GB1415106A - Preparation of 2,5-disubstituted benzamides - Google Patents

Preparation of 2,5-disubstituted benzamides

Info

Publication number
GB1415106A
GB1415106A GB5313073A GB5313073A GB1415106A GB 1415106 A GB1415106 A GB 1415106A GB 5313073 A GB5313073 A GB 5313073A GB 5313073 A GB5313073 A GB 5313073A GB 1415106 A GB1415106 A GB 1415106A
Authority
GB
United Kingdom
Prior art keywords
general formula
defined above
benzamide
radical
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5313073A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Publication of GB1415106A publication Critical patent/GB1415106A/en
Expired legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

1415106 Benzamide production SOC D'- ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE 15 Nov 1973 [22 Nov 1972] 53130/73 Heading C2C The invention comprises a method of preparing a therapeutic benzamide of the general formula in which A is a radical with at least two amine functions, one of which is capable of being bonded to the acyl function and at least one other of which is tertiary, Z is a C 1-5 alkyl or C 2-5 alkenyl radical and X is an alkyl, amino or aminoalkyl radical, that comprises reacting an amino compound of the general formula where A is as defined above with a halogen phosphite of general formula where R 1 is an alkoxy or phenyloxy group, R 2 is a halogen atom and R 3 is a halogen atom or hydroxy, alkoxy or phenyloxy group, or R 1 and R 3 are bonded to form an alkylenedioxy or o-phenylenedioxy group, to produce a phosphorus compound of general formula or R 1 P=A, in which A and R 1 are as defined above and R 4 is an alkoxy or phenyloxy group, or is bonded with R 1 to form an alkylenedioxy or o-phenylenedioxy group, or is an amino radical of formula where A is as defined above; and heating the phosphorus compound with a benzoic acid compound of general formula in which Z and X are as defined above to produce the desired benzamide. The examples describe the preparation of N - (diethylaminoethyl) - 2 - methoxy - 5 - methylsulphonyl - benzamide and N - (1 - ethyl - 2- pyrrolidylmethyl) - 2 - methoxy - 5 - ethylsulphonyl and -5-sulphamoyl-bemamides.
GB5313073A 1972-11-22 1973-11-15 Preparation of 2,5-disubstituted benzamides Expired GB1415106A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7241583A FR2206937B1 (en) 1972-11-22 1972-11-22

Publications (1)

Publication Number Publication Date
GB1415106A true GB1415106A (en) 1975-11-26

Family

ID=9107559

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5313073A Expired GB1415106A (en) 1972-11-22 1973-11-15 Preparation of 2,5-disubstituted benzamides

Country Status (10)

Country Link
JP (1) JPS5218185B2 (en)
AR (1) AR207320A1 (en)
AT (1) AT331219B (en)
CA (1) CA991192A (en)
DE (1) DE2357595A1 (en)
ES (1) ES420634A1 (en)
FI (1) FI57930C (en)
FR (1) FR2206937B1 (en)
GB (1) GB1415106A (en)
IE (1) IE38598B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2305176A1 (en) * 1975-03-28 1976-10-22 Ile De France NEW DRUG BASED ON N- (DIETHYLAMINOETHYL) 2-METHOXY-5-METHYL-SULFONYL BENZAMIDE
JPS5371709U (en) * 1976-11-19 1978-06-15

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR72F (en) * 1963-10-15
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
BE791677A (en) * 1972-07-19 1973-03-16 Renfag Sa PROCESS FOR THE PREPARATION OF N- (DIETHYLAMINOETHYL) -2- METHOXY-5-METHYLSULFONYL-BENZAMIDE

Also Published As

Publication number Publication date
AR207320A1 (en) 1976-09-30
IE38598B1 (en) 1978-04-26
JPS5218185B2 (en) 1977-05-20
ES420634A1 (en) 1976-04-16
FR2206937B1 (en) 1977-01-14
CA991192A (en) 1976-06-15
FI57930B (en) 1980-07-31
JPS504042A (en) 1975-01-16
FR2206937A1 (en) 1974-06-14
DE2357595A1 (en) 1974-05-30
FI57930C (en) 1980-11-10
ATA967873A (en) 1975-11-15
IE38598L (en) 1974-05-22
AT331219B (en) 1976-08-10

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19921115