ES420634A1 - Preparation of 2,5-disubstituted benzamides - Google Patents

Preparation of 2,5-disubstituted benzamides

Info

Publication number
ES420634A1
ES420634A1 ES420634A ES420634A ES420634A1 ES 420634 A1 ES420634 A1 ES 420634A1 ES 420634 A ES420634 A ES 420634A ES 420634 A ES420634 A ES 420634A ES 420634 A1 ES420634 A1 ES 420634A1
Authority
ES
Spain
Prior art keywords
general formula
formula
radical
alkoxy
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES420634A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SICIETE D ETUDES SCIENT ET IND
Original Assignee
SICIETE D ETUDES SCIENT ET IND
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SICIETE D ETUDES SCIENT ET IND filed Critical SICIETE D ETUDES SCIENT ET IND
Publication of ES420634A1 publication Critical patent/ES420634A1/en
Expired legal-status Critical Current

Links

Abstract

Preparation procedure for benzamides of general formula: **(See formula)** as well as its pharmaceutically acceptable mineral or organic acid addition salts; their quaternary ammonium salts obtained by reacting these benzamides with an aliphatic or aromatic alcoholic agent, formula in which A is a radical containing at least two amine functions, one of which is capable of binding to the acyl function, another being minus tertiary, Z is an alcohol or alkenyl radical of 1 to 5 carbon atoms, X is an alcohol, amino, aminoalcohyl radical; characterized in that an aminated compound of general formula AH2 (I) (having the meaning mentioned above) is reacted with a halogenated phosphite of general formula (II): **(See formula)** in which R1 is an alkoxy, phenyloxy group; R2 is a halogen; R3 can be either a halogen, or a hydroxy, alkoxy, or phenyloxy group, in this case R1 and R3 can be linked to form an alcoholylenedioxy or o-phenylenedioxy group; and why the phosphorous compound of general formulas (III) and (IV) thus obtained, treated with a benzoic acid substituted in positions 2 and 5 (V) leads to the desired benzamide; in the general formula (III): **(See formula)** A and R1 have the aforementioned meanings, R4 is either an alkoxy or phenyloxy group, or it may be attached to R1 to form an alcohol or ethylenedioxy group, or it can be the aminated radical AH; in the general formula (IV): R1 - P = A (IV) R1 and A have the aforementioned meanings; in the general formula (V): **(See formula)** Z and X have the aforementioned meanings. (Machine-translation by Google Translate, not legally binding)
ES420634A 1972-11-22 1973-11-17 Preparation of 2,5-disubstituted benzamides Expired ES420634A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7241583A FR2206937B1 (en) 1972-11-22 1972-11-22

Publications (1)

Publication Number Publication Date
ES420634A1 true ES420634A1 (en) 1976-04-16

Family

ID=9107559

Family Applications (1)

Application Number Title Priority Date Filing Date
ES420634A Expired ES420634A1 (en) 1972-11-22 1973-11-17 Preparation of 2,5-disubstituted benzamides

Country Status (10)

Country Link
JP (1) JPS5218185B2 (en)
AR (1) AR207320A1 (en)
AT (1) AT331219B (en)
CA (1) CA991192A (en)
DE (1) DE2357595A1 (en)
ES (1) ES420634A1 (en)
FI (1) FI57930C (en)
FR (1) FR2206937B1 (en)
GB (1) GB1415106A (en)
IE (1) IE38598B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2305176A1 (en) * 1975-03-28 1976-10-22 Ile De France NEW DRUG BASED ON N- (DIETHYLAMINOETHYL) 2-METHOXY-5-METHYL-SULFONYL BENZAMIDE
JPS5371709U (en) * 1976-11-19 1978-06-15

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR72F (en) * 1963-10-15
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
BE791677A (en) * 1972-07-19 1973-03-16 Renfag Sa PROCESS FOR THE PREPARATION OF N- (DIETHYLAMINOETHYL) -2- METHOXY-5-METHYLSULFONYL-BENZAMIDE

Also Published As

Publication number Publication date
FI57930B (en) 1980-07-31
IE38598B1 (en) 1978-04-26
AT331219B (en) 1976-08-10
JPS504042A (en) 1975-01-16
GB1415106A (en) 1975-11-26
JPS5218185B2 (en) 1977-05-20
FR2206937A1 (en) 1974-06-14
FI57930C (en) 1980-11-10
IE38598L (en) 1974-05-22
ATA967873A (en) 1975-11-15
AR207320A1 (en) 1976-09-30
DE2357595A1 (en) 1974-05-30
CA991192A (en) 1976-06-15
FR2206937B1 (en) 1977-01-14

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