ES415034A1 - Procedimiento para preparar derivados de retraciclina dul- ces y acuosolubles. - Google Patents
Procedimiento para preparar derivados de retraciclina dul- ces y acuosolubles.Info
- Publication number
- ES415034A1 ES415034A1 ES415034A ES415034A ES415034A1 ES 415034 A1 ES415034 A1 ES 415034A1 ES 415034 A ES415034 A ES 415034A ES 415034 A ES415034 A ES 415034A ES 415034 A1 ES415034 A1 ES 415034A1
- Authority
- ES
- Spain
- Prior art keywords
- glycyrrhizic acid
- water
- tetracycline antibiotics
- soluble derivatives
- tetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940072172 tetracycline antibiotic Drugs 0.000 title abstract 4
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 abstract 3
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 abstract 3
- 229960004949 glycyrrhizic acid Drugs 0.000 abstract 3
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 abstract 3
- 239000001685 glycyrrhizic acid Substances 0.000 abstract 3
- 235000019410 glycyrrhizin Nutrition 0.000 abstract 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- XIYOPDCBBDCGOE-IWVLMIASSA-N (4s,4ar,5s,5ar,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C=C1C2=CC=CC(O)=C2C(O)=C2[C@@H]1[C@H](O)[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O XIYOPDCBBDCGOE-IWVLMIASSA-N 0.000 abstract 1
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 abstract 1
- MTCQOMXDZUULRV-ADOAZJKMSA-N (4s,4as,5ar,12ar)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=CC=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O MTCQOMXDZUULRV-ADOAZJKMSA-N 0.000 abstract 1
- 229960003722 doxycycline Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229940042016 methacycline Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960004023 minocycline Drugs 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229950000614 sancycline Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25640672A | 1972-05-24 | 1972-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES415034A1 true ES415034A1 (es) | 1976-05-16 |
Family
ID=22972116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES415034A Expired ES415034A1 (es) | 1972-05-24 | 1973-05-23 | Procedimiento para preparar derivados de retraciclina dul- ces y acuosolubles. |
Country Status (13)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5215699A (en) * | 1975-09-29 | 1977-02-05 | Toray Industries | Permanent sweat absorbing finish of polyester synthetic knitt fabric |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| JPS59228084A (ja) * | 1983-06-09 | 1984-12-21 | 日本合成化学工業株式会社 | ウォータージェットルーム用経糸糊剤 |
-
1973
- 1973-05-15 NL NL7306746A patent/NL7306746A/xx unknown
- 1973-05-17 AT AT431773A patent/AT326820B/de not_active IP Right Cessation
- 1973-05-22 HU HUBA2930A patent/HU167706B/hu unknown
- 1973-05-22 SU SU1931671A patent/SU499803A3/ru active
- 1973-05-23 DE DE2326106A patent/DE2326106A1/de active Pending
- 1973-05-23 JP JP48057655A patent/JPS4941519A/ja active Pending
- 1973-05-23 BE BE131418A patent/BE799914A/xx unknown
- 1973-05-23 FR FR7318637A patent/FR2185393A1/fr not_active Withdrawn
- 1973-05-23 ES ES415034A patent/ES415034A1/es not_active Expired
- 1973-05-23 GB GB2468173A patent/GB1403647A/en not_active Expired
- 1973-05-24 ZA ZA733521A patent/ZA733521B/xx unknown
- 1973-05-28 AU AU56219/73A patent/AU5621973A/en not_active Expired
- 1973-05-29 CA CA172,886A patent/CA983023A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE799914A (fr) | 1973-09-17 |
| ATA431773A (de) | 1975-03-15 |
| JPS4941519A (enrdf_load_stackoverflow) | 1974-04-18 |
| FR2185393A1 (enrdf_load_stackoverflow) | 1974-01-04 |
| ZA733521B (en) | 1974-04-24 |
| AT326820B (de) | 1975-12-29 |
| CA983023A (en) | 1976-02-03 |
| DE2326106A1 (de) | 1973-12-06 |
| GB1403647A (en) | 1975-08-28 |
| SU499803A3 (ru) | 1976-01-15 |
| HU167706B (enrdf_load_stackoverflow) | 1975-12-25 |
| NL7306746A (enrdf_load_stackoverflow) | 1973-11-27 |
| AU5621973A (en) | 1974-11-28 |
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