972-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES420634A1 true ES420634A1 (en) | 1976-04-16 |
Family
ID=9107559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES420634A Expired ES420634A1 (en) | 1972-11-22 | 1973-11-17 | Preparation of 2,5-disubstituted benzamides |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS5218185B2 (en) |
AR (1) | AR207320A1 (en) |
AT (1) | AT331219B (en) |
CA (1) | CA991192A (en) |
DE (1) | DE2357595A1 (en) |
ES (1) | ES420634A1 (en) |
FI (1) | FI57930C (en) |
FR (1) | FR2206937B1 (en) |
GB (1) | GB1415106A (en) |
IE (1) | IE38598B1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2305176A1 (en) * | 1975-03-28 | 1976-10-22 | Ile De France | NEW DRUG BASED ON N- (DIETHYLAMINOETHYL) 2-METHOXY-5-METHYL-SULFONYL BENZAMIDE |
JPS5371709U (en) * | 1976-11-19 | 1978-06-15 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR72F (en) * | 1963-10-15 | |||
US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
BE791677A (en) * | 1972-07-19 | 1973-03-16 | Renfag Sa | PROCESS FOR THE PREPARATION OF N- (DIETHYLAMINOETHYL) -2- METHOXY-5-METHYLSULFONYL-BENZAMIDE |
-
1972
- 1972-11-22 FR FR7241583A patent/FR2206937B1/fr not_active Expired
-
1973
- 1973-01-01 AR AR25105473A patent/AR207320A1/en active
- 1973-11-15 GB GB5313073A patent/GB1415106A/en not_active Expired
- 1973-11-16 IE IE207773A patent/IE38598B1/en unknown
- 1973-11-16 FI FI355373A patent/FI57930C/en active
- 1973-11-17 ES ES420634A patent/ES420634A1/en not_active Expired
- 1973-11-19 DE DE19732357595 patent/DE2357595A1/en not_active Withdrawn
- 1973-11-19 AT AT967873A patent/AT331219B/en not_active IP Right Cessation
- 1973-11-20 JP JP13117173A patent/JPS5218185B2/ja not_active Expired
- 1973-11-21 CA CA186,406A patent/CA991192A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI57930B (en) | 1980-07-31 |
IE38598B1 (en) | 1978-04-26 |
AT331219B (en) | 1976-08-10 |
JPS504042A (en) | 1975-01-16 |
GB1415106A (en) | 1975-11-26 |
JPS5218185B2 (en) | 1977-05-20 |
FR2206937A1 (en) | 1974-06-14 |
FI57930C (en) | 1980-11-10 |
IE38598L (en) | 1974-05-22 |
ATA967873A (en) | 1975-11-15 |
AR207320A1 (en) | 1976-09-30 |
DE2357595A1 (en) | 1974-05-30 |
CA991192A (en) | 1976-06-15 |
FR2206937B1 (en) | 1977-01-14 |
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