ES415611A1 - N-substituted prostaglandin carboxamides - Google Patents

N-substituted prostaglandin carboxamides

Info

Publication number
ES415611A1
ES415611A1 ES415611A ES415611A ES415611A1 ES 415611 A1 ES415611 A1 ES 415611A1 ES 415611 A ES415611 A ES 415611A ES 415611 A ES415611 A ES 415611A ES 415611 A1 ES415611 A1 ES 415611A1
Authority
ES
Spain
Prior art keywords
carbon atoms
see formula
substituted
arioyl
tetrahydropyranyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES415611A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES415611A1 publication Critical patent/ES415611A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Abstract

A procedure to prepare a prostaglandin of the structure: ** (See formula) ** wherein: R is an alkanoyl having from 2 to 8 carbon atoms or a cycloalkanoyl having from 4 to 8 carbon atoms; arioyl or a substituted arioyl having 7 to 22 carbon atoms in which the substituent is methyl, halogen, or rnethoxy; an alkylsulfonyl having 1 to 7 carbon atoms; heteroarylsulfonyl, arylsulfonyl, or substituted arylsulfonyl in which the substituent is methyl, halogen, or methoxy; R1 is hydrogen or an alkyl having 1 to 3 carbon atoms; it is an alkyl having 5 to 11 carbon atoms; R3 and R4 are hydrogen or tetrahydropyranyl; W is a single tie or a double cis tie; Z is a single ligation or a double trans ligation; M is keto, ** (See formula) ** and its C9, C11, and C15 esters wherein said ester group is formyl, alkanoyl having 2 to 5 carbon atoms, or benzoyl; characterized by the fact that a compound of the formula is reacted with aqueous acetic acid: ** (See formula) ** where THP is tetrahydropyranyl, and where R, R1, R2, M, W and Z are as defined above; and, when required, any of the hydroxyl groups of C9, C11 and C15 is esterified by treating the resulting product with the appropriate acylating agents. (Machine-translation by Google Translate, not legally binding)
ES415611A 1972-06-07 1973-06-06 N-substituted prostaglandin carboxamides Expired ES415611A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26051872A 1972-06-07 1972-06-07

Publications (1)

Publication Number Publication Date
ES415611A1 true ES415611A1 (en) 1976-07-16

Family

ID=22989486

Family Applications (3)

Application Number Title Priority Date Filing Date
ES415611A Expired ES415611A1 (en) 1972-06-07 1973-06-06 N-substituted prostaglandin carboxamides
ES430416A Expired ES430416A1 (en) 1972-06-07 1974-09-26 N-substituted prostaglandin carboxamides
ES430417A Expired ES430417A1 (en) 1972-06-07 1974-09-26 N-substituted prostaglandin carboxamides

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES430416A Expired ES430416A1 (en) 1972-06-07 1974-09-26 N-substituted prostaglandin carboxamides
ES430417A Expired ES430417A1 (en) 1972-06-07 1974-09-26 N-substituted prostaglandin carboxamides

Country Status (24)

Country Link
JP (2) JPS5715591B2 (en)
AR (1) AR207434A1 (en)
AT (1) AT340069B (en)
BE (1) BE800580A (en)
CA (1) CA985280A (en)
CH (3) CH591511A5 (en)
CS (1) CS200166B2 (en)
DD (2) DD115687A5 (en)
DE (1) DE2329092A1 (en)
ES (3) ES415611A1 (en)
FI (1) FI58327C (en)
FR (2) FR2187344B1 (en)
GB (2) GB1439511A (en)
HU (3) HU170200B (en)
IE (1) IE38058B1 (en)
IL (2) IL42385A (en)
IN (1) IN138966B (en)
LU (1) LU67754A1 (en)
NL (2) NL160814C (en)
NO (2) NO146538C (en)
PH (2) PH14204A (en)
SE (3) SE415883B (en)
YU (1) YU36498B (en)
ZA (1) ZA733763B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3291E (en) * 1975-04-23 1980-08-22 Upjohn Co PROCEDURE FOR PREPARING ANALOGS OF PROSTAGLANDINAS
US6395787B1 (en) * 2000-02-08 2002-05-28 Allergan Sales, Inc. Ocular hypotensive lipids
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3187043A (en) * 1962-05-18 1965-06-01 Monsanto Co Monohalophosphonium halides

Also Published As

Publication number Publication date
IL42385A0 (en) 1973-07-30
CS200166B2 (en) 1980-08-29
NO146538C (en) 1982-10-20
CH593929A5 (en) 1977-12-30
FR2273814B1 (en) 1977-07-08
HU170487B (en) 1977-06-28
LU67754A1 (en) 1973-12-14
NO142784C (en) 1980-10-15
NO740850L (en) 1973-12-10
FR2187344A1 (en) 1974-01-18
ES430416A1 (en) 1976-10-16
JPS5731692A (en) 1982-02-20
DD109211A5 (en) 1974-10-20
ES430417A1 (en) 1977-03-01
IE38058B1 (en) 1977-12-21
NO142784B (en) 1980-07-07
HU170491B (en) 1977-06-28
FR2273814A1 (en) 1976-01-02
IL51525A0 (en) 1977-04-29
HU170200B (en) 1977-04-28
JPS4954350A (en) 1974-05-27
FI58327C (en) 1981-01-12
ATA504873A (en) 1977-03-15
SE415883B (en) 1980-11-10
BE800580A (en) 1973-12-07
IE38058L (en) 1973-12-07
GB1439511A (en) 1976-06-16
NO146538B (en) 1982-07-12
PH13092A (en) 1979-11-27
AU5643173A (en) 1974-12-05
GB1439512A (en) 1976-06-16
YU152673A (en) 1982-02-25
NL160814C (en) 1979-12-17
FI58327B (en) 1980-09-30
FR2187344B1 (en) 1977-10-28
IL42385A (en) 1979-10-31
PH14204A (en) 1981-04-01
SE418744B (en) 1981-06-22
NL7812163A (en) 1979-04-27
CA985280A (en) 1976-03-09
IN138966B (en) 1976-04-17
ZA733763B (en) 1974-04-24
SE7608224L (en) 1976-07-19
CH605887A5 (en) 1978-10-13
JPS5715591B2 (en) 1982-03-31
AR207434A1 (en) 1976-10-08
NL7307867A (en) 1973-12-11
SE7608225L (en) 1976-07-19
DD115687A5 (en) 1975-10-12
YU36498B (en) 1984-02-29
DE2329092A1 (en) 1974-01-03
AT340069B (en) 1977-11-25
NL160814B (en) 1979-07-16
CH591511A5 (en) 1977-09-30

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