ES411982A1 - Process for the preparation of alpha-6-deoxytetracyclines - Google Patents
Process for the preparation of alpha-6-deoxytetracyclinesInfo
- Publication number
- ES411982A1 ES411982A1 ES411982A ES411982A ES411982A1 ES 411982 A1 ES411982 A1 ES 411982A1 ES 411982 A ES411982 A ES 411982A ES 411982 A ES411982 A ES 411982A ES 411982 A1 ES411982 A1 ES 411982A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- alpha
- preparation
- see formula
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Abstract
Procedure for the preparation of alpha-6-dioxytetracyclines, of general formula II: **(See formula)** where Y = H, F, C1, Br, I, R = H, OH, -O-CO-R', and R'= C1 to C6 alkyl group by homogeneous catalytic hydrogenation of 6-dimethyl-6-dioxy-6-methylenetetracyclines of general formula I: **(See formula)** in which Y and R have the aforementioned meaning, with the use of catalysts soluble in the reaction medium, consisting of noble metal complexes with electron donor linkers of the phosphine, arsine, and tertiary stibnin type; the noble metals used being Rh, Pd, Ru, Os, Ir, Pt, Ni; the suitable linkers being triphenylphosphine, triphenylarsine, triphenylstibine, tributylphoafine, triethylphosphine, diethylphenylphosphine, diphenylethylphosphine; using polar solvents of the type mono- or polyoxyhydrinated alcohols from C1 to C4, N, N'-dimethylformamide, N, N'-dimethylacetamide, dioxane, tetrahydrofuran, methoxyethanol, ethoxyethanol, acetonitrile, pyridine; working at temperatures between 15º and 80ºC, for times of 1 to 8 hours in the presence of hydrogen, at pressures of 1 to 150 kg/cm2. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2095972 | 1972-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES411982A1 true ES411982A1 (en) | 1976-01-01 |
Family
ID=11174633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES411982A Expired ES411982A1 (en) | 1972-02-24 | 1973-02-23 | Process for the preparation of alpha-6-deoxytetracyclines |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS6114145B2 (en) |
| AT (1) | AT320627B (en) |
| AU (1) | AU477038B2 (en) |
| CA (1) | CA1003410A (en) |
| CH (1) | CH579531A5 (en) |
| DE (1) | DE2308227C2 (en) |
| DK (1) | DK153394C (en) |
| ES (1) | ES411982A1 (en) |
| GB (1) | GB1418137A (en) |
| IL (1) | IL41600A (en) |
| NL (1) | NL178591C (en) |
| NO (1) | NO138563C (en) |
| PH (1) | PH10072A (en) |
| SE (1) | SE389862B (en) |
| ZA (1) | ZA731178B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE435619C (en) * | 1973-02-01 | 1985-10-31 | Pfizer | PROCEDURE FOR PREPARING A 6ALFA DEOXYTETRACYCLINE |
| US3954862A (en) * | 1973-04-20 | 1976-05-04 | Pfizer Inc. | Process for producing α-6-deoxytetracyclines |
| PT74303B (en) * | 1982-01-19 | 1983-08-08 | Joao Emerico Villax | PROCESS FOR THE PREPARATION OF NEW CATALYZERS CONTAINING RHODIUM AND USE THEREOF |
| JPH047001Y2 (en) * | 1986-10-15 | 1992-02-25 | ||
| CN111732522B (en) * | 2020-07-21 | 2022-10-18 | 山东国邦药业有限公司 | Preparation method of doxycycline |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1430859A (en) * | 1960-05-23 | 1966-05-25 |
-
1973
- 1973-02-19 GB GB811973A patent/GB1418137A/en not_active Expired
- 1973-02-19 CH CH234973A patent/CH579531A5/xx not_active IP Right Cessation
- 1973-02-20 ZA ZA731178A patent/ZA731178B/en unknown
- 1973-02-20 DE DE2308227A patent/DE2308227C2/en not_active Expired
- 1973-02-20 CA CA164,204A patent/CA1003410A/en not_active Expired
- 1973-02-21 SE SE7302447A patent/SE389862B/en unknown
- 1973-02-21 DK DK093273A patent/DK153394C/en not_active IP Right Cessation
- 1973-02-22 IL IL41600A patent/IL41600A/en unknown
- 1973-02-22 AU AU52502/73A patent/AU477038B2/en not_active Expired
- 1973-02-22 AT AT155773A patent/AT320627B/en not_active IP Right Cessation
- 1973-02-22 PH PH14362*A patent/PH10072A/en unknown
- 1973-02-22 NL NLAANVRAGE7302506,A patent/NL178591C/en not_active IP Right Cessation
- 1973-02-23 ES ES411982A patent/ES411982A1/en not_active Expired
- 1973-02-23 NO NO737/73A patent/NO138563C/en unknown
- 1973-02-24 JP JP48022592A patent/JPS6114145B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK153394B (en) | 1988-07-11 |
| ZA731178B (en) | 1973-11-28 |
| AU477038B2 (en) | 1976-10-14 |
| AU5250273A (en) | 1974-08-22 |
| DK153394C (en) | 1993-08-02 |
| IL41600A0 (en) | 1973-04-30 |
| GB1418137A (en) | 1975-12-17 |
| JPS4897864A (en) | 1973-12-13 |
| NL178591B (en) | 1985-11-18 |
| PH10072A (en) | 1976-08-05 |
| DE2308227A1 (en) | 1973-08-30 |
| IL41600A (en) | 1975-07-28 |
| CH579531A5 (en) | 1976-09-15 |
| DE2308227C2 (en) | 1983-01-13 |
| NO138563C (en) | 1978-09-27 |
| AT320627B (en) | 1975-02-25 |
| CA1003410A (en) | 1977-01-11 |
| JPS6114145B2 (en) | 1986-04-17 |
| NO138563B (en) | 1978-06-19 |
| SE389862B (en) | 1976-11-22 |
| NL178591C (en) | 1992-09-16 |
| NL7302506A (en) | 1973-08-28 |
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