SE7608225L - PROCEDURE FOR PRODUCTION OF PROSTAGLANDINS - Google Patents

PROCEDURE FOR PRODUCTION OF PROSTAGLANDINS

Info

Publication number
SE7608225L
SE7608225L SE7608225A SE7608225A SE7608225L SE 7608225 L SE7608225 L SE 7608225L SE 7608225 A SE7608225 A SE 7608225A SE 7608225 A SE7608225 A SE 7608225A SE 7608225 L SE7608225 L SE 7608225L
Authority
SE
Sweden
Prior art keywords
formula
methoxy
halogen
methyl
prepared
Prior art date
Application number
SE7608225A
Other languages
Swedish (sv)
Inventor
T K Schaaf
L J Czuba
H-J E Hess
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7608225L publication Critical patent/SE7608225L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Abstract

1439512 Phosphonium salts PFIZER Inc 29 May 1973 [7 June 1972] 42096/75 Divided out of 1439511 Headings C2P and C2C Novel phosphonium salts of the formula wherein R is C 2-8 alkanoyl, C 3-8 cycloalkanoyl, aroyl optionally substituted by methyl, methoxy or halogen, C 1-7 alkylsulphonyl, heteroarylsulphonyl, or arylsulphonyl optionally substituted by methyl, methoxy or halogen, are prepared by reacting triphenylphosphine with compounds of the formula which are prepared by acylating 5-bromovaleramide or by reacting compounds of the formula with 5-bromovaleric acid chloride.
SE7608225A 1972-06-07 1976-07-19 PROCEDURE FOR PRODUCTION OF PROSTAGLANDINS SE7608225L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26051872A 1972-06-07 1972-06-07

Publications (1)

Publication Number Publication Date
SE7608225L true SE7608225L (en) 1976-07-19

Family

ID=22989486

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7307522A SE415883B (en) 1972-06-07 1973-05-28 PROCEDURE FOR THE PREPARATION OF N-SUBSTITUTED PROSTAGLANDIN CARBOXAMIDES
SE7608224A SE418744B (en) 1972-06-07 1976-07-19 ASSOCIATIONS FOR USE AS INTERMEDIATES IN THE PRODUCTION OF PROSTAGLANDINES
SE7608225A SE7608225L (en) 1972-06-07 1976-07-19 PROCEDURE FOR PRODUCTION OF PROSTAGLANDINS

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SE7307522A SE415883B (en) 1972-06-07 1973-05-28 PROCEDURE FOR THE PREPARATION OF N-SUBSTITUTED PROSTAGLANDIN CARBOXAMIDES
SE7608224A SE418744B (en) 1972-06-07 1976-07-19 ASSOCIATIONS FOR USE AS INTERMEDIATES IN THE PRODUCTION OF PROSTAGLANDINES

Country Status (24)

Country Link
JP (2) JPS5715591B2 (en)
AR (1) AR207434A1 (en)
AT (1) AT340069B (en)
BE (1) BE800580A (en)
CA (1) CA985280A (en)
CH (3) CH591511A5 (en)
CS (1) CS200166B2 (en)
DD (2) DD115687A5 (en)
DE (1) DE2329092A1 (en)
ES (3) ES415611A1 (en)
FI (1) FI58327C (en)
FR (2) FR2187344B1 (en)
GB (2) GB1439511A (en)
HU (3) HU170200B (en)
IE (1) IE38058B1 (en)
IL (2) IL42385A (en)
IN (1) IN138966B (en)
LU (1) LU67754A1 (en)
NL (2) NL160814C (en)
NO (2) NO146538C (en)
PH (2) PH14204A (en)
SE (3) SE415883B (en)
YU (1) YU36498B (en)
ZA (1) ZA733763B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3291E (en) * 1975-04-23 1980-08-22 Upjohn Co PROCEDURE FOR PREPARING ANALOGS OF PROSTAGLANDINAS
US6395787B1 (en) * 2000-02-08 2002-05-28 Allergan Sales, Inc. Ocular hypotensive lipids
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3187043A (en) * 1962-05-18 1965-06-01 Monsanto Co Monohalophosphonium halides

Also Published As

Publication number Publication date
IL42385A0 (en) 1973-07-30
CS200166B2 (en) 1980-08-29
NO146538C (en) 1982-10-20
CH593929A5 (en) 1977-12-30
FR2273814B1 (en) 1977-07-08
HU170487B (en) 1977-06-28
LU67754A1 (en) 1973-12-14
NO142784C (en) 1980-10-15
NO740850L (en) 1973-12-10
FR2187344A1 (en) 1974-01-18
ES430416A1 (en) 1976-10-16
JPS5731692A (en) 1982-02-20
DD109211A5 (en) 1974-10-20
ES430417A1 (en) 1977-03-01
IE38058B1 (en) 1977-12-21
NO142784B (en) 1980-07-07
HU170491B (en) 1977-06-28
FR2273814A1 (en) 1976-01-02
IL51525A0 (en) 1977-04-29
HU170200B (en) 1977-04-28
JPS4954350A (en) 1974-05-27
FI58327C (en) 1981-01-12
ATA504873A (en) 1977-03-15
SE415883B (en) 1980-11-10
BE800580A (en) 1973-12-07
IE38058L (en) 1973-12-07
GB1439511A (en) 1976-06-16
NO146538B (en) 1982-07-12
PH13092A (en) 1979-11-27
AU5643173A (en) 1974-12-05
GB1439512A (en) 1976-06-16
YU152673A (en) 1982-02-25
NL160814C (en) 1979-12-17
FI58327B (en) 1980-09-30
FR2187344B1 (en) 1977-10-28
IL42385A (en) 1979-10-31
PH14204A (en) 1981-04-01
SE418744B (en) 1981-06-22
NL7812163A (en) 1979-04-27
CA985280A (en) 1976-03-09
IN138966B (en) 1976-04-17
ZA733763B (en) 1974-04-24
SE7608224L (en) 1976-07-19
CH605887A5 (en) 1978-10-13
ES415611A1 (en) 1976-07-16
JPS5715591B2 (en) 1982-03-31
AR207434A1 (en) 1976-10-08
NL7307867A (en) 1973-12-11
DD115687A5 (en) 1975-10-12
YU36498B (en) 1984-02-29
DE2329092A1 (en) 1974-01-03
AT340069B (en) 1977-11-25
NL160814B (en) 1979-07-16
CH591511A5 (en) 1977-09-30

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